Widespread, restricted low-level measles virus infection of brain in a case of subacute sclerosing panencephalitis

1996 ◽  
Vol 91 (2) ◽  
pp. 135-139 ◽  
Author(s):  
S. H. Isaacson ◽  
D. M. Asher ◽  
M. S. Godec ◽  
C. J. Gibbs ◽  
D. C. Gajdusek
Keyword(s):  
Virus Infection ◽  
Measles Virus ◽  
Subacute Sclerosing Panencephalitis ◽  
Low Level

scholarly journals Subacute Sclerosing Panencephalitis

2019 ◽  
Vol 37 (4) ◽  
pp. 205-208
Author(s):  
Gobinda Chandra Banik ◽  
Sakib Aman ◽  
Farhana Sultana ◽  
Syed Mohammad Arif
Keyword(s):  
Cerebrospinal Fluid ◽  
Virus Infection ◽  
Antibody Titer ◽  
Measles Virus ◽  
Subacute Sclerosing Panencephalitis ◽  
Abnormal Behavior ◽  
Short History ◽  
Altered Consciousness ◽  
History Of ◽  
Metachromatic Leucodystrophy

  Subacute sclerosing panencephalitis (SSPE) is chronic progressive encephalitis of childhood and young adoloscent due to persistent measles virus infection. This case illustrates a 14 year old girl presented with short history of intellectual decline, abnormal behavior, myoclonus and altered consciousness with suggestive neuroimaging mimicking metachromatic leucodystrophy. Subsequently she was diagnosed to be a case of Subacute sclerosing panencephalitis (SSPE) on the basis of Electroencephalography (EEG) and Cerebrospinal fluid(CSF) measles antibody titer. J Bangladesh Coll Phys Surg 2019; 37(4): 205-208

scholarly journals Atypical subacute sclerosing panencephalitis: case report

2007 ◽  
Vol 65 (4a) ◽  
pp. 1030-1033 ◽  
Author(s):  
Marcelo Maroco Cruzeiro ◽  
Thiago Cardoso Vale ◽  
Leopoldo Antônio Pires ◽  
Gláucio Mendes Franco
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Case Report ◽  
Virus Infection ◽  
Effective Treatment ◽  
Measles Virus ◽  
Poor Prognosis ◽  
Subacute Sclerosing Panencephalitis ◽  
Inflammatory Disorder ◽  
The Central Nervous System

Subacute sclerosing panencephalitis (SSPE) is a progressive inflammatory disorder of the central nervous system with both poor prognosis and high mortality. The disease has been related to a persistent and aberrant measles virus infection and no effective treatment has been available. We report a case of SSPE with atypical features including seizures at onset and a fulminant course in a 8 years-old boy who had been previously immunized against measles.

scholarly journals Subacute Sclerosing Panencephalitis in a Toddler: Changing Epidemiological Trends

2013 ◽  
Vol 2013 ◽  
pp. 1-4
Author(s):  
Roosy Aulakh ◽  
Abhimanyu Tiwari
Keyword(s):  
Cerebrospinal Fluid ◽  
Virus Infection ◽  
Clinical Features ◽  
Measles Virus ◽  
Subacute Sclerosing Panencephalitis ◽  
Latency Period ◽  
Slow Virus ◽  
History Of ◽  
Antibody Titers ◽  
Epidemiological Trends

Subacute sclerosing panencephalitis (SSPE) is a devastating “slow virus” brain disease resulting from persistent measles virus infection of neurons. The age at presentation is usually 8 to 11 years with onset usually occurring 2–10 years after measles infection. We report a 2-and-half-year-old boy who presented with progressively increasing myoclonic jerks and subtle cognitive decline. He was diagnosed as a case of SSPE based on clinical features, typical electroencephalographic finding, and elevated cerebrospinal fluid/serum measles antibody titers. He had measles 4 months prior to onset of symptoms. This case along with review of recently published reports suggests progressively decreasing latency period between measles infection and onset of symptoms observed in cases with SSPE. Clinical implication would mean investigating for SSPE even in infants or toddlers with compatible clinical features and recent history of measles infection.

Rapid progressive subacute sclerosing panencephalitis after perinatally acquired measles virus infection

The Lancet ◽  
1995 ◽  
Vol 345 (8957) ◽  
pp. 1124 ◽  
Author(s):  
K. Zwiauer ◽  
Elisabeth Forstenpointner ◽  
Therese Popow-Kraupp ◽  
E. Hauser ◽  
K.A. Jellinger
Keyword(s):  
Virus Infection ◽  
Measles Virus ◽  
Subacute Sclerosing Panencephalitis ◽  
Perinatally Acquired

Use of Protein a Conjugated to Peroxidase to Localize Immunoglobulin G in SSPE Ferret Brain

1982 ◽  
Vol 40 ◽  
pp. 350-351
Author(s):  
Hannah R. Brown ◽  
Anthony F. Nostro ◽  
Halldor Thormar
Keyword(s):  
Immunoglobulin G ◽  
Human Disease ◽  
Measles Virus ◽  
Subacute Sclerosing Panencephalitis ◽  
Protein A ◽  
Inflammatory Lesions ◽  
Sspe Virus ◽  
Specific Immunoglobulin ◽  
Antibody Titers ◽  
The Brain

Subacute sclerosing panencephalitis (SSPE) is a slowly progressing disease of the CNS in children which is caused by measles virus. Ferrets immunized with measles virus prior to inoculation with the cell associated, syncytiogenic D.R. strain of SSPE virus exhibit characteristics very similar to the human disease. Measles virus nucleocapsids are present, high measles antibody titers are found in the sera and inflammatory lesions are prominent in the brains. Measles virus specific immunoglobulin G (IgG) is present in the brain,and IgG/ albumin ratios indicate that the antibodies are synthesized within the CNS.

Presence of antibody in virus-infected brain cells of SSPE ferrets

1983 ◽  
Vol 41 ◽  
pp. 804-805
Author(s):  
Hannah R. Brown ◽  
Tammy L. Donato ◽  
Halldor Thormar
Keyword(s):  
Measles Virus ◽  
Plasma Cells ◽  
Subacute Sclerosing Panencephalitis ◽  
Protein A ◽  
Neutralizing Antibody ◽  
Brain Cells ◽  
Antibody Titers ◽  
A Cell ◽  
The Central Nervous System ◽  
The Brain

Measles virus specific immunoglobulin G (IgG) has been found in the brains of patients with subacute sclerosing panencephalitis (SSPE), a slowly progressing disease of the central nervous system (CNS) in children. IgG/albumin ratios indicate that the antibodies are synthesized within the CNS. Using the ferret as an animal model to study the disease, we have been attempting to localize the Ig's in the brains of animals inoculated with a cell associated strain of SSPE. In an earlier report, preliminary results using Protein A conjugated to horseradish peroxidase (PrAPx) (Dynatech Diagnostics Inc., South Windham, ME.) to detect antibodies revealed the presence of immunoglobulin mainly in antibody-producing plasma cells in inflammatory lesions and not in infected brain cells.In the present experiment we studied the brain of an SSPE ferret with neutralizing antibody titers of 1:1024 in serum and 1:512 in CSF at time of sacrifice 7 months after i.c. inoculation with SSPE measles virus-infected cells. The animal was perfused with saline and portions of the brain and spinal cord were immersed in periodate-lysine-paraformaldehyde (P-L-P) fixative. The ferret was not perfused with fixative because parts of the brain were used for virus isolation.

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