Experimental rabies virus infection of p75 neurotrophin receptor-deficient mice

1999 ◽  
Vol 98 (6) ◽  
pp. 641-644 ◽  
Author(s):  
Alan C. Jackson ◽  
Hannah Park
Keyword(s):  
Virus Infection ◽  
Rabies Virus ◽  
Neurotrophin Receptor ◽  
P75 Neurotrophin Receptor ◽  
Rabies Virus Infection ◽  
Deficient Mice

scholarly journals The Neural Cell Adhesion Molecule Is a Receptor for Rabies Virus

1998 ◽  
Vol 72 (9) ◽  
pp. 7181-7190 ◽  
Author(s):  
Maria-Isabel Thoulouze ◽  
Mireille Lafage ◽  
Melitta Schachner ◽  
Ursula Hartmann ◽  
Harold Cremer ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Virus Infection ◽  
Rabies Virus ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Virus Receptor ◽  
Neural Cell Adhesion ◽  
Rabies Virus Infection ◽  
Deficient Mice

ABSTRACT Previous reports strongly suggest that, in addition to the nicotinic acetylcholine receptor, rabies virus can use other, as-yet-unidentified receptors. We found that laboratory cell lines susceptible to rabies virus infection express the neural cell adhesion molecule (NCAM) (CD56) on their surface, whereas resistant cells do not, supporting the idea that NCAM could be a rabies virus receptor. We observed that (i) incubation with rabies virus decreases the surface expression of NCAM; (ii) treatment of susceptible cells with heparan sulfate, a ligand for NCAM, or with NCAM antibodies significantly reduces the rabies virus infection; and (iii) preincubation of rabies virus inoculum with soluble NCAM protein as a receptor decoy drastically neutralizes the capacity of rabies virus to infect susceptible cells. Moreover, we demonstrated that transfection of resistant L fibroblasts with the NCAM-encoding gene induces rabies virus susceptibility whereas absence of NCAM in the primary cortical cell cultures prepared from NCAM-deficient mice reduces the rabies virus infection and virus production. This provides evidence that NCAM is an in vitro receptor for the rabies virus. Moreover, the in vivo relevance for the use of NCAM as a receptor was demonstrated by the infection of NCAM-deficient mice, in which rabies mortality was delayed and brain invasion by rabies virus was drastically restricted. Our results showed that NCAM, which is expressed mainly in the adult nervous system, plays an important role in rabies infection. However, it cannot be excluded that receptors other than NCAM are utilized. Thus, the description of NCAM as a new rabies virus receptor would be another example of the use by viruses of more than one receptor to gain entry into the host.

Rabies virus infection in a 21-year-old male presenting with ascending paralysis after a bat scratch

2020 ◽  
Vol 5 (3) ◽  
pp. 201-208
Author(s):  
Shay-Anne Daniels ◽  
Elizabeth M King ◽  
Christopher J Olivier ◽  
John PD Harding ◽  
Christine Fehlner-Gardiner ◽  
...  
Keyword(s):  
Virus Infection ◽  
Rabies Virus ◽  
Rabies Virus Infection

Search for antiviral drugs against rabies virus infection

1985 ◽  
Vol 3 ◽  
pp. 86
Author(s):  
F. Bussereau ◽  
M. Picard ◽  
O. Gosselin ◽  
J. Blancou ◽  
J.C. Chermann ◽  
...  
Keyword(s):  
Virus Infection ◽  
Rabies Virus ◽  
Antiviral Drugs ◽  
Rabies Virus Infection

The role of the skin in rabies infection

1926 ◽  
Vol 22 (10) ◽  
pp. 1179-1179
Author(s):  
K. Khalyapin
Keyword(s):  
Virus Infection ◽  
Guinea Pig ◽  
Rabies Virus ◽  
Anatomical Features ◽  
Pig Skin ◽  
Highly Sensitive ◽  
Rabies Virus Infection

The author verified by experiment that the guinea pig skin is an organ highly sensitive to the rabies virus - infection with rabies through the skin is very easy, which the author puts in connection with its anatomical features (a rich network of nerves).

Efficacy of heteropolyanions against rabies virus infection in mice

1986 ◽  
Vol 137 ◽  
pp. 391-400 ◽  
Author(s):  
F. Bussereau ◽  
M. Picard ◽  
C. Malick ◽  
A. Tézé ◽  
J. Blancou
Keyword(s):  
Virus Infection ◽  
Rabies Virus ◽  
Rabies Virus Infection

scholarly journals Chronic Rabies Virus Infection of Cell Cultures

1972 ◽  
Vol 6 (6) ◽  
pp. 988-995 ◽  
Author(s):  
T. J. Wiktor ◽  
H F. Clark
Keyword(s):  
Virus Infection ◽  
Rabies Virus ◽  
Cell Cultures ◽  
Rabies Virus Infection
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