Cross-talk between angiotensin II and interleukin-6-induced signaling through Stat3 transcription factor

1998 ◽  
Vol 93 (0) ◽  
pp. s026-s029 ◽  
Author(s):  
G.J. Bhat ◽  
K.M. Baker
Keyword(s):  
Transcription Factor ◽  
Angiotensin Ii ◽  
Cross Talk ◽  
Interleukin 6 ◽  
Stat3 Transcription Factor

Cellular dynamics of the STAT3 transcription factor

Cytokine ◽  
2009 ◽  
Vol 48 (1-2) ◽  
pp. 127
Author(s):  
Velasco Cimica ◽  
Janaki Iyer ◽  
Nancy C. Reich
Keyword(s):  
Transcription Factor ◽  
Cellular Dynamics ◽  
Stat3 Transcription Factor

scholarly journals Disruption of Nuclear Factor-Interleukin-6, a Transcription Factor, Results in Severe Mycobacterial Infection

2001 ◽  
Vol 158 (2) ◽  
pp. 361-366 ◽  
Author(s):  
Isamu Sugawara ◽  
Satoru Mizuno ◽  
Hiroyuki Yamada ◽  
Makoto Matsumoto ◽  
Shizuo Akira
Keyword(s):  
Transcription Factor ◽  
Interleukin 6 ◽  
Mycobacterial Infection ◽  
Nuclear Factor

scholarly journals Endoplasmic reticulum and oxidant stress mediate nuclear factor-κB activation in the subfornical organ during angiotensin II hypertension

2015 ◽  
Vol 308 (10) ◽  
pp. C803-C812 ◽  
Author(s):  
Colin N. Young ◽  
Anfei Li ◽  
Frederick N. Dong ◽  
Julie A. Horwath ◽  
Catharine G. Clark ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Endoplasmic Reticulum ◽  
Transcription Factor ◽  
Angiotensin Ii ◽  
Er Stress ◽  
Bioluminescence Imaging ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Ang Ii ◽  
Arterial Blood

Endoplasmic reticulum (ER) stress and reactive oxygen species (ROS) generation in the brain circumventricular subfornical organ (SFO) mediate the central hypertensive actions of Angiotensin II (ANG II). However, the downstream signaling events remain unclear. Here we tested the hypothesis that angiotensin type 1a receptors (AT1aR), ER stress, and ROS induce activation of the transcription factor nuclear factor-κB (NF-κB) during ANG II-dependent hypertension. To spatiotemporally track NF-κB activity in the SFO throughout the development of ANG II-dependent hypertension, we used SFO-targeted adenoviral delivery and longitudinal bioluminescence imaging in mice. During low-dose infusion of ANG II, bioluminescence imaging revealed a prehypertensive surge in NF-κB activity in the SFO at a time point prior to a significant rise in arterial blood pressure. SFO-targeted ablation of AT1aR, inhibition of ER stress, or adenoviral scavenging of ROS in the SFO prevented the ANG II-induced increase in SFO NF-κB. These findings highlight the utility of bioluminescence imaging to longitudinally track transcription factor activation during the development of ANG II-dependent hypertension and reveal an AT1aR-, ER stress-, and ROS-dependent prehypertensive surge in NF-κB activity in the SFO. Furthermore, the increase in NF-κB activity before a rise in arterial blood pressure suggests a causal role for SFO NF-κB in the development of ANG II-dependent hypertension.

scholarly journals Angiotensin II activates nuclear transcription factor-κB through AT1 and AT2 receptors11See Editorial by Luft, p. 2272.

2002 ◽  
Vol 61 (6) ◽  
pp. 1986-1995 ◽  
Author(s):  
Gunter Wolf ◽  
Ulrich Wenzel ◽  
Kevin D. Burns ◽  
Raymond C. Harris ◽  
Rolf A.K. Stahl ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Angiotensin Ii ◽  
Nuclear Transcription Factor

scholarly journals Cross-talk between angiotensin II and IGF-1-induced connexin 43 expression in human saphenous vein smooth muscle cells

2011 ◽  
Vol 15 (8) ◽  
pp. 1695-1702 ◽  
Author(s):  
Guanghong Jia ◽  
Anshu Aggarwal ◽  
Amanuel Yohannes ◽  
Deepak M. Gangahar ◽  
Devendra K. Agrawal
Keyword(s):  
Smooth Muscle ◽  
Angiotensin Ii ◽  
Smooth Muscle Cells ◽  
Cross Talk ◽  
Saphenous Vein ◽  
Connexin 43 ◽  
Muscle Cells ◽  
Human Saphenous Vein
Sign in / Sign up

Export Citation Format

Share Document