Genotyping of the prion protein gene at codon 129

1999 ◽  
Vol 97 (4) ◽  
pp. 355-358 ◽  
Author(s):  
Klaus Zimmermann ◽  
Peter L. Turecek ◽  
Hans Peter Schwarz
Keyword(s):  
Prion Protein ◽  
Protein Gene ◽  
Prion Protein Gene ◽  
Codon 129

scholarly journals Genetic Polymorphism at Codon 129 of the Prion Protein Gene Is Not Associated With Multiple Sclerosis

2009 ◽  
Vol 66 (2) ◽  
Author(s):  
Olaf Stüve ◽  
Carsten Korth ◽  
Pablo Gabatto ◽  
Elizabeth M. Cameron ◽  
Wei Hu ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Genetic Polymorphism ◽  
Prion Protein ◽  
Protein Gene ◽  
Prion Protein Gene ◽  
Codon 129

Absence of Association between Codon 129 and 219 Polymorphisms of the Prion Protein Gene and Vascular Dementia

2007 ◽  
Vol 24 (2) ◽  
pp. 86-90 ◽  
Author(s):  
Byung-Hoon Jeong ◽  
Hae-Ri Na ◽  
Jae-Chun Bae ◽  
Kyung-Hee Lee ◽  
Yun-Jung Lee ◽  
...  
Keyword(s):  
Vascular Dementia ◽  
Prion Protein ◽  
Protein Gene ◽  
Prion Protein Gene ◽  
Codon 129

Absence of association between codon 129/219 polymorphisms of the prion protein gene and Alzheimer's disease in Japan

2003 ◽  
Vol 54 (4) ◽  
pp. 553-554 ◽  
Author(s):  
Takuya Ohkubo ◽  
Yuji Sakasegawa ◽  
Takashi Asada ◽  
Toru Kinoshita ◽  
Yuichi Goto ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Prion Protein ◽  
Protein Gene ◽  
Prion Protein Gene ◽  
Codon 129

scholarly journals Codon 129 polymorphism of prion protein gene in is not a risk factor for Alzheimer's disease

2013 ◽  
Vol 71 (7) ◽  
pp. 423-427 ◽  
Author(s):  
Jerusa Smid ◽  
Michele Christine Landemberger ◽  
Valéria Santoro Bahia ◽  
Vilma Regina Martins ◽  
Ricardo Nitrini
Keyword(s):  
Risk Factor ◽  
Cognitive Performance ◽  
Prion Protein ◽  
Protein Gene ◽  
Apoe Genotype ◽  
Genotype Distribution ◽  
Prion Protein Gene ◽  
Apolipoprotein E Gene ◽  
Jakob Disease ◽  
Codon 129

Interaction of prion protein and amyloid-b oligomers has been demonstrated recently. Homozygosity at prion protein gene (PRNP) codon 129 is associated with higher risk for Creutzfeldt-Jakob disease. This polymorphism has been addressed as a possible risk factor in Alzheimer disease (AD).ObjectiveTo describe the association between codon 129 polymorphisms and AD.MethodsWe investigated the association of codon 129 polymorphism of PRNP in 99 AD patients and 111 controls, and the association between this polymorphism and cognitive performance. Other polymorphisms of PRNP and additive effect of apolipoprotein E gene (ApoE) were evaluated.ResultsCodon 129 genotype distribution in AD 45.5% methionine (MM), 42.2% methionine valine (MV), 12.1% valine (VV); and 39.6% MM, 50.5% MV, 9.9% VV among controls (p>0.05). There were no differences of cognitive performance concerning codon 129. Stratification according to ApoE genotype did not reveal difference between groups.ConclusionCodon 129 polymorphism is not a risk factor for AD in Brazilian patients.

Prion protein gene codon 129 modulates clinical course of neurological Wilson disease

Neuroreport ◽  
2006 ◽  
Vol 17 (5) ◽  
pp. 549-552 ◽  
Author(s):  
Stephanie Grubenbecher ◽  
Olaf St??ve ◽  
Harald Hefter ◽  
Carsten Korth
Keyword(s):  
Prion Protein ◽  
Wilson Disease ◽  
Protein Gene ◽  
Clinical Course ◽  
Prion Protein Gene ◽  
Codon 129

Codon 129 polymorphism of prion protein gene in sporadic Alzheimer’s disease

2008 ◽  
Vol 15 (2) ◽  
pp. 173-178 ◽  
Author(s):  
A. Poleggi ◽  
A. Bizzarro ◽  
A. Acciarri ◽  
P. Antuono ◽  
S. Bagnoli ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Prion Protein ◽  
Protein Gene ◽  
Prion Protein Gene ◽  
Sporadic Alzheimer’S Disease ◽  
Codon 129

scholarly journals Clinical Features of Fatal Familial Insomnia: Phenotypic Variability in Relation to a Polymorphism at Codon 129 of the Prion Protein Gene

2006 ◽  
Vol 8 (3) ◽  
pp. 515-520 ◽  
Author(s):  
Pasquale Montagna ◽  
Pietro Cortelli ◽  
Patrizia Avoni ◽  
Paolo Tinuper ◽  
Giuseppe Plazzi ◽  
...  
Keyword(s):  
Prion Protein ◽  
Clinical Features ◽  
Protein Gene ◽  
Phenotypic Variability ◽  
Fatal Familial Insomnia ◽  
Prion Protein Gene ◽  
Codon 129
Sign in / Sign up

Export Citation Format

Share Document