Extracellular matrix gene expression correlates to left ventricular mass index after surgical induction of left ventricular hypertrophy

2001 ◽  
Vol 96 (4) ◽  
pp. 381-387 ◽  
Author(s):  
Andreas Schubert ◽  
Thomas Walther ◽  
Volkmar Falk ◽  
Christian Binner ◽  
Nadine Löscher ◽  
...  
Keyword(s):  
Gene Expression ◽  
Extracellular Matrix ◽  
Left Ventricular Hypertrophy ◽  
Left Ventricular Mass ◽  
Ventricular Hypertrophy ◽  
Left Ventricular Mass Index ◽  
Left Ventricular ◽  
Ventricular Mass Index ◽  
Matrix Gene ◽  
Ventricular Mass

The association of ankle brachial index with left ventricular hypertrophy and left ventricular mass index: the Dong-gu study

VASA ◽  
2013 ◽  
Vol 42 (4) ◽  
pp. 284-291 ◽  
Author(s):  
Seong-Woo Choi ◽  
Hye-Yeon Kim ◽  
Hye-Ran Ahn ◽  
Young-Hoon Lee ◽  
Sun-Seog Kweon ◽  
...  
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Left Ventricular Mass ◽  
Ventricular Hypertrophy ◽  
Left Ventricular Mass Index ◽  
Ankle Brachial Index ◽  
Intima Media Thickness ◽  
Left Ventricular ◽  
Baseline Survey ◽  
Ventricular Mass Index ◽  
Ventricular Mass

Background: To investigate the association between ankle-brachial index (ABI), left ventricular hypertrophy (LVH) and left ventricular mass index (LVMI) in a general population. Patients and methods: The study population consisted of 8,246 people aged 50 years and older who participated in the baseline survey of the Dong-gu Study conducted in Korea between 2007 and 2010. Trained research technicians measured LV mass using mode M ultrasound echocardiography and ABI using an oscillometric method. Results: After adjustment for risk factors and common carotid artery intima-media thickness (CCA-IMT) and the number of plaques, higher ABIs (1.10 1.19, 1.20 - 1.29, and ≥ 1.30) were significantly and linearly associated with high LVMI (1.10 - 1.19 ABI: β, 3.33; 95 % CI, 1.72 - 4.93; 1.20 - 1.29 ABI: β, 6.51; 95 % CI, 4.02 - 9.00; ≥ 1.30 ABI: β, 14.83; 95 % CI, 6.18 - 23.48). An ABI of 1.10 - 1.19 and 1.20 - 1.29 ABI was significantly associated with LVH (1.10 - 1.19 ABI: OR, 1.35; 95 % CI, 1.19 - 1.53; 1.20 - 1.29 ABI: OR, 1.59; 95 % CI, 1.31 - 1.92) and ABI ≥ 1.30 was marginally associated with LVH (OR, 1.73; 95 % CI, 0.93 - 3.22, p = 0.078). Conclusions: After adjustment for other cardiovascular variables and CCA-IMT and the number of plaques, higher ABIs are associated with LVH and LVMI in Koreans aged 50 years and older.

scholarly journals ARTERIAL HYPERTENSION ASSOCIATED WITH HYPERURICEMIA: FEATURES OF HEART DAMAGE

2020 ◽  
Vol 73 (5) ◽  
pp. 943-946
Author(s):  
Olha M. Chernatska ◽  
Liudmyla N. Prystupa ◽  
Hanna A. Fadieieva ◽  
Alina V. Liashenko ◽  
Yuliia O. Smiianova
Keyword(s):  
Uric Acid ◽  
Left Ventricular Hypertrophy ◽  
Arterial Hypertension ◽  
Left Ventricular Mass ◽  
Ventricular Hypertrophy ◽  
Left Ventricular Mass Index ◽  
Serum Uric Acid Level ◽  
Left Ventricular ◽  
Ventricular Mass Index ◽  
Ventricular Mass

The aim is the analysis of hyperuricemia influence on the heart features in patients with arterial hypertension. Materials and methods: We include 75 patients with arterial hypertension which were divided in two groups according to the level of uric acid in the blood, 30 practically healthy people. Patients from the I group (n = 40) had arterial hypertension and coexistent hyperuricemia; ІІ (n = 35) – arterial hypertension. Left ventricular mass index was determined for left ventricular hypertrophy confirmation. We used clinical, anthropometric, biochemical, instrumental, statistical method. Serum uric acid level was observed by the reaction with uricase. Left ventricular mass index was calculated as left ventricular mass to body surface area ratio. The results were analyzed statistically by SPSS 21 and Graphpad. Results: Left ventricular mass index was significantly higher (р = 0,0498) in patients from the І group (109,7 ± 3,21) g/m2 comparable with the ІІ (97,6 ± 5,35) g/m2 and increased in proportion to the biggest level of uric acid (r = 0,31; p = 0,04) in patients with arterial hypertension and hyperuricemia. Conclusions: Concentric and excentric left ventricular hypertrophy, increased left ventricular mass index proportionally to uric acid levels (r = 0,31; p = 0,04) is the confirmation of important role of hyperuricemia in the left ventricular hypertrophy development in patients with arterial hypertension.

scholarly journals KORELASI ANTARA TEKANAN DARAH DAN INDEKS MASSA VENTRIKEL KIRI (LEFT VENTRICULAR MASS INDEX) PADA PENDERITA HIPERTENSI DI RSUP PROF. DR. R. D. KANDOU MANADO

2015 ◽  
Vol 3 (1) ◽  
Author(s):  
Asdiana Nur ◽  
Fransiska Lintong ◽  
Maya Moningka
Keyword(s):  
Blood Pressure ◽  
Left Ventricular Hypertrophy ◽  
Left Ventricular Mass ◽  
Ventricular Hypertrophy ◽  
Left Ventricular Mass Index ◽  
Pressure Control ◽  
Left Ventricular ◽  
Ventricular Mass Index ◽  
Consecutive Sampling ◽  
Ventricular Mass

Abstract: Left ventricular hypertrophy (LVH) is target organ damage of cardiac with high prevalence in patients with hypertension. Increase of left ventricular mass was caused by increase in wall thickness as compensatory mechanism to minimize wall stress in response to elevated blood pressure. Left Ventricular Mass Index (LVMI) is one of echocardiography parameters used to diagnose LVH. The purpose of this study is to know the correlation between blood pressure and LVMI in patients with hypertension. A cross sectional study was performed at Cardiac Vascular and Brain Centre/ Central General Hospital of Prof. Dr. R. D Kandou. Sample was determined with consecutive sampling. Blood pressure of subjects were measurement and LVMI were taken from medical record. Data were analyzed used SPSS 21. Fifty one subjects, including 34 subjects with adequate blood pressure control and 17 subjects with inadequate blood pressure control are enrolled with ≥60 years old and men (64.7%) mostly found in this study. Pearson Correlation Test found a positive and significant correlation between systolic blood pressure and LVMI (r=0.488;p<0.05) while Spearman Correlation Test found a positive but not significant correlation between diastolic blood pressure and LVMI (r=0.226;p>0.05). In conclusion, there is a positive correlation between blood pressure and LVMI in patients with hypertension but a significant correlation was just found between systolic blood pressure and LVMI.Keywords: hypertension, Left ventricular hypertrophy (LVH), blood pressure, echocardiography, left ventricular mass index (LVMI)Abstrak: Hipertrofi ventrikel kiri (Left Ventricular Hypertrophy= LVH) merupakan kerusakan target organ jantung dengan prevalensi yang tinggi pada penderita hipertensi. Peningkatan massa ventrikel kiri disebabkan oleh penebalan dinding ventrikel kiri sebagai mekanisme kompensasi untuk meminimalkan tegangan dinding akibat respon terhadap peningkatan tekanan darah. Indeks massa ventrikel kiri (Left Ventricular Mass Index= LVMI) merupakan salah satu parameter ekokardiografi yang digunakan dalam mendiagnosa LVH. Tujuan dari penelitian ini adalah mengetahui korelasi antara tekanan darah dan LVMI pada penderita hipertensi. Penelitian dengan desain potong lintang dilakukan di instalasi pusat jantung dan pembuluh darah RSUP Prof Dr. R. D. Kandou. Sampel ditentukan secara consecutive sampling. Pengukuran tekanan darah dilakukan pada subyek penelitian dan LVMI diperoleh dari rekam medik. Data dianalisa menggunakan SPSS 21. Sebanyak 51 subyek penelitian, termasuk 34 subyek dengan hipertensi terkontrol dan 17 subyek dengan hipertensi tidak terkontrol, terdaftar pada penelitian ini dengan usia ≥60 tahun (39,2%) dan pria (64,7%)paling banyak ditemukan.Uji Korelasi Pearson menemukan tekanan darah sistolik mempunyai korelasi positif dan signifikan dengan LVMI (r=0,488;p<0,05) sedangkan uji Korelasi Spearman menemukan korelasi yang positif namun tidak signifikan antara tekanan darah diastolik dan LVMI (r=0,226;p>0,05). kesimpulan dari penelitian ini adalah terdapat korelasi positif antara tekanan darah dan LVMI pada penderita hipertensi, namun hubungan yang signifikan hanya ditemukan antara tekanan darah sistolik dan LVMI.Kata Kunci : hipertensi, hipertrofi ventrikel kiri, tekanan darah, ekokardiografi, indeks massa ventrikel kiri

scholarly journals Hyperhomocysteinemia accompany with metabolic syndrome increase the risk of left ventricular hypertrophy in rural Chinese

2020 ◽  
Author(s):  
Shasha Yu ◽  
Yintao Chen ◽  
Hongmei Yang ◽  
Xiaofan Guo ◽  
Liqiang Zheng ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Left Ventricular Hypertrophy ◽  
Left Ventricular Mass ◽  
Ventricular Hypertrophy ◽  
Left Ventricular Mass Index ◽  
Left Ventricular ◽  
Independent Effect ◽  
Cross Sectional ◽  
Ventricular Mass Index ◽  
Ventricular Mass

Abstract Background: To investigate the influence of hyperhomocysteinemia (HHcy) and metabolic syndrome (MetS) on left ventricular hypertrophy (LVH) in residents in rural Northeast China. Methods: We performed a cross-sectional baseline data analysis of 6837 subjects (mean age: 54±10 years) recruited from a rural area of China. Anthropometric indicators were measured according to standard methods. MetS was defined by the modified ATP III criteria. HHcy was defined according to the WHO standard: an Hcy level >15 μmol/L representing HHcy. Four groups were defined: non-HHcy & non-MetS, HHcy & non-MetS, MetS & non-HHcy and HHcy & MetS.Results: The left ventricular mass index for height2.7 (LVMH2.7) in both sexes was significantly higher in the HHcy & MetS group than in the non-HHcy & non-MetS group (females: 51.23±16.34 vs. 40.09±10.55 gm-2.7, P<0.001; males: 48.67±12.24 gm-2.7 vs. 42.42±11.38 gm-2.7, P<0.001). A similar result was observed in those groups when using the left ventricular mass index (LVMI) for body surface area to define LVH (females: 103.58±31.92 gm-2 vs. 86.63±20.47 gm-2, P<0.001; males: 106.10±24.69 gm-2 vs. 98.16±23.29 gm-2, P<0.001). The results of multiple regression analysis indicated that the HHcy & MetS group had a higher risk of LVH than the other three groups (OR: 1.628 for LVMI, P<0.001, OR: 2.433 for LVMH2.7, P<0.001). Moreover, subjects in the HHcy & non-MetS group [OR (95% CI): 1.297 (1.058, 1.591) for LVMI, P<0.05; OR (95% CI): 1.248 (1.044, 1.492) for LVMH2.7, P<0.05] also had a statistically greater risk of LVH than subjects in the non-HHcy & non-MetS group. The HHcy & non-MetS group was also found to be significantly and independently associated with LVH.Conclusion: Hyperhomocysteinemia has an independent effect on LVH. The combined effect of MetS and hyperhomocysteinemia might increase the strength of the abovementioned effects.

scholarly journals Hyperhomocysteinemia accompany with metabolic syndrome increase the risk of left ventricular hypertrophy in rural Chinese

2019 ◽  
Author(s):  
Shasha Yu ◽  
Yintao Chen ◽  
Hongmei Yang ◽  
Xiaofan Guo ◽  
Liqiang Zheng ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Left Ventricular Hypertrophy ◽  
Left Ventricular Mass ◽  
Ventricular Hypertrophy ◽  
Left Ventricular Mass Index ◽  
Left Ventricular ◽  
Independent Effect ◽  
Cross Sectional ◽  
Ventricular Mass Index ◽  
Ventricular Mass

Abstract Background: To investigate the influence of hyperhomocysteinemia (HHcy) and metabolic syndrome (MetS) on left ventricular hypertrophy (LVH) in residents in rural Northeast China. Methods: We performed a cross-sectional baseline data analysis of 6837 subjects (mean age: 54±10 years) recruited from a rural area of China. Anthropometric indicators were measured according to standard methods. MetS was defined by the modified ATP III criteria. HHcy was defined according to the WHO standard: an Hcy level >15 μmol/L representing HHcy. Four groups were defined: non-HHcy & non-MetS, HHcy & non-MetS, MetS & non-HHcy and HHcy & MetS. Results: The left ventricular mass index for height2.7 (LVMH2.7) in both sexes was significantly higher in the HHcy & MetS group than in the non-HHcy & non-MetS group (females: 51.23±16.34 vs. 40.09±10.55 gm-2.7, P<0.001; males: 48.67±12.24 gm-2.7 vs. 42.42±11.38 gm-2.7, P<0.001). A similar result was observed in those groups when using the left ventricular mass index for body surface area (LVMI) to define LVH (females: 103.58±31.92 gm-2 vs. 86.63±20.47 gm-2, P<0.001; males: 106.10±24.69 gm-2 vs. 98.16±23.29 gm-2, P<0.001). The results of multiple regression analysis indicated that the HHcy & MetS group had a higher risk of LVH than the other three groups (OR: 1.628 for LVMI, P<0.001, OR: 2.433 for LVMH2.7, P<0.001). Moreover, subjects in the HHcy & non-MetS group [OR (95% CI): 1.297 (1.058, 1.591) for LVMI, P<0.05; OR (95% CI): 1.248 (1.044, 1.492) for LVMH2.7, P<0.05] also had a statistically greater risk of LVH than subjects in the non-HHcy & non-MetS group. The HHcy & non-MetS group was also found to be significantly and independently associated with LVH. Conclusion: Hyperhomocysteinemia has an independent effect on LVH. The combined effect of MetS and hyperhomocysteinemia might increase the strength of the abovementioned effects.

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