Rare occurrence of inactivating p53 gene mutations in primary non-astrocytic tumors of the central nervous system: reappraisal by yeast functional assay

1998 ◽  
Vol 95 (3) ◽  
pp. 291-296 ◽  
Author(s):  
Michimasa Nozaki ◽  
M. Tada ◽  
Ryoji Matsumoto ◽  
Yutaka Sawamura ◽  
Hiroshi Abe ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Gene Mutations ◽  
P53 Gene ◽  
Functional Assay ◽  
Astrocytic Tumors ◽  
Rare Occurrence ◽  
The Central Nervous System ◽  
P53 Gene Mutations

scholarly journals Prenatal Development of the Human Central Nervous System, Normal and Abnormal

2015 ◽  
Vol 9 (1) ◽  
pp. 61-66 ◽  
Author(s):  
Kohei Shiota
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Obstet Gynecol ◽  
Gene Mutations ◽  
Prenatal Development ◽  
Human Central Nervous System ◽  
Long Period ◽  
The Central Nervous System ◽  
Brain And Spinal Cord ◽  
Developing Nervous System

ABSTRACT The organogenesis of the central nervous system (CNS) begins during the third week of development, but its maturation requires a considerably long period of time until after birth. Therefore the developing nervous system is vulnerable to the deleterious effects of environmental factors during the pre- and perinatal periods. In addition, molecular studies have revealed various gene mutations that are responsible for congenital CNS disorders. This chapter provides an overview of the prenatal development of the human brain and spinal cord. How to cite this article Shiota K. Prenatal Development of the Human Central Nervous System, Normal and Abnormal. Donald School J Ultrasound Obstet Gynecol 2015;9(1):61-66.

Rare occurrence of P53 gene mutations in multiple myeloma

1992 ◽  
Vol 81 (3) ◽  
pp. 440-443 ◽  
Author(s):  
Claude Preudhomme ◽  
Thierry Facon ◽  
Marc Zandecki ◽  
Mickael Vanrumbeke ◽  
Jean Luc Laï ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Gene Mutations ◽  
P53 Gene ◽  
Rare Occurrence ◽  
P53 Gene Mutations

scholarly journals Isolated Intramedullary Lumbar Spine Neurocysticercosis: A Rare Occurrence and Review of Literature

2021 ◽  
Vol 07 (04) ◽  
pp. e327-e336
Author(s):  
Anil Dhar ◽  
Sanjeev Dua ◽  
Hershdeep Singh
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Lumbar Spine ◽  
Literature Review ◽  
Parasitic Infection ◽  
Rare Occurrence ◽  
Review Of Literature ◽  
The Third ◽  
The Central Nervous System

AbstractNeurocysticercosis (NCC) is the most common parasitic infection of the central nervous system. Spinal cysticercosis is a rather rare clinical occurrence. Intramedullary (IM) spinal NCC is rarer still. Furthermore, cases of IM-NCC at lumbar levels are few and far between. We present a case of a 35-year-old male patient who was diagnosed to have IM-NCC at L2-3 level and was managed surgically with no recurrence at 2 years of follow-up. A systematic literature review (1992–2020) highlights it to be only the third case reported with exclusive lumbar involvement

Effects of Hyperoxia on Lung Utrastructure

1970 ◽  
Vol 28 ◽  
pp. 26-27
Author(s):  
Gladys Harrison
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Light Microscopy ◽  
Oxygen Effects ◽  
Age Dependent ◽  
The Central Nervous System ◽  
The Subject ◽  
Space Age ◽  
Alveolar Septa ◽  
Extensive Damage

With the advent of the space age and the need to determine the requirements for a space cabin atmosphere, oxygen effects came into increased importance, even though these effects have been the subject of continuous research for many years. In fact, Priestly initiated oxygen research when in 1775 he published his results of isolating oxygen and described the effects of breathing it on himself and two mice, the only creatures to have had the “privilege” of breathing this “pure air”.Early studies had demonstrated the central nervous system effects at pressures above one atmosphere. Light microscopy revealed extensive damage to the lungs at one atmosphere. These changes which included perivascular and peribronchial edema, focal hemorrhage, rupture of the alveolar septa, and widespread edema, resulted in death of the animal in less than one week. The severity of the symptoms differed between species and was age dependent, with young animals being more resistant.

Emigration of neutrophils in the central nervous system

1983 ◽  
Vol 41 ◽  
pp. 788-789
Author(s):  
John L.Beggs ◽  
John D. Waggener ◽  
Wanda Miller ◽  
Jane Watkins
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Osmium Tetroxide ◽  
White Blood Cells ◽  
Arterial Perfusion ◽  
E Coli ◽  
Intracisternal Injection ◽  
The Central Nervous System ◽  
Brain And Spinal Cord ◽  
Interendothelial Junctions

Studies using mesenteric and ear chamber preparations have shown that interendothelial junctions provide the route for neutrophil emigration during inflammation. The term emigration refers to the passage of white blood cells across the endothelium from the vascular lumen. Although the precise pathway of transendo- thelial emigration in the central nervous system (CNS) has not been resolved, the presence of different physiological and morphological (tight junctions) properties of CNS endothelium may dictate alternate emigration pathways.To study neutrophil emigration in the CNS, we induced meningitis in guinea pigs by intracisternal injection of E. coli bacteria.In this model, leptomeningeal inflammation is well developed by 3 hr. After 3 1/2 hr, animals were sacrificed by arterial perfusion with 3% phosphate buffered glutaraldehyde. Tissues from brain and spinal cord were post-fixed in 1% osmium tetroxide, dehydrated in alcohols and propylene oxide, and embedded in Epon. Thin serial sections were cut with diamond knives and examined in a Philips 300 electron microscope.

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