Chromosomal localization of acquired MMTV proviral integration sites in T-cell lymphomas

1998 ◽  
Vol 9 (1) ◽  
pp. 84-85 ◽  
Author(s):  
Lakshmi Rajan ◽  
Christine A. Kozak ◽  
Jaquelin P. Dudley
Keyword(s):  
T Cell ◽  
Chromosomal Localization ◽  
Proviral Integration ◽  
T Cell Lymphomas ◽  
Integration Sites

scholarly journals Sint1, a Common Integration Site in SL3-3-Induced T-Cell Lymphomas, Harbors a Putative Proto-Oncogene with Homology to the Septin Gene Family

2000 ◽  
Vol 74 (5) ◽  
pp. 2161-2168 ◽  
Author(s):  
Annette Balle Sørensen ◽  
Anders H. Lund ◽  
Steen Ethelberg ◽  
Neal G. Copeland ◽  
Nancy A. Jenkins ◽  
...  
Keyword(s):  
T Cell ◽  
Cdna Clone ◽  
Integration Site ◽  
Fusion Partner ◽  
Newborn Mice ◽  
Potent Inducer ◽  
T Cell Lymphomas ◽  
Integration Sites ◽  
Virus Integration ◽  
Provirus Integration

ABSTRACT The murine retrovirus SL3-3 is a potent inducer of T-cell lymphomas when inoculated into susceptible newborn mice. Previously, DNAs from twenty SL3-3-induced tumors were screened by PCR for provirus integration sites. Two out of 20 tumors demonstrated clonal provirus insertion into a common region. This region has now been isolated and characterized. The region, named SL3-3 integration site 1 (Sint1), maps to the distal end of mouse chromosome 11, corresponding to human chromosome 17q25, and may be identical to a mouse mammary tumor virus integration site in a T-cell lymphoma,Pad3. Two overlapping genomic λ clones spanning about 35 kb were isolated and used as a starting point for a search for genes in the neighborhood of the virus integration sites. A genomic fragment was used as a hybridization probe to isolate a 3-kb cDNA clone, the expression of which was upregulated in one of two tumors harboring a provirus in Sint1. The cDNA clone is predicted to encode a protein which shows 97.0% identity to a human septin-like protein encoded by a gene which has been found as a fusion partner gene of MLL in an acute myeloid leukemia with a t(11;17)(q23;q25). Together these findings raise the possibility that a proto-oncogene belonging to the septin family, and located about 15 kb upstream of the provirus integration sites, is involved in murine leukemia virus-induced T-cell lymphomagenesis.

Herpes zoster-varicella in cutaneous T-cell lymphomas

1980 ◽  
Vol 116 (4) ◽  
pp. 408-412 ◽  
Author(s):  
E. C. Vonderheid
Keyword(s):  
Herpes Zoster ◽  
T Cell ◽  
T Cell Lymphomas

Treatment of Cutaneous T-Cell Lymphomas

2000 ◽  
Vol 19 (2) ◽  
pp. 142-148 ◽  
Author(s):  
J Marcus Muche ◽  
Sylke Gellrich ◽  
Wolfram Sterry
Keyword(s):  
T Cell ◽  
T Cell Lymphomas

Tumor progression in murine leukemia virus-induced T-cell lymphomas: monitoring clonal selections with viral and cellular probes.

1986 ◽  
Vol 60 (1) ◽  
pp. 230-241 ◽  
Author(s):  
H T Cuypers ◽  
G C Selten ◽  
M Zijlstra ◽  
R E de Goede ◽  
C J Melief ◽  
...  
Keyword(s):  
T Cell ◽  
Tumor Progression ◽  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
T Cell Lymphomas ◽  
Cellular Probes ◽  
Murine Leukemia
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