Morphological characterization of the evolving rat spinal cord injury after photochemically induced ischemia

1997 ◽  
Vol 94 (3) ◽  
pp. 232-239 ◽  
Author(s):  
M. von Euler ◽  
Erik Sundström ◽  
Åke Seiger
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Morphological Characterization ◽  
Rat Spinal Cord ◽  
Cord Injury

MRI characterization of diffusion coefficients in a rat spinal cord injury model

1994 ◽  
Vol 31 (5) ◽  
pp. 488-494 ◽  
Author(s):  
John C. Ford ◽  
David B. Hackney ◽  
David C. Alsop ◽  
Hernan Jara ◽  
Peter M. Joseph ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Diffusion Coefficients ◽  
Rat Spinal Cord ◽  
Spinal Cord Injury Model ◽  
Injury Model ◽  
Cord Injury

Morphological Characterization of Photochemical Graded Spinal Cord Injury in the Rat

2003 ◽  
Vol 20 (5) ◽  
pp. 483-499 ◽  
Author(s):  
Enrique Verdú ◽  
Guillermo García-Alías ◽  
Joaquim Forés ◽  
José M. Vela ◽  
Jordi Cuadras ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Morphological Characterization ◽  
Cord Injury

Temporal Profile and Severity Correlation of a Panel of Rat Spinal Cord Injury Protein Biomarkers

2017 ◽  
Vol 55 (3) ◽  
pp. 2174-2184 ◽  
Author(s):  
Zhihui Yang ◽  
Helen M. Bramlett ◽  
Ahmed Moghieb ◽  
Dongnan Yu ◽  
Ping Wang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Rat Spinal Cord ◽  
Protein Biomarkers ◽  
Temporal Profile ◽  
Cord Injury

The effects of methylprednisolone and the ganglioside GM1 on acute spinal cord injury in rats

1994 ◽  
Vol 80 (1) ◽  
pp. 97-111 ◽  
Author(s):  
Shlomo Constantini ◽  
Wise Young
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Body Weight Loss ◽  
Ganglioside Gm1 ◽  
Rat Spinal Cord ◽  
Neuroprotective Effects ◽  
Content Type ◽  
Human Spinal Cord ◽  
Cord Injury ◽  
Fine Print

✓ Recent clinical trials have reported that methylprednisolone sodium succinate (MP) or the monosialic ganglioside GM1 improves neurological recovery in human spinal cord injury. Because GM1 may have additive or synergistic effects when used with MP, the authors compared MP, GM1, and MP+GM1 treatments in a graded rat spinal cord contusion model. Spinal cord injury was caused by dropping a rod weighing 10 gm from a height of 1.25, 2.5, or 5.0 cm onto the rat spinal cord at T-10, which had been exposed via laminectomy. The lesion volumes were quantified from spinal cord Na and K shifts at 24 hours after injury and the results were verified histologically in separate experiments. A single dose of MP (30 mg/kg), given 5 minutes after injury, reduced 24-hour spinal cord lesion volumes by 56% (p = 0.0052), 28% (p = 0.0065), and 13% (p > 0.05) in the three injury-severity groups, respectively, compared to similarly injured control groups treated with vehicle only. Methylprednisolone also prevented injury-induced hyponatremia and increased body weight loss in the spine-injured rats. When used alone, GM1 (10 to 30 mg/kg) had little or no effect on any measured variable compared to vehicle controls; when given concomitantly with MP, GM1 blocked the neuroprotective effects of MP. At a dose of 3 mg/kg, GM1 partially prevented MP-induced reductions in lesion volumes, while 10 to 30 mg/kg of GM1 completely blocked these effects of MP. The effects of MP on injury-induced hyponatremia and body weight loss were also blocked by GM1. Thus, GM1 antagonized both central and peripheral effects of MP in spine-injured rats. Until this interaction is clarified, the authors recommend that MP and GM1 not be used concomitantly to treat acute human spinal cord injury. Because GM1 modulates protein kinase activity, protein kinases inhibit lipocortins, and lipocortins mediate anti-inflammatory effects of glucocorticoids, it is proposed that the neuroprotective effects of MP are partially due to anti-inflammatory effects and that GM1 antagonizes the effects of MP by inhibiting lipocortin. Possible beneficial effects of GM1 reported in central nervous system injury may be related to the effects on neural recovery rather than acute injury processes.

Up-regulation of TRAF2 Suppresses Neuronal Apoptosis after Rat Spinal Cord Injury

2017 ◽  
Vol 49 (5) ◽  
pp. 589-596 ◽  
Author(s):  
Guanhua Xu ◽  
Jinlong Zhang ◽  
Lingling Wang ◽  
Zhiming Cui ◽  
Xu Sun ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neuronal Apoptosis ◽  
Rat Spinal Cord ◽  
Cord Injury
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