Isoflurane blocks glutamatergic excitatory transmission pre- and postsynaptically in crayfish muscle

1998 ◽  
Vol 183 (2) ◽  
pp. 237-246 ◽  
Author(s):  
M. Schramm ◽  
J. Dudel
Keyword(s):  
Crayfish Muscle ◽  
Excitatory Transmission

scholarly journals Ketamine Produces a Long-Lasting Enhancement of CA1 Neuron Excitability

2021 ◽  
Vol 22 (15) ◽  
pp. 8091
Author(s):  
Grace Jang ◽  
M. Bruce MacIver
Keyword(s):  
Nmda Receptor ◽  
Potassium Channel ◽  
Receptor Antagonist ◽  
Hippocampal Slices ◽  
Nmda Receptor Antagonist ◽  
Channel Block ◽  
Mk 801 ◽  
Ca1 Region ◽  
Excitatory Transmission ◽  
Ketamine Anesthesia

Ketamine is a clinical anesthetic and antidepressant. Although ketamine is a known NMDA receptor antagonist, the mechanisms contributing to antidepression are unclear. This present study examined the loci and duration of ketamine’s actions, and the involvement of NMDA receptors. Local field potentials were recorded from the CA1 region of mouse hippocampal slices. Ketamine was tested at antidepressant and anesthetic concentrations. Effects of NMDA receptor antagonists APV and MK-801, GABA receptor antagonist bicuculline, and a potassium channel blocker TEA were also studied. Ketamine decreased population spike amplitudes during application, but a long-lasting increase in amplitudes was seen during washout. Bicuculline reversed the acute effects of ketamine, but the washout increase was not altered. This long-term increase was statistically significant, sustained for >2 h, and involved postsynaptic mechanisms. A similar effect was produced by MK-801, but was only partially evident with APV, demonstrating the importance of the NMDA receptor ion channel block. TEA also produced a lasting excitability increase, indicating a possible involvement of potassium channel block. This is this first report of a long-lasting increase in excitability following ketamine exposure. These results support a growing literature that increased GABA inhibition contributes to ketamine anesthesia, while increased excitatory transmission contributes to its antidepressant effects.

scholarly journals The Endogenous Stress Hormone CRH Modulates Excitatory Transmission and Network Physiology in Hippocampus

2017 ◽  
Vol 27 (8) ◽  
pp. 4182-4198 ◽  
Author(s):  
B. G. Gunn ◽  
C. D. Cox ◽  
Y. Chen ◽  
M. Frotscher ◽  
C. M. Gall ◽  
...  
Keyword(s):  
Stress Hormone ◽  
Excitatory Transmission

Single synaptic channels recorded at glutamate sensitive patches on a crayfish muscle

1983 ◽  
Vol 42 (1) ◽  
pp. 7-12 ◽  
Author(s):  
C. Franke ◽  
J. Dudel ◽  
W. Finger
Keyword(s):  
Crayfish Muscle

scholarly journals Excitatory transmission at thalamo-striatal synapses mediates susceptibility to social stress

2015 ◽  
Vol 18 (7) ◽  
pp. 962-964 ◽  
Author(s):  
Daniel J Christoffel ◽  
Sam A Golden ◽  
Jessica J Walsh ◽  
Kevin G Guise ◽  
Mitra Heshmati ◽  
...  
Keyword(s):  
Social Stress ◽  
Excitatory Transmission

Effect of hypoxia on excitatory transmission in the rat substantia gelatinosa neurons

2002 ◽  
Vol 295 (4) ◽  
pp. 929-936 ◽  
Author(s):  
Yun Kyung Park ◽  
Sung Jun Jung ◽  
Jiyeon Kwak ◽  
Jun Kim
Keyword(s):  
Substantia Gelatinosa ◽  
Excitatory Transmission
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