Differential regulation of a homologous peptidergic neuron in grasshoppers: evolution of a neural circuit

1998 ◽  
Vol 182 (6) ◽  
pp. 755-765 ◽  
Author(s):  
C. T. Lundquist ◽  
R. A. Baines ◽  
K. S. J. Thompson ◽  
J. P. Bacon
Keyword(s):  
Neural Circuit ◽  
Differential Regulation ◽  
Peptidergic Neuron

scholarly journals Neuroendocrine Modulation Sustains the C. elegans Forward Motor State

2016 ◽  
Author(s):  
Maria A. Lim ◽  
Jyothsna Chitturi ◽  
Valeriya Laskova ◽  
Jun Meng ◽  
Daniel Findeis ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Calcium Imaging ◽  
Neural Circuit ◽  
Transcriptome Profiling ◽  
Behavioral State ◽  
Forward Movement ◽  
C Elegans ◽  
Peptidergic Neuron ◽  
Homeobox Transcription Factor

AbstractNeuromodulators shape neural circuit dynamics. Combining electron microscopy, genetics, transcriptome profiling, calcium imaging, and optogenetics, we discovered a peptidergic neuron that modulates C. elegans motor circuit dynamics. The Six/SO-family homeobox transcription factor UNC-39 governs lineage-specific neurogenesis to give rise to a neuron RID. RID bears the anatomic hallmarks of a specialized endocrine neuron: it harbors near-exclusive dense core vesicles that cluster periodically along the axon, and expresses multiple neuropeptides, including the FMRF-amide-related FLP-14. RID activity increases during forward movement. Ablating RID reduces the sustainability of forward movement, a phenotype partially recapitulated by removing FLP-14. Optogenetic depolarization of RID prolongs forward movement, an effect reduced in the absence of FLP-14. Together, these results establish the role of a neuroendocrine cell RID in sustaining a specific behavioral state in C. elegans.

scholarly journals Neuroendocrine modulation sustains the C. elegans forward motor state

eLife ◽  
2016 ◽  
Vol 5 ◽  
Author(s):  
Maria A Lim ◽  
Jyothsna Chitturi ◽  
Valeriya Laskova ◽  
Jun Meng ◽  
Daniel Findeis ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Calcium Imaging ◽  
Neural Circuit ◽  
Transcriptome Profiling ◽  
Behavioral State ◽  
Forward Movement ◽  
C Elegans ◽  
Peptidergic Neuron ◽  
Homeobox Transcription Factor

Neuromodulators shape neural circuit dynamics. Combining electron microscopy, genetics, transcriptome profiling, calcium imaging, and optogenetics, we discovered a peptidergic neuron that modulates C. elegans motor circuit dynamics. The Six/SO-family homeobox transcription factor UNC-39 governs lineage-specific neurogenesis to give rise to a neuron RID. RID bears the anatomic hallmarks of a specialized endocrine neuron: it harbors near-exclusive dense core vesicles that cluster periodically along the axon, and expresses multiple neuropeptides, including the FMRF-amide-related FLP-14. RID activity increases during forward movement. Ablating RID reduces the sustainability of forward movement, a phenotype partially recapitulated by removing FLP-14. Optogenetic depolarization of RID prolongs forward movement, an effect reduced in the absence of FLP-14. Together, these results establish the role of a neuroendocrine cell RID in sustaining a specific behavioral state in C. elegans.

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