Ischemia-induced ventricular fibrillation in isolated perfused rat heart: role of alpha 1A -adrenoceptor mediated activation of protein kinase C

2001 ◽  
Vol 96 (1) ◽  
pp. 68-74 ◽  
Author(s):  
Ralph Tölg ◽  
Jürgen Schreieck ◽  
Thomas Kurz ◽  
Hugo A. Katus ◽  
Gert Richardt
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Ventricular Fibrillation ◽  
Rat Heart ◽  
Perfused Rat Heart ◽  
Isolated Perfused Rat Heart ◽  
Kinase C

The role of nitric oxide, reactive oxygen species, and protein kinase C in oxytocin-induced cardioprotection in ischemic rat heart

Peptides ◽  
2012 ◽  
Vol 37 (2) ◽  
pp. 314-319 ◽  
Author(s):  
Mahdieh Faghihi ◽  
Ali Mohammad Alizadeh ◽  
Vahid Khori ◽  
Mostafa Latifpour ◽  
Saeed Khodayari
Keyword(s):  
Nitric Oxide ◽  
Reactive Oxygen Species ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Rat Heart ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Kinase C

Effect of phorbol esters on the distribution and total activity of protein kinase c in the perfused rat heart

1989 ◽  
Vol 21 (12) ◽  
pp. 1415-1420 ◽  
Author(s):  
Stephen Rattigan ◽  
Aidan G.M. Davison ◽  
Perry J.F. Cleland ◽  
Michael G. Clark
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Rat Heart ◽  
Phorbol Esters ◽  
Total Activity ◽  
Perfused Rat Heart ◽  
Kinase C

Effeects of PMA on Protein Kinase C in Perfused Rat Heart

1988 ◽  
pp. 424-425
Author(s):  
A. G. M. Davidson ◽  
P. J. F. Cleland ◽  
S. Rattigan ◽  
M. G. Clark
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Rat Heart ◽  
Perfused Rat Heart ◽  
Kinase C

Role of protein kinase C in the regulation of steroidogenesis in the mouse Leydig cell

1986 ◽  
Vol 113 (1_Suppl) ◽  
pp. S63-S64
Author(s):  
A. K. MUKHOPADHYAY ◽  
H. G. BOHNET
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Leydig Cell ◽  
Kinase C ◽  
Mouse Leydig Cell

scholarly journals Dysregulation of protein kinase C in adult depression and suicide: evidence from postmortem brain studies

2021 ◽  
Author(s):  
Ghanshyam N Pandey ◽  
Anuradha Sharma ◽  
Hooriyah S Rizavi ◽  
Xinguo Ren
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Protein Expression ◽  
Mrna Expression ◽  
Postmortem Brain ◽  
Cortical Region ◽  
Cytosol Fraction ◽  
Kinase C ◽  
Pkc Isozymes

Abstract Background Several lines of evidence suggest the abnormalities of protein kinase C (PKC) signaling system in mood disorders and suicide based primarily on the studies of PKC and its isozymes in the platelets and postmortem brain of depressed and suicidal subjects. In this study we examined the role of PKC isozymes in depression and suicide. Methods We determined the protein and mRNA expression of various PKC isozymes in the prefrontal cortical region [Brodmann area 9 (BA9)] in 24 normal control (NC) subjects, 24 depressed suicide (DS) subjects and 12 depressed non-suicide (DNS) subjects. The levels of mRNA in the prefrontal cortex (PFC) were determined by qRT-PCR and the protein expression was determined by Western blotting. Results We observed a significant decrease in mRNA expression of PKCα, PKCβI, PKCδ and PKCε and decreased protein expression either in the membrane or the cytosol fraction of PKC isozymes - PKCα, PKCβI, PKCβII and PKCδ in DS and DNS subjects compared with NC subjects. Conclusions The current study provides detailed evidence of specific dysregulation of certain PKC isozymes in the postmortem brain of DS and DNS subjects and further supports earlier evidence for the role of PKC in the platelets and brain of adult and teenage depressed and suicidal population. This comprehensive study may lead to further knowledge of the involvement of PKC in the pathophysiology of depression and suicide.

scholarly journals Role of cadmium in activating nuclear protein kinase C and the enzyme binding to nuclear protein.

1992 ◽  
Vol 267 (28) ◽  
pp. 19824-19828
Author(s):  
C Block ◽  
S Freyermuth ◽  
D Beyersmann ◽  
A.N. Malviya
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Nuclear Protein ◽  
Enzyme Binding ◽  
Kinase C
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