Acetaminophen overdose and acute liver failure: Modern management

1997 ◽  
Vol 34 (3) ◽  
pp. 206-214
Author(s):  
A. J. Makin ◽  
R. Williams
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Acetaminophen Overdose ◽  
Modern Management

scholarly journals Pharmacokinetics of Acetaminophen-Protein Adducts in Adults with Acetaminophen Overdose and Acute Liver Failure

2009 ◽  
Vol 37 (8) ◽  
pp. 1779-1784 ◽  
Author(s):  
Laura P. James ◽  
Lynda Letzig ◽  
Pippa M. Simpson ◽  
Edmund Capparelli ◽  
Dean W. Roberts ◽  
...  
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Protein Adducts ◽  
Acetaminophen Overdose

Modern Management of Acute Liver Failure

2018 ◽  
Vol 47 (2) ◽  
pp. 313-326 ◽  
Author(s):  
Ruben Khan ◽  
Sean Koppe
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Modern Management

scholarly journals Quality of life is significantly impaired in long-term survivors of acute liver failure and particularly in acetaminophen-overdose patients

2013 ◽  
Vol 19 (9) ◽  
pp. 991-1000 ◽  
Author(s):  
Amol S. Rangnekar ◽  
Caitlyn Ellerbe ◽  
Valerie Durkalski ◽  
Brendan McGuire ◽  
William M. Lee ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Acetaminophen Overdose ◽  
Long Term Survivors

scholarly journals High Volume Plasma Exchange in Acute Liver Failure: A Brief Review

2021 ◽  
Vol 22 (5) ◽  
pp. 102-105
Author(s):  
Matthew Rockstrom ◽  
◽  
Jonathan Rice ◽  
Tomio Tran ◽  
Anna Neumeier
Keyword(s):  
Suicide Attempt ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Plasma Exchange ◽  
High Volume ◽  
Altered Mental Status ◽  
The United States ◽  
Acetaminophen Overdose ◽  
Standard Medical Therapy ◽  
Transplant Candidates

Acute liver failure (ALF) is characterized by acute liver injury, coagulopathy, and altered mental status. Acetaminophen overdose contributes to almost half the cases of ALF in the United States. In the era of liver transplantation, mortality associated with this condition has improved dramatically. However, many patients are not transplant candidates including many who present with overt suicide attempt from acetaminophen overdose. High volume plasma exchange (HVP) is a novel application of plasma exchange. Prior research has shown that HVP can correct the pathophysiologic derangements underlying ALF. A randomized control trial demonstrated improved transplant-free survival when HVP was added to standard medical therapy. In this case, we examine a patient who presented to the intensive care unit with ALF caused by intentional acetaminophen overdose. She was denied transplant due to overt suicide attempt, was treated with HVP, and made a rapid recovery, eventually discharged to inpatient psychiatry and then home.

Sign in / Sign up

Export Citation Format

Share Document