A stereological study of dorsal root ganglion cells and nerve root fibers from rats exposed to mercury vapor

1998 ◽  
Vol 96 (2) ◽  
pp. 185-190 ◽  
Author(s):  
Jørgen Drasbæk Schiønning ◽  
Jytte Overgaard Larsen ◽  
Rune Eide
Keyword(s):  
Dorsal Root Ganglion ◽  
Nerve Root ◽  
Dorsal Root ◽  
Ganglion Cells ◽  
Mercury Vapor ◽  
Dorsal Root Ganglion Cells

Effect of gold nanoparticle treated dorsal root ganglion cells on peripheral neurite differentiation

2021 ◽  
Vol 74 ◽  
pp. 105175
Author(s):  
Pallavi Madhusudanan ◽  
Chinnu Jerard ◽  
Neeraj Katiyar ◽  
Gayathri Raju ◽  
Sahadev A. Shankarappa
Keyword(s):  
Dorsal Root Ganglion ◽  
Gold Nanoparticle ◽  
Dorsal Root ◽  
Ganglion Cells ◽  
Dorsal Root Ganglion Cells

Gangliosides attenuate vincristine neurotoxicity on dorsal root ganglion cells

1993 ◽  
Vol 16 (1) ◽  
pp. 11-14 ◽  
Author(s):  
Kouji Houi ◽  
Soichiro Mochio ◽  
Takaaki Kobayashi
Keyword(s):  
Dorsal Root Ganglion ◽  
Dorsal Root ◽  
Ganglion Cells ◽  
Dorsal Root Ganglion Cells

Functional changes in dorsal root ganglion cells after chronic nerve constriction in the rat

1995 ◽  
Vol 73 (5) ◽  
pp. 1811-1820 ◽  
Author(s):  
Y. Xie ◽  
J. Zhang ◽  
M. Petersen ◽  
R. H. LaMotte
Keyword(s):  
Dorsal Root Ganglion ◽  
Dorsal Root ◽  
Ganglion Cells ◽  
Threshold Concentration ◽  
Injury Site ◽  
Functional Changes ◽  
C Fibers ◽  
Excitatory Responses ◽  
Dorsal Root Ganglion Cells ◽  
Thermal Stimuli

1. We studied the effects of a chronic nerve constriction on the evoked responses in dorsal root fibers in the rat to norepinephrine and to thermal stimuli applied either to the dorsal root ganglion (DRG) or the site of nerve injury. We recorded a total of 59 C fibers, 15 A delta-fibers, and 46 A beta-fibers from the L5 dorsal root of the rats 11-52 days after a loose ligation of the ipsilateral sciatic nerve. Most fibers were identified by the presence of spontaneous activity (SA) that originated partially at and/or proximal to the injury site. In addition, we recorded 20 C fibers, 1 A delta-fiber, and 28 A beta-fibers from the dorsal roots of normal, uninjured neurons. 2. In nerve-injured rats, the SA of some C fibers was generally increased by cooling and decreased by heating either site. In contrast, the SA of most A beta-fibers was increased by heating either the injury site or the DRG. Cooling the DRG decreased SA in A beta-fibers, whereas cooling the injury site typically had no effect. Excitatory responses were not evoked in any fiber group when the same thermal stimuli were applied to the nerve or DRG tested in normal, uninjured rats. 3. Norepinephrine (< 0.5 mM) applied either to the injury site or the DRG increased the SA of most C fibers and A delta-fibers but only a minority of A beta-fibers in previously injured nerves. The threshold concentration for excitation of the DRG somata of C fibers was 0.01 mM. No effects were found for fibers in uninjured nerves. 4. The effect of norepinephrine was blocked by a pretreatment with yohimbine, an alpha 2-blocker, but not with prazosin, an alpha 1-blocker. 5. Stimulation of the sympathetic trunk (L2-L3) excited most C fibers and a minority of A beta-fibers. In contrast, the SA of a minority of C fibers and A beta-fibers was depressed during sympathetic stimulation. 6. After a chronic nerve constriction the DRG becomes a source of abnormal activity modulated by sympathetically released norepinephrine acting on alpha 2 receptors in DRG somata. This neuropathic activity may contribute to cutaneous pain and hyperalgesia.

scholarly journals Gymnopilin-a substance produced by the hallucinogenic mushroom, Gymnopilus junonius-mobilizes intracellular Ca2+ in dorsal root ganglion cells

2012 ◽  
Vol 33 (2) ◽  
pp. 111-118 ◽  
Author(s):  
Shunsuke Miyazaki ◽  
Naoki Kitamura ◽  
Aiko Nishio ◽  
Saki Tanaka ◽  
Tomohiko Kayano ◽  
...  
Keyword(s):  
Dorsal Root Ganglion ◽  
Dorsal Root ◽  
Ganglion Cells ◽  
Dorsal Root Ganglion Cells
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