The gene encoding the multispecific organic anion transporter (Cmoat) of the hepatocyte canalicular membrane maps to mouse Chromosome 19

1998 ◽  
Vol 9 (1) ◽  
pp. 87-88 ◽  
Author(s):  
Frank Lammert ◽  
David E. Cohen ◽  
Beverly Paigen ◽  
Martin C. Carey ◽  
David R. Beier
Keyword(s):  
Mouse Chromosome ◽  
Organic Anion ◽  
Organic Anion Transporter ◽  
Chromosome 19 ◽  
Gene Encoding ◽  
Canalicular Membrane ◽  
Anion Transporter

Hepatobiliary transport mechanism for the cyclopentapeptide endothelin antagonist BQ-123

1997 ◽  
Vol 272 (5) ◽  
pp. G979-G986
Author(s):  
H. C. Shin ◽  
Y. Kato ◽  
T. Yamada ◽  
K. Niinuma ◽  
A. Hisaka ◽  
...  
Keyword(s):  
Biliary Excretion ◽  
Organic Anion ◽  
Membrane Vesicles ◽  
Organic Anion Transporter ◽  
Canalicular Membrane ◽  
Hepatobiliary Transport ◽  
Anion Transporter ◽  
Eisai Hyperbilirubinemic Rats ◽  
Endothelin Antagonist

The hepatobiliary transport of an anionic cyclopentapeptide endothelin antagonist, BQ-123, was studied in rats. Biliary excretion of [3H]BQ-123 was extensive in vivo (approximately 75% of intravenous infusion rates). Liver-to-plasma and bile-to-liver concentration ratios at steady state were approximately 3 and 200, respectively, suggesting that hepatic uptake and biliary excretion are concentrative processes. The biliary excretion clearance exhibited a saturation at a hepatic concentration of > 100 nmol/g liver and was markedly reduced in Eisai hyperbilirubinemic rats, which have a hereditary defect of canalicular multispecific organic anion transporter. An ATP-dependent and saturable uptake of BQ-123 by isolated canalicular membrane vesicles was observed in vitro. Impaired transport of BQ-123 was also confirmed in canalicular membrane vesicles prepared from Eisai hyperbilirubinemic rats. These results demonstrate that the biliary excretion process is ATP-driven primary active transport. It is proposed that a canalicular multispecific organic anion transporter is mainly responsible for the biliary excretion of BQ-123.

Effect of SLCO1B1 gene polymorphisms and vitamin D on statin-induced myopathy

2018 ◽  
Vol 33 (1) ◽  
pp. 41-47 ◽  
Author(s):  
Baraa Alghalyini ◽  
Said El Shamieh ◽  
Ali Salami ◽  
Sophie Visvikis Siest ◽  
Hana M. Fakhoury ◽  
...  
Keyword(s):  
Vitamin D ◽  
Organic Anion ◽  
Substantial Reduction ◽  
Cardiovascular Complications ◽  
Organic Anion Transporter ◽  
Gene Encoding ◽  
Transporter Protein ◽  
Cholesterol Levels ◽  
Hybridization Probes ◽  
Anion Transporter

Abstract Background Statin therapy used to lower cholesterol levels results in a substantial reduction in cardiovascular complications. Previous observations in different ethnic populations showed that rs2306283A>G, p.Asn130Asp and rs4149056T>C, p.Val174Ala in solute carrier organic anion transporter 1B1 (SLCO1B1) gene encoding the organic transporter protein may be responsible for statin uptake, thus explaining the majority of statin-associated symptoms. In addition to the genetic component, vitamin D (vit D) deficiency is common in Saudi Arabia and worldwide and may cause muscle dysfunction and ache. The aim of the present study was first to reveal an effect of vit D, rs2306283A>G, and rs4149056T>C and related haplotypes on statin-associated myopathy (SAM) and then to investigate a possible interaction between low vit D levels and the above-mentioned variants. Methods The genomic DNA obtained from 50 individuals diagnosed with hypercholesterolemia was genotyped using light SNiP hybridization probes. Results Low vit D levels were associated with SAM (OR=3.6, p=0.03); however, CK levels, rs2306283A>G, and rs4149056T>C did not show any association. Interestingly, rs4149056T>C was interacting with vit D to influence SAM (p=0.02). Haplotype analysis showed that SLCO1B1 *1B and *15 were more prevalent in individuals with SAM (p=0.05). When stratified according to vit D levels, rs2306283A allele showed an increase in individuals having SAM along with low vit D (p=0.03). Conclusions Although preliminary, our results show an involvement of vit D and rs4149056T>C of SLCO1B1 in SAM.

Characterization of hepatobiliary organic anion transporter regulation in the Zucker rat

2004 ◽  
Vol 42 (08) ◽  
Author(s):  
A Geier ◽  
CG Dietrich ◽  
C Gartung ◽  
F Lammert ◽  
HE Wasmuth ◽  
...  
Keyword(s):  
Organic Anion ◽  
Organic Anion Transporter ◽  
Zucker Rat ◽  
Anion Transporter
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