Assessment of brain perfusion by 99m Tc-HMPAO SPECT in akinetic mutism due to high-dose intravenous methotrexate therapy

1997 ◽  
Vol 13 (10) ◽  
pp. 560-562 ◽  
Author(s):  
N. I. Karabacak ◽  
Gulyuz Ozturk ◽  
Kivilcim Gucuyener ◽  
Nahide Gokcora ◽  
Turkiz Gursel
Keyword(s):  
Brain Perfusion ◽  
Methotrexate Therapy ◽  
Akinetic Mutism ◽  
High Dose ◽  
Hmpao Spect

Vergleich von Blutfluß und Benzodiazepin-Rezeptorverteilung bei fokaler Epilepsie: Vorläufige Ergebnisse einer SPECT-Studie

1989 ◽  
Vol 28 (05) ◽  
pp. 181-186
Author(s):  
A. Ludolph ◽  
O. Schober ◽  
G. Lottes ◽  
I. Böttger ◽  
H.-F. Beer ◽  
...  
Keyword(s):  
Human Brain ◽  
Receptor Binding ◽  
Brain Area ◽  
Brain Perfusion ◽  
Partial Epilepsy ◽  
Cerebral Lesion ◽  
Receptor Ligand ◽  
Receptor Mapping ◽  
Hmpao Spect ◽  
99Mtc Hmpao

99mTc-HMPAO-SPECT and SPECT with the 123I-labelled benzodiazepine (Bz) receptor ligand Ro 16-0154 were performed in 10 patients suffering from partial epilepsy, without cerebral lesion in MRT or CT. 2 h p.i. of Ro 16-0154 the distribution of activity correlated with the known distribution of Bz- receptors in the human brain. Perfusion and receptor-binding were found decreased in 7 patients of each study in the suspicious brain-area. 123l-labelled Ro 16-0154 is suitable for Bz-receptor mapping by SPECT. The decrease of Bz-receptor binding in epileptic foci, as described in PET-studies, was also detected by SPECT in 7 of 10 patients.

Atlas of 99mTc-HMPAO SPECT brain perfusion in pediatric brain disorders

2021 ◽  
Vol 2 (2) ◽  
Author(s):  
Saleh A Othman ◽  
Keyword(s):  
Blood Flow ◽  
Neuronal Activity ◽  
Pediatric Patients ◽  
Brain Perfusion ◽  
Brain Disorders ◽  
Hmpao Spect ◽  
Perfusion Scan ◽  
Pediatric Brain ◽  
The Brain ◽  
99Mtc Hmpao

Background: Blood flow to the brain is in parallel with brain metabolism in almost all brain disorders except in brain tumors and therefore regional cerebral blood flow can be used as a marker of metabolic brain activity and hence it is closely linked to neuronal activity, the activity distribution is presumed to reflect neuronal activity levels in different areas of the brain. Purpose: The aim of this work is to demonstrate to pediatrician in general and pediatric neurologist in particular the variations in cerebral perfusion during normal development which should be taken into consideration at the time of interpreting SPECT brain perfusion scan in different pediatric brain disorders. Method: Brain SPECT was performed 10 minutes after an intravenous injection of 11.1 MBq/kg (0.3 mCi/kg), and the minimum dose is 185 MBq (5 mCi) of 99mTc-HMPAO (4). Results: This was a retrospective analysis of SPECT brain perfusion scan of pediatric patients performed between October 2015 and December 2019 at our institution. We selected normal and abnormal studies in pediatric population with age range (5 months - 14 years). Conclusion: Although anatomic cross sectional imaging give details of neurological structural changes, SPECT perfusion mirrors indirectly both metabolic and neuronal activity changes. Therefore, accurate interpretation of SPECT perfusion will consolidate its role as part of the diagnostic protocol and used when the findings of other imaging modalities do not explain the symptoms or fail partially or completely in determining the etiology of brain disorders in pediatric patients.

Short-term, High-dose Methotrexate Therapy in a Case of Severe Psoriatic Arthritis

Rheumatology ◽  
1988 ◽  
Vol 27 (2) ◽  
pp. 160-162 ◽  
Author(s):  
E. EECKHOUT ◽  
E. SUYS ◽  
P. BUYDENS ◽  
S. VAN BELLE ◽  
L. A. VERBRUGGEN
Keyword(s):  
Psoriatic Arthritis ◽  
Methotrexate Therapy ◽  
High Dose ◽  
High Dose Methotrexate ◽  
Short Term ◽  
Dose Methotrexate

Early Recognition of Renal Toxicity of High-dose Methotrexate Therapy

2008 ◽  
Vol 30 (12) ◽  
pp. 950-952 ◽  
Author(s):  
Theodore Scott Nowicki ◽  
Kari Bjornard ◽  
David Kudlowitz ◽  
Claudio Sandoval ◽  
Somasundaram Jayabose
Keyword(s):  
Renal Toxicity ◽  
Early Recognition ◽  
Methotrexate Therapy ◽  
High Dose ◽  
High Dose Methotrexate ◽  
Dose Methotrexate

Acute urticaria and hepatitis complicating high-dose methotrexate therapy

1995 ◽  
Vol 24 (2) ◽  
pp. 137-140 ◽  
Author(s):  
Zakiya Al-Lamki ◽  
Eileen Thomas ◽  
Nagwa El-Banna ◽  
Norman Jaffe
Keyword(s):  
Methotrexate Therapy ◽  
High Dose ◽  
High Dose Methotrexate ◽  
Acute Urticaria ◽  
Dose Methotrexate

Simple Visual Analysis of Brain Perfusion on HMPAO SPECT Predicts Early Outcome in Acute Stroke

Stroke ◽  
1996 ◽  
Vol 27 (9) ◽  
pp. 1537-1542 ◽  
Author(s):  
Andrei V. Alexandrov ◽  
Sandra E. Black ◽  
Lisa E. Ehrlich ◽  
Christopher F. Bladin ◽  
Liliana T. Smurawska ◽  
...  
Keyword(s):  
Acute Stroke ◽  
Visual Analysis ◽  
Brain Perfusion ◽  
Early Outcome ◽  
Hmpao Spect

scholarly journals P0008CASE REPORT: METABOLIC ALKALOSIS RESULTING IN RESPIRATORY COMPROMISE IN A PATIENT UNDERGOING HIGH DOSE METHOTREXATE THERAPY

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Darragh O'Donoghue ◽  
Heather Truong ◽  
Heidi Finnes ◽  
Jennifer McDonald ◽  
Nelson Leung
Keyword(s):  
Metabolic Alkalosis ◽  
B Cell Lymphoma ◽  
Methotrexate Therapy ◽  
High Dose ◽  
Close Monitoring ◽  
High Dose Methotrexate ◽  
Respiratory Compromise ◽  
Dose Methotrexate ◽  
Adequate Hydration ◽  
Bicarbonate Infusion

Abstract Background and Aims High dose Methotrexate (HDMTX) is an important component of several modern oncological/haematological treatment protocols due to its central nervous system penetrance. Nephrotoxicity represents a significant adverse effect and can limit therapeutic options. Therefore, strategies to prevent this are paramount. Urinary alkalinisation and large volume resuscitation to maintain adequate hydration and urine output are the typical strategies. Urinary alkalinisation prevents tubular precipitation of methotrexate and therefore, a strict urinary pH target of 7 is maintained via a continuous bicarbonate infusion. Method We describe a case report, of Iatrogenic metabolic alkalosis leading to respiratory compromise in a patient receiving HDMTX from Mayo Clinic, Rochester. Results We present the case of a 76-year-old woman with a Diffuse Large B-Cell Lymphoma with CNS involvement who presented for elective admission for her 1st cycle of HDMTX. She received 7g of Methotrexate at dosing of 8 g/m2. She received the standard urinary alkalinisation with pre- and post-hydration. Her baseline HCO3- was 28 mEq/L. Her 48 hour MTX level was elevated at 1.2 so the urinary alkalinisation protocol was continued until <0.1 mcmol/L. On day 4, she developed frequent episodes of apnoea. Her ABG demonstrated a metabolic alkalaemia pH 7.54, pCO 53, pO2 91, HCO3 45. She was transferred to the ICU for close monitoring. Her bicarbonate infusion was discontinued and she received acetazolamide. Her bicarbonate improved to 31 after 12 hours. She had a significant improvement in her respiratory status with no further episodes of apnoea. Her bicarbonate infusion was restarted due to elevated MTX levels. She was discharged home with no further complications. Conclusion Iatrogenic Metabolic alkalosis leading to respiratory compromise represents a rare but important complication of urinary alkalinsation protocols for High-dose Methotrexate therapy.

scholarly journals Kinetics of Plasma Total Homocysteine in Patients Receiving High-Dose Methotrexate Therapy

1998 ◽  
Vol 44 (9) ◽  
pp. 1987-1989 ◽  
Author(s):  
Anne Berit Guttormsen ◽  
Per Magne Ueland ◽  
Per Eystein Lønning ◽  
Olav Mella ◽  
Helga Refsum
Keyword(s):  
Methotrexate Therapy ◽  
High Dose ◽  
High Dose Methotrexate ◽  
Dose Methotrexate ◽  
Total Homocysteine ◽  
Kinetics Of ◽  
Plasma Total Homocysteine
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