T lymphocytes reactive for group A streptococcal antigens in chronic plaque psoriatic lesions

1999 ◽  
Vol 291 (10) ◽  
pp. 564-566 ◽  
Author(s):  
B. S. Baker ◽  
D. Brown ◽  
W. Porter ◽  
C. Hardman ◽  
J. J. Garioch ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Group A ◽  
Streptococcal Antigens ◽  
Psoriatic Lesions

Group A streptococcal antigen-specific T lymphocytes in guttate psoriatic lesions

1993 ◽  
Vol 128 (5) ◽  
pp. 493-499 ◽  
Author(s):  
B.S. BAKER ◽  
S. BOKTH ◽  
A. POWLES ◽  
J.J. GARIOCH ◽  
H. LEWIS ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Streptococcal Antigen ◽  
Group A ◽  
Psoriatic Lesions

scholarly journals Analysis of factors affected the SARS-CoV-2 viral shedding time of COVID-19 patients in Anhui, China: a retrospective study

2020 ◽  
Author(s):  
You-Hui Tu ◽  
Yuan-Yuan Wei ◽  
Da-Wei Zhang ◽  
Chang-Shan Chen ◽  
Xian-Wei Hu ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Early Stage ◽  
Serum Glucose ◽  
Viral Shedding ◽  
Cd8 T Lymphocytes ◽  
Cd8 T Lymphocyte ◽  
Tnf Α ◽  
Epidemiological Risk ◽  
Group A ◽  
Group B

Abstract Background The epidemic of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has spread worldwide, but the factors that may affect the SARS-CoV-2 viral shedding time in coronavirus disease 2019 (COVID-19) patients were rarely reported. Methods We retrospectively recruited 40 confirmed common COVID-19 patients and classified them into two groups according to the SARS-CoV-2 viral shedding time (group A (less than 10 days) and group B (10 days or more)). The demographic, laboratory parameters and chest computed tomography (CT) features on admission and the 3 rd day after treatment were analyzed respectively. Results Fourteen patients were in group A and 26 patients in group B, the median SARS-CoV-2 viral shedding time of the two groups was 7 and 16 days respectively. Compared to the group A, the comorbidity, epidemiological risk history, serum glucose and CD4/8 on admission were significantly higher in the group B (P<0.05). On the 3 rd day after treatment, the group B got significantly higher IL-6, IL-2R, TNF-α and CD4/8, and lower platelet and CD8 + T lymphocyte counts than group A (P<0.05). Logistic regression analyses revealed that the higher epidemiological risk history, serum glucose and CD4/8 on admission were significantly associated with a longer SARS-CoV-2 viral shedding time (OR=7.5, 11.41, 9.21 respectively, P<0.05), as well as the higher TNF-α and lower CD8 + T lymphocytes on the 3 rd day after treatment (OR=2.36, 0.98 respectively, P<0.05). Conclusions Our study provides the evidence that the prolonged SARS-CoV-2 viral shedding time might be correlated with the patients’ epidemiological risk history, as well as the serum glucose and CD4/8 on admission, TNF-α and CD8 + T lymphocytes on the 3 rd day after treatment. Our result may help clinicians to distinguish the patients with a prolonged viral shedding time at the early stage.

scholarly journals Streptococcal-induced cell-mediated-immune destruction of cardiac myofibers in vitro.

1977 ◽  
Vol 146 (2) ◽  
pp. 344-360 ◽  
Author(s):  
L C Yang ◽  
P R Soprey ◽  
M K Wittner ◽  
E N Fox
Keyword(s):  
Antigenic Determinants ◽  
Target Cells ◽  
Heart Cells ◽  
Guinea Pig Heart ◽  
Whole Cells ◽  
Group A ◽  
Streptococcal Antigens ◽  
Lymphocyte Cytotoxicity

We have demonstrated that T lymphocytes from the spleens of adult guinea pigs sensitized to group A streptococcal antigens are cytotoxic for cultured fetal guinea pig heart cells. Lymphocyte cytotoxicity, measured by 51Cr release from target cells, was stimulated by sensitization in vivo with group A whole cells, cell walls, and purified protoplast membranes emulsified with complete Freund's adjuvant (CFA). Sensitization with group C streptococcal antigens in CFA or CFA alone produced lymphocytes with little or no specific cytotoxic activity. Target cells of cultured fetal skeletal muscle, liver, or skin were relatively refractory to effector cell cytotoxicity. The presence of antigenic determinants on the membranes of cultured myofibers, cross-reacting with group A streptococcal cellular antigens, was confirmed by immunofluorescence. These data are discussed in terms of a model for poststreptococcal rheumatic myocarditis in which cell-mediated autoimmune mechanisms may participate.

Streptozyme® test for antibodies to Group A streptococcal antigens

1987 ◽  
Vol 6 (1) ◽  
pp. 36-40 ◽  
Author(s):  
MICHAEL A. GERBER ◽  
LAURA L. WRIGHT ◽  
MARTIN F. RANDOLPH
Keyword(s):  
Group A ◽  
Streptococcal Antigens

Sensitization of Epidermal Growth Factor Receptor (EGFR) Inhibitors Induced by Radiotherapy Combined with Programmed Death Ligand-1 (PD-L1) Inhibitors

2022 ◽  
Vol 12 (1) ◽  
pp. 90-96
Author(s):  
Hui Cao ◽  
Wen Xu ◽  
Xianshu Shao ◽  
Zhihong Zhang
Keyword(s):  
Lung Cancer ◽  
T Cells ◽  
Epidermal Growth Factor Receptor ◽  
T Lymphocytes ◽  
Growth Factor Receptor ◽  
X Rays ◽  
Programmed Death Ligand 1 ◽  
Programmed Death ◽  
Group A ◽  
Epidermal Growth

To explore the effect of radiotherapy combined with programmed death ligand-1 (PD-L1) inhibitors on the sensitization of epidermal growth factor receptor (EGFR) inhibitors, 76 patients with nonsmall cell lung cancer (NSCLC) were rolled into group A (lung adenocarcinoma, 55 cases) and group B (lung squamous carcinoma, 21 cases). Another 63 healthy volunteers were set as controls (group C). Patients in group A were rolled into mutation group (15 cases) and wild group (22 cases) regarding the presence of EGFR mutations. The sPD-L1 protein in serum samples was determined via enzyme-linked immunosorbent assay (ELISA). Expressions of PD-L1, EGFR, and immune interferon (IFN-γ) in lung cancer cell lines (LCCL) mutant PC9 and HCC827, and wild-type A549 and H1299 were analyzed. After separation of T lymphocytes, four LCCLs and T lymphocytes were co-cultured to detect the proliferation and apoptosis of T lymphocytes. The results showed that PD-L1 level in EGFR-sensitive mutant LCCLs PC9 and HCC827 after X-ray irradiation was obviously inferior to controls (P < 0.05). The proliferation of T cells in mutant LCCLs PC9 and HCC827 was substantially superior to co-culture system (co-CS) (P < 0.05). After the PC9 co-CS was treated with X-rays, PD-L1 inhibitors, and X-rays combined with PD-L1 inhibitors, the secretion of IFN-γ was markedly increased versus controls (P < 0.05). In short, radiotherapy combined with PD-L1 inhibitors can enhance the proliferation of T cells and inhibit their apoptosis, and greatly increase the secretion of IFN-γ by T cells.

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