Gastrointestinal blood flow in the red Irish lord, Hemilepidotus hemilepidotus : long-term effects of feeding and adrenergic control

2000 ◽  
Vol 170 (2) ◽  
pp. 145-152 ◽  
Author(s):  
M. Axelsson ◽  
H. Thorarensen ◽  
A. P. (Tony) Farrell ◽  
S. Nilsson
Keyword(s):  
Blood Flow ◽  
Long Term Effects ◽  
Adrenergic Control ◽  
Gastrointestinal Blood Flow

The Immediate And Long-Term Effects of Shexiang Tongxin Dropping Pill On Coronary Slow Flow: Study Protocol For A Randomized Double-Blind Placebo-Controlled Trial

2021 ◽  
Author(s):  
Birong Liu ◽  
Yong Liu ◽  
Liyong Ma ◽  
Jia Liu ◽  
Jingen Li ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Blood Flow ◽  
Blood Stasis ◽  
Blood Stasis Syndrome ◽  
Controlled Study ◽  
Slow Flow ◽  
Long Term Effects ◽  
Coagulation Function ◽  
Coronary Slow Flow

Abstract Background: Coronary slow flow (CSF) is a phenomenon characterized by delayed contrast medium progression in angiography in the absence of obstructive coronary epicardial disease. However, there is currently no definite effective therapy. A small sample self-controlled study had suggested an immediate improvement in coronary slow blood flow by Shexiang Tongxin Dropping Pills (STDP). But high-quality evidences on drug dosage, medication cycle and long-term effects are still lacking while the mechanism of STDP remains unclear. Methods: This study is a randomized, double-blinded, and placebo-controlled clinical trial. A total of 64 CSF patients diagnosed by coronary angiography will be randomly allocated into the test group, using STDP, and the control group, using placebo. The main efficacy indicators for immediate effects include thrombolysis in myocardial infarction (TIMI) blood flow grading and corrected TIMI frame count. Long-term effects will be evaluated by the comparison of cardiac radionuclide score, and patient condition such as angina readmission rate and angina scale. The safety indicators include a routine complete blood count, liver and renal function test, cardiac markers (including TnI, CK-MB, Myo), NT-proBNP, coagulation function, 12-lead electrocardiogram, and echocardiography. All adverse events during the trial will be recorded. Moreover, endothelial factors (including ET-1, NO, eNOS, iNOS), inflammatory factors (including adropin, IL-6, IL-1, IL-18, TNF-α, Lp-PLA2, hs-CRP) will be observed. Blood stasis syndrome (including platelet activation factors such as CD62 and CD63, coagulation function and blood stasis syndrome score) will be evaluated.Trial registration: Chinese Clinical Trial Registry, ChiCTR2000035167. Registered on August 2, 2020. http://www.chictr.org.cn/showproj.aspx?proj=57349

Abstract TP115: Cerebral Hemodynamic Changes in Military Personnel With Long-term Effects of Concussions

Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
Alexander Razumovsky ◽  
Melissa Rampino ◽  
Efim Kouperberg ◽  
Donna M Neuges ◽  
Thomas J DeGraba ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Head Injuries ◽  
Vascular Wall ◽  
Cerebral Hemodynamics ◽  
Long Term Effects ◽  
Luminal Narrowing ◽  
Lumen Narrowing ◽  
Blood Flow Velocities

Service members (SMs) suffer from repeated exposure to concussions or mild TBI, which can disrupt cerebral blood flow. This effect is seen in the acute phase of TBI, but the development of vascular wall abnormalities, which can lead to luminal narrowing and abnormally elevated cerebral blood flow velocities (CBFV), has not been studied in the post concussive phase. The purpose of this study was to evaluate the transcranial Doppler (TCD) determined incidence of abnormal cerebral hemodynamics in patients with long-term effects of mTBI. Material and Methods: TCD recordings of mean CBFV in cm/sec and Pulsatility Indices (PI) were recorded from 431 SMs (9 females; ages 24-54, mean age 39.2 ± 6.4 years) who were admitted to the National Intrepid Center of Excellence 4-week Interdisciplinary Outpatient Program. TCD data were analyzed to determine whether SMs exhibited abnormal CBFV s in the middle cerebral artery, internal carotid artery (ICA), and basilar artery. All subjects consented to protocol #362504 prior to any data collection or analysis. Two standard deviation from the mean CBFV in any direction labeled as an abnormal and PI was assumed normal with values between 0.7 and 0.9 Patients with one or more vessels with abnormal CBFV’s and PI’s were labeled as abnormal. Results: Average time since last TBI was 5.1 ± 3.4 years. We observed abnormal CBFV values in 33% of SMs. 149 (35%) and 48 (11%) demonstrated abnormally high CBFV and PIs in one or more vessels, respectively. Abnormal CBFV was observed most frequently in the ICA (48%). Majority of studied patients had patchy pattern of abnormal data presented in one or few vessels. The presence of abnormal cerebral hemodynamics was inversely related to the time since the last mTBI exposure: the likelihood of abnormal CBFV values deceased with increasing time since last head injury was sustained but was still present. Conclusions: Our data reveal that a large proportion of SMs have elevated CBFVs following mTBI exposure in many years after last mTBI. We believe that head injuries due to combat and training blast and blunt force trauma exposure cause early atherosclerotic or fibrotic changes in the large vessel walls of the Circle of Willis, which results in vascular lumen narrowing and increased CBFV’s.

scholarly journals Acute and Chronic Periocular Massage for Ocular Blood Flow and Vision: a Randomized Controlled Trial

2021 ◽  
Vol 14 (2) ◽  
pp. 5-13
Author(s):  
Naoyuki Hayashi, PhD ◽  
Lanfei Du, MSc
Keyword(s):  
Blood Flow ◽  
Visual Acuity ◽  
Vascular Function ◽  
Controlled Trial ◽  
Ocular Blood Flow ◽  
Control Group ◽  
Long Term Effects ◽  
Short Term ◽  
Before And After

Introduction: The ocular blood flow (OBF) is responsible for supplying nutrition to the retina, which plays a fundamental role in visual function. Massage is expected to improve the blood flow and, consequently, vascular function. The aim of this study was to determine the shortterm and long-term effects of periocular massage on OBF and visual acuity. Methods: The OBF and visual acuity were measured in 40 healthy adults aged 20–30 years before and after massage, and also in control subjects. Three massage methods were used: applying periocular acupressure (“Chinese eye exercise”: CE), using a facial massage roller (MR), and using an automated eye massager (AM). The OBF and visual acuity were first measured before and after applying each type of massage for 5 min. Eye massage was then applied for 5 min once daily over a 60-day period, while the control group received no massage. The same measurements were then performed again. Results: Performing short-term periocular massage showed significant interactions in time and massage effects on visual acuity in CE and AM groups, and on OBF in AM group, while 60-day massage period exerted no significant effects. No significant relationship was found between OBF and visual acuity changes. Conclusions: These results suggest that short-term periocular massage with Chinese eye exercise and automated eye massager can improve OBF and visual acuity, although no causal relationship was supported.

scholarly journals PATHOMORPHOLOGICAL CHANGES IN RATS' RETINAL LAYERS AT THE END OF THE TWELFTH WEEK OF EXPERIMENTAL OPIOID INFLUENCE

2019 ◽  
pp. 19-21 ◽  
Author(s):  
Paltov E. V. ◽  
Kovalyshyn O. A. ◽  
Fik V. B. ◽  
Kryvko Y. Ya. ◽  
Podoliuk M. V. ◽  
...  
Keyword(s):  
Blood Flow ◽  
Pigment Epithelium ◽  
Opioid Analgesics ◽  
Optimal Timing ◽  
Long Term Effects ◽  
Microcirculatory Blood Flow ◽  
Retinal Layers ◽  
Therapeutic Doses

The goal in our work was to study the long-term effects of opioid analgesics in therapeutic doses on the structure of the retinal layers in chronic opioid influence. The goal was achieved by using the microscopic technique of visualizing the retinal layers of the eyeball of the rat. Microstructural preparations were prepared according to the generally accepted method using dyes, hematoxylin, eosin, and azan by the method of Heidenhain.As a result of the twelve-week experimental opioid effect, we discovered vacuated dystrophy and necrotic changes in the pigment epithelium, with the progression of the phenomenon of microcystoid degeneration of the outer mesh layer, and the increase in changes in the microcirculatory blood flow localized in the inner layers of the retina.The results of our experimental research in the future will allow us to form a pathomorphological basis, which can be used to perform a comparative characterization of the state of the layers of the retina and its the microcirculatory blood flow in normal range with experimental opioid effects at different terms of acute, subchronic and chronic opioid effects. Using the above information, we will be able to determine the optimal timing for correction in order to reduce and stabilize the pathomorphological manifestations of opioid effects on destructive changes in the layers of the retina and its the microcirculatory blood flow.

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