Effect of different degrees of moderate iron deficiency on the activities of tricarboxylic acid cycle enzymes, and the cytochrome oxidase, and the iron, copper, and zinc concentration in rat tissues (Einfluß moderater Eisenmangelsituationen auf die Aktivitäten der Citratzyklusenzyme und der Cytochrom-Oxidase sowie die Eisen-, Kupfer- und Zinkgehalte in Rattengeweben)

1998 ◽  
Vol 37 (3) ◽  
pp. 260-268 ◽  
Author(s):  
G.I. Stangl ◽  
M. Kirchgeßner
Keyword(s):  
Iron Deficiency ◽  
Cytochrome Oxidase ◽  
Zinc Concentration ◽  
Tricarboxylic Acid Cycle ◽  
Tricarboxylic Acid ◽  
Rat Tissues ◽  
Acid Cycle ◽  
Iron Copper ◽  
Copper And Zinc

scholarly journals Effect of Iron-deficiency on Iron, Copper and Zinc Concentration in Rat Tissues

1980 ◽  
Vol 33 (4) ◽  
pp. 253-258
Author(s):  
Kazuharu SUZUKI ◽  
Yusuke KANKE ◽  
Shiro GOTO
Keyword(s):  
Iron Deficiency ◽  
Zinc Concentration ◽  
Rat Tissues ◽  
Iron Copper ◽  
Copper And Zinc

Effects of iron deficiency and training on mitochondrial enzymes in skeletal muscle

1987 ◽  
Vol 62 (6) ◽  
pp. 2442-2446 ◽  
Author(s):  
W. T. Willis ◽  
G. A. Brooks ◽  
S. A. Henderson ◽  
P. R. Dallman
Keyword(s):  
Skeletal Muscle ◽  
Iron Deficiency ◽  
Cytochrome C ◽  
Endurance Training ◽  
Tricarboxylic Acid Cycle ◽  
Interactive Effect ◽  
Tricarboxylic Acid ◽  
Mitochondrial Enzymes ◽  
Acid Cycle ◽  
Iron Deficient

We measured mitochondrial enzyme activities in skeletal muscle under conditions of iron deficiency and endurance training to assess the effects of these interventions on the contents and proportions of non-iron-containing and iron-dependent enzymes and proteins. Male Sprague-Dawley rats, 21 days of age, received a diet containing either 6 (iron deficient) or 50 mg iron/kg diet (iron sufficient). At 35 days of age animals were subdivided into sedentary and endurance training groups (running at 0.7 mph, 0% grade, 45 min/day, 6 days/wk). By 70 days of age, iron deficiency had decreased gastrocnemius muscle cytochrome c by 62% in sedentary animals. In contrast, the activities of tricarboxylic acid cycle enzymes were increased, remained unchanged or were slightly decreased, indicating that iron deficiency markedly altered mitochondrial composition. Endurance training increased cytochrome c (35%), tricarboxylic acid cycle enzymes (approximately 15%), and manganese superoxide dismutase (33%) in iron-deficient rats, whereas the same exercise regimen had no effect on the skeletal muscle of iron-sufficient animals. The interactive effect of dietary iron deficiency and mild exercise on mitochondrial enzymes suggests that adaptation to a training stimulus is, to some extent, geared to the relationship between the energy demand of exercise and the capacity for O2 transport and utilization.

Effect of mercuric chloride on some kidney enzymes in chow-fed and sucrose-fed rats

1960 ◽  
Vol 198 (1) ◽  
pp. 187-190 ◽  
Author(s):  
V. Shore ◽  
B. Shore
Keyword(s):  
Alkaline Phosphatase ◽  
Cytochrome Oxidase ◽  
Mercuric Chloride ◽  
Tricarboxylic Acid Cycle ◽  
Succinic Dehydrogenase ◽  
Tricarboxylic Acid ◽  
Acid Cycle ◽  
Enzyme Systems ◽  
Rat Kidneys ◽  
Ketoglutarate Dehydrogenase

Rats given a diet of sucrose and vitamins for 3 weeks or more develop a tolerance to mercuric chloride greater than that of chow-fed rats. Comparison of several enzyme systems (tricarboxylic acid cycle, succinic dehydrogenase, cytochrome oxidase, α-ketoglutarate dehydrogenase, alkaline phosphatase, cathepsins and ß-glucuronidase) in chow-fed and sucrose-fed rats indicated no significant differences in activities. After 3 mg HgCl2/kg i.v., notable differences in the extent of inhibition of tricarboxylic acid enzyme systems were observed. Twenty-four hours after such an injection, kidneys of chow-fed rats were seriously hampered in their ability to perform biological energy transformations. Oxidation and phosphorylation by sucrose-fed rat kidneys were considerably less inhibited.

scholarly journals Effects of sevoflurane anesthesia and abdominal surgery on the systemic metabolome: a prospective observational study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yiyong Wei ◽  
Donghang Zhang ◽  
Jin Liu ◽  
Mengchan Ou ◽  
Peng Liang ◽  
...  
Keyword(s):  
Abdominal Surgery ◽  
General Anesthesia ◽  
Tricarboxylic Acid Cycle ◽  
Tricarboxylic Acid ◽  
Metabolic Changes ◽  
Sevoflurane Anesthesia ◽  
Glutamate Metabolism ◽  
Acid Cycle ◽  
Link Type ◽  
The Mean

Abstract Background Metabolic status can be impacted by general anesthesia and surgery. However, the exact effects of general anesthesia and surgery on systemic metabolome remain unclear, which might contribute to postoperative outcomes. Methods Five hundred patients who underwent abdominal surgery were included. General anesthesia was mainly maintained with sevoflurane. The end-tidal sevoflurane concentration (ETsevo) was adjusted to maintain BIS (Bispectral index) value between 40 and 60. The mean ETsevo from 20 min after endotracheal intubation to 2 h after the beginning of surgery was calculated for each patient. The patients were further divided into low ETsevo group (mean − SD) and high ETsevo group (mean + SD) to investigate the possible metabolic changes relevant to the amount of sevoflurane exposure. Results The mean ETsevo of the 500 patients was 1.60% ± 0.34%. Patients with low ETsevo (n = 55) and high ETsevo (n = 59) were selected for metabolomic analysis (1.06% ± 0.13% vs. 2.17% ± 0.16%, P < 0.001). Sevoflurane and abdominal surgery disturbed the tricarboxylic acid cycle as identified by increased citrate and cis-aconitate levels and impacted glycometabolism as identified by increased sucrose and D-glucose levels in these 114 patients. Glutamate metabolism was also impacted by sevoflurane and abdominal surgery in all the patients. In the patients with high ETsevo, levels of L-glutamine, pyroglutamic acid, sphinganine and L-selenocysteine after sevoflurane anesthesia and abdominal surgery were significantly higher than those of the patients with low ETsevo, suggesting that these metabolic changes might be relevant to the amount of sevoflurane exposure. Conclusions Sevoflurane anesthesia and abdominal surgery can impact principal metabolic pathways in clinical patients including tricarboxylic acid cycle, glycometabolism and glutamate metabolism. This study may provide a resource data for future studies about metabolism relevant to general anaesthesia and surgeries. Trial registration www.chictr.org.cn. identifier: ChiCTR1800014327.

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