A QTL with major effect on milk yield and composition maps to bovine Chromosome 14

1998 ◽  
Vol 9 (7) ◽  
pp. 540-544 ◽  
Author(s):  
Wouter Coppieters ◽  
Juliette Riquet ◽  
Juan-José Arranz ◽  
Paulette Berzi ◽  
Nadine Cambisano ◽  
...  
Keyword(s):  
Milk Yield ◽  
Major Effect ◽  
Bovine Chromosome ◽  
Chromosome 14

scholarly journals Simultaneous Mining of Linkage and Linkage Disequilibrium to Fine Map Quantitative Trait Loci in Outbred Half-Sib Pedigrees: Revisiting the Location of a Quantitative Trait Locus With Major Effect on Milk Production on Bovine Chromosome 14

Genetics ◽  
2002 ◽  
Vol 161 (1) ◽  
pp. 275-287 ◽  
Author(s):  
Frédéric Farnir ◽  
Bernard Grisart ◽  
Wouter Coppieters ◽  
Juliette Riquet ◽  
Paulette Berzi ◽  
...  
Keyword(s):  
Linkage Disequilibrium ◽  
Quantitative Trait ◽  
Milk Fat ◽  
Haplotype Analysis ◽  
Major Effect ◽  
Mapping Method ◽  
Substitution Effects ◽  
Marker Interval ◽  
Chromosome 14 ◽  
Trait Locus

Abstract A maximum-likelihood QTL mapping method that simultaneously exploits linkage and linkage disequilibrium and that is applicable in outbred half-sib pedigrees is described. The method is applied to fine map a QTL with major effect on milk fat content in a 3-cM marker interval on proximal BTA14. This proximal location is confirmed by applying a haplotype-based association method referred to as recombinant ancestral haplotype analysis. The origin of the discrepancy between the QTL position derived in this work and that of a previous analysis is examined and shown to be due to the existence of distinct marker haplotypes associated with QTL alleles having large substitution effects.

scholarly journals Genome Assembly Anchored QTL Map of Bovine Chromosome 14

2008 ◽  
pp. 406-414 ◽  
Author(s):  
Tito A. Wibowo ◽  
Charles T. Gaskins ◽  
Ruth C. Newberry ◽  
Gary H. Thorgaard ◽  
Jennifer J. Michal ◽  
...  
Keyword(s):  
Genome Assembly ◽  
Bovine Chromosome ◽  
Chromosome 14 ◽  
Qtl Map

scholarly journals The BovMAS Consortium: identification of QTL for milk yield and milk protein percent on chromosome 14 in the Brown Swiss breed

2005 ◽  
Vol 4 (sup2) ◽  
pp. 13-15 ◽  
Author(s):  
A. Bagnato ◽  
F. Schiavini ◽  
M. Dolezal ◽  
S. Dubini ◽  
A. Rossoni ◽  
...  
Keyword(s):  
Milk Yield ◽  
Milk Protein ◽  
Chromosome 14 ◽  
Brown Swiss

A QTL affecting milk yield and composition maps to bovine chromosome 20: a confirmation

1998 ◽  
Vol 29 (2) ◽  
pp. 107-115 ◽  
Author(s):  
J.-J. Arranz ◽  
W. Coppieters ◽  
P. Berzi ◽  
N. Cambisano ◽  
B. Grisart ◽  
...  
Keyword(s):  
Milk Yield ◽  
Bovine Chromosome ◽  
Chromosome 20

Molecular Dissection of a Quantitative Trait Locus: A Phenylalanine-to-Tyrosine Substitution in the Transmembrane Domain of the Bovine Growth Hormone Receptor Is Associated With a Major Effect on Milk Yield and Composition

Genetics ◽  
2003 ◽  
Vol 163 (1) ◽  
pp. 253-266 ◽  
Author(s):  
Sarah Blott ◽  
Jong-Joo Kim ◽  
Sirja Moisio ◽  
Anne Schmidt-Küntzel ◽  
Anne Cornet ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Milk Yield ◽  
Hormone Receptor ◽  
Growth Hormone Receptor ◽  
Transmembrane Domain ◽  
Receptor Gene ◽  
Major Effect ◽  
Chromosome 20 ◽  
Growth Hormone Receptor Gene ◽  
Trait Locus

Abstract We herein report on our efforts to improve the mapping resolution of a QTL with major effect on milk yield and composition that was previously mapped to bovine chromosome 20. By using a denser chromosome 20 marker map and by exploiting linkage disequilibrium using two distinct approaches, we provide strong evidence that a chromosome segment including the gene coding for the growth hormone receptor accounts for at least part of the chromosome 20 QTL effect. By sequencing individuals with known QTL genotype, we identify an F to Y substitution in the transmembrane domain of the growth hormone receptor gene that is associated with a strong effect on milk yield and composition in the general population.

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