A modified ex vivo skin organ culture system for functional studies

2001 ◽  
Vol 293 (4) ◽  
pp. 184-190 ◽  
Author(s):  
Arjen R. Companjen ◽  
L. I. van der Wel ◽  
Liu Wei ◽  
J. D. Laman ◽  
E. P. Prens
Keyword(s):  
Organ Culture ◽  
Culture System ◽  
Ex Vivo ◽  
Functional Studies ◽  
Organ Culture System ◽  
Skin Organ Culture

Bench-Top Validation Tests for Tissue-Engineered Arteries

2000 ◽  
Author(s):  
Shawn Chin Quee ◽  
Hai-Chao Han ◽  
David N. Ku
Keyword(s):  
Organ Culture ◽  
Culture System ◽  
Comprehensive Evaluation ◽  
Ex Vivo ◽  
Vascular Grafts ◽  
Living System ◽  
Organ Culture System ◽  
Flow Pressure ◽  
Validation Tests

Abstract Standard tests are needed for evaluating and comparing the mechanical and biological functions of tissue engineered arteries and other vascular grafts. We propose an ex vivo organ culture system as a living system for testing tissue-engineered vascular grafts. This bench-top organ culture system mimics the physiological environment of arteries including the flow, pressure, and the axial stretch. Arterial mechanical properties and physiologic functions including compliance, burst pressure, and contractile functions can be assessed before an expensive long-term animal test is initiated. Test results of natural arteries indicate that organ culture is a valid model for comprehensive evaluation of tissue-engineered vascular grafts.

Axial Stretch Increases Cell Proliferation in Arteries in Organ Culture

2000 ◽  
Author(s):  
Hai-Chao Han ◽  
Raymond P. Vito ◽  
Kristin Michael ◽  
David N. Ku
Keyword(s):  
Cell Proliferation ◽  
Smooth Muscle ◽  
Organ Culture ◽  
Vascular Function ◽  
Culture System ◽  
Carotid Arteries ◽  
Ex Vivo ◽  
Axial Stretch ◽  
Organ Culture System ◽  
Physiological Flow

Abstract To study the effect of axial stretch on vascular function and wall remodeling, porcine carotid arteries were cultured under conditions of physiological flow and elevated axial stretch in an ex vivo organ culture system. Smooth muscle cell proliferation was measured by bromodeoxyuridine index. Results showed that cell proliferation was significantly increased in the highly stretched arteries when compared to the normally stretched arteries. This may indicate the feasibility of stimulating new arterial growth by stretching natural arteries.

Role of TNF- α in sunburn cell formation in a skin organ culture system

1998 ◽  
Vol 16 ◽  
pp. S230
Author(s):  
Kenta Tsuru ◽  
Fumio Washio ◽  
Koichi Nakagawa ◽  
Tatsuya Horikawa ◽  
Masato Ueda ◽  
...  
Keyword(s):  
Organ Culture ◽  
Culture System ◽  
Cell Formation ◽  
Organ Culture System ◽  
Tnf Α ◽  
Sunburn Cell ◽  
Skin Organ Culture

scholarly journals Invasion of Wolbachia into Anopheles and Other Insect Germlines in an Ex vivo Organ Culture System

PLoS ONE ◽  
2012 ◽  
Vol 7 (4) ◽  
pp. e36277 ◽  
Author(s):  
Grant L. Hughes ◽  
Andrew D. Pike ◽  
Ping Xue ◽  
Jason L. Rasgon
Keyword(s):  
Organ Culture ◽  
Culture System ◽  
Ex Vivo ◽  
Organ Culture System
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