Primitive neuroectodermal tumor involving the frontal skull base in an infant

Jun Niwa; Norihiko Shimoyama; Yoshio Takahashi

doi:10.1007/s003810100469

Primitive neuroectodermal tumor involving the frontal skull base in an infant

Child s Nervous System ◽

10.1007/s003810100469 ◽

2001 ◽

Vol 17 (9) ◽

pp. 570-574 ◽

Cited By ~ 11

Author(s):

Jun Niwa ◽

Norihiko Shimoyama ◽

Yoshio Takahashi

Keyword(s):

Skull Base ◽

Primitive Neuroectodermal Tumor ◽

Neuroectodermal Tumor ◽

Frontal Skull Base

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Peripheral facial palsy, the only presentation of a primitive neuroectodermal tumor of the skull base

International Journal of Surgery Case Reports ◽

10.1016/j.ijscr.2015.12.019 ◽

2016 ◽

Vol 19 ◽

pp. 47-50

Author(s):

Hyung Jin Kim ◽

Ben Kang ◽

Eun Young Joo ◽

Eun Young Kim ◽

Young Se Kwon

Keyword(s):

Skull Base ◽

Facial Palsy ◽

Primitive Neuroectodermal Tumor ◽

Neuroectodermal Tumor ◽

Peripheral Facial Palsy

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Membranous alterations in the cytoplasm and nucleus in a primitive neuroectodermal tumor of the brain

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100084016 ◽

1978 ◽

Vol 36 (2) ◽

pp. 628-629

Author(s):

C. N. Sun ◽

C. Araoz ◽

H. J. White

Keyword(s):

Nuclear Envelope ◽

Tumor Cells ◽

Osmium Tetroxide ◽

Primitive Neuroectodermal Tumor ◽

Uranyl Acetate ◽

Neuroectodermal Tumor ◽

Annulate Lamellae ◽

Lead Citrate ◽

Thin Sections ◽

The Brain

The ultrastructure of a cerebral primitive neuroectodermal tumor has been reported previously. In the present case, we will present some unusual previously unreported membranous structures and alterations in the cytoplasm and nucleus of the tumor cells.Specimens were cut into small pieces about 1 mm3 and immediately fixed in 4% glutaraldehyde in phosphate buffer for two hours, then post-fixed in 1% buffered osmium tetroxide for one hour. After dehydration, tissues were embedded in Epon 812. Thin sections were stained with uranyl acetate and lead citrate.In the cytoplasm of the tumor cells, we found paired cisternae (Fig. 1) and annulate lamellae (Fig. 2) noting that the annulate lamellae were sometimes associated with the outer nuclear envelope (Fig. 3). These membranous structures have been reported in other tumor cells. In our case, mitochondrial to nuclear envelope fusions were often noted (Fig. 4). Although this phenomenon was reported in an oncocytoma, their frequency in the present study is quite striking.

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