Genetic mapping of the IL-12 alpha chain gene (1112a) on mouse Chromosome 3

1996 ◽  
Vol 7 (5) ◽  
pp. 394-395 ◽  
Author(s):  
P. A. Schweitzer ◽  
N. Noben-Trauth ◽  
S. C. Pelsue ◽  
K. R. Johnson ◽  
S. F. Wolf ◽  
...  
Keyword(s):  
Genetic Mapping ◽  
Mouse Chromosome ◽  
Chromosome 3 ◽  
Chain Gene ◽  
Alpha Chain

Genetic mapping of the voltage-gated shaker potassium channel beta subunit Kcnab1 to mouse Chromosome 3

1998 ◽  
Vol 9 (3) ◽  
pp. 260-260 ◽  
Author(s):  
J. M. Jones ◽  
E. Bentley ◽  
M. H. Meisler ◽  
Susan M. Darling
Keyword(s):  
Genetic Mapping ◽  
Potassium Channel ◽  
Mouse Chromosome ◽  
Beta Subunit ◽  
Chromosome 3 ◽  
Shaker Potassium Channel ◽  
Voltage Gated

scholarly journals Structure, expression, and genetic linkage of the mouse BCM1 (OX45 or Blast-1) antigen. Evidence for genetic duplication giving rise to the BCM1 region on mouse chromosome 1 and the CD2/LFA3 region on mouse chromosome 3.

1990 ◽  
Vol 171 (6) ◽  
pp. 2115-2130 ◽  
Author(s):  
Y W Wong ◽  
A F Williams ◽  
S F Kingsmore ◽  
M F Seldin
Keyword(s):  
Human Chromosome ◽  
Mouse Chromosome ◽  
Genetic Linkage ◽  
Field Analysis ◽  
Chromosome 1 ◽  
Pulse Field ◽  
Chromosome 3 ◽  
Chain Gene ◽  
Chromosome 1Q ◽  
Mouse Chromosome 1

The mouse BCM1 (OX45, Blast-1) antigen has been cDNA cloned and sequenced to provide data supporting the view that BCM1, LFA3, and CD2 constitute a subgroup within the Ig superfamily. Mouse BCM1 is widely expressed on leukocytes and is likely to be anchored to the cell surface by a glycosyl-phosphatidylinositol anchor, as is the case for rat and human BCM1 antigen. Genetic linkage studies by recombination and pulse field analysis showed the BCM1 locus (Bcm-1) to be on distal mouse chromosome 1 and to be linked within 1,600 kb to the locus for an ATPase alpha chain gene (Atpa-3). A similar relationship was established between the human BCM1 locus (BCM1) and ATP1A2, and other markers on chromosome 1q. Conservation of genomic organization within a segment of human chromosome 1q and mouse chromosome 1 was demonstrated. A similar situation is seen in the region of the CD2 and LFA3 genes between mouse chromosome 3 and human chromosome 1p. Furthermore, the CD2/LFA3 genes are linked within 580 kb to Atpa-1/ATP1A1 genes to provide a parallel situation to the linkage between Bcm-1/BCM1 and Atpa-3/ATP1A2 on chromosomes 1 (mouse) and 1q (human). Taken together, the data suggest duplication of a chromosome region including the precursors of the genes for BCM1, CD2, and LFA3, and the ATPase genes to give rise to the linkage groups now observed. The duplicated regions may have stayed together on chromosome 1 in the human (with the insertion of a centromere), while in the mouse, the genetic regions are proposed to have become dispersed in the formation of chromosomes 1 and 3. CD2 and LFA3 are more dissimilar in sequence than BCM1 and LFA3, and if the precursors of the CD2 and LFA3 loci formed before the proposed chromosome segment duplication, then a gene encoding a recognizer molecule for BCM1 may exist in linkage with Bcm-1/BCM1 on chromosome 1 (mouse) and 1q (human).

Genetic Mapping of a Gene Encoding an Atypical Protein Kinase C, Protein Kinase C Lambda, to the Proximal Region of Mouse Chromosome 3

Genomics ◽  
1995 ◽  
Vol 29 (3) ◽  
pp. 815-816
Author(s):  
Nandita A. Quaderi ◽  
Fernando Gianfrancesco ◽  
Steve D.M. Brown ◽  
Michele D'Urso ◽  
Maurizio D'Esposito
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Genetic Mapping ◽  
Mouse Chromosome ◽  
Proximal Region ◽  
Chromosome 3 ◽  
Gene Encoding ◽  
C Protein ◽  
Atypical Protein Kinase ◽  
Kinase C

Genetic mapping of vacuolar protein sorting-45 (Vps45) on mouse Chromosome 3

1998 ◽  
Vol 9 (1) ◽  
pp. 90-91 ◽  
Author(s):  
Vishnu S. Mishra ◽  
Sandra M. Holt ◽  
Juan M. Teodoro ◽  
Stephen F. Kingsmore
Keyword(s):  
Genetic Mapping ◽  
Mouse Chromosome ◽  
Protein Sorting ◽  
Chromosome 3 ◽  
Vacuolar Protein Sorting ◽  
Vacuolar Protein

Genetic mapping of the tumor-associated mucin 1 gene on mouse Chromosome 3

1995 ◽  
Vol 6 (5) ◽  
pp. 378-379
Author(s):  
S. F. Kingsmore ◽  
A. P. Spicer ◽  
S. J. Gendler ◽  
M. F. Seldin
Keyword(s):  
Genetic Mapping ◽  
Mouse Chromosome ◽  
Chromosome 3 ◽  
Mucin 1

Sequence variants in the FcεRI alpha chain gene

2002 ◽  
Vol 93 (1) ◽  
pp. 37-41 ◽  
Author(s):  
Toshiki Shikanai ◽  
Eric S. Silverman ◽  
Brian W. Morse ◽  
Craig M. Lilly ◽  
Hiroshi Inoue ◽  
...  
Keyword(s):  
Promoter Region ◽  
Population Substructure ◽  
Chain Gene ◽  
Polymorphism Analysis ◽  
Sequence Variants ◽  
Nucleotide Polymorphisms ◽  
Coding Region ◽  
Alpha Chain ◽  
Asthmatic Patients ◽  
Single Stranded Conformational Polymorphism

There is a relationship between IgE levels and expression of high-affinity IgE receptors (FcεRI). Because the alpha chain is the only portion of the receptor that binds directly to IgE, we reasoned that sequence variants in the FcεRI alpha gene may exist that alter these binding events. We screened all of the exons and the promoter region of the FcεRI alpha chain gene with genomic DNA from 389 asthmatic and 341 normal control subjects for mutations by using single-stranded conformational polymorphism analysis. No nonsynonomous single nucleotide polymorphisms (SNPs) were identified in the coding region. Three SNPs were found in the promoter region: an A/C transversion at −770 from the translation start site; a G/A transition at −664; and a T/C transition at −335. No differences in allele frequencies were detected between asthmatic subjects and controls. Homozygosity for the C variant at locus −335 was more common in Caucasian asthmatic patients with IgE levels in the lower quartile than in the upper quartile ( P = 0.032). An analysis of highly polymorphic SNPs indicated that this association is unlikely to be due to population substructure. We conclude that homozygosity for the C allele of FcεRI alpha chain variant is associated with lower IgE levels.

Identification and Genetic Mapping of a New Polycystic Kidney Disease on Mouse Chromosome 8

Genomics ◽  
1997 ◽  
Vol 40 (1) ◽  
pp. 101-107 ◽  
Author(s):  
Poornima M. Janaswami ◽  
Edward H. Birkenmeier ◽  
Susan A. Cook ◽  
Lucy B. Rowe ◽  
Roderick T. Bronson ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Genetic Mapping ◽  
Polycystic Kidney Disease ◽  
Mouse Chromosome ◽  
Chromosome 8 ◽  
Polycystic Kidney ◽  
Mouse Chromosome 8

scholarly journals A frameshift mutation in Exon V of the A alpha-chain gene leading to truncated A alpha-chains in the homozygous dysfibrinogen Milano III

1994 ◽  
Vol 269 (52) ◽  
pp. 33129-33134
Author(s):  
M Furlan ◽  
C Steinmann ◽  
M Jungo ◽  
C Bögli ◽  
F Baudo ◽  
...  
Keyword(s):  
Frameshift Mutation ◽  
Chain Gene ◽  
Alpha Chain
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