The murine type 1 diabetes loci, Idd1, Idd3, Idd5, Idd9, and Idd17/10/18, do not control thymic CD4 − CD8 − /TCRαβ + deficiency in the nonobese diabetic mouse

2001 ◽  
Vol 12 (2) ◽  
pp. 175-176 ◽  
Author(s):  
Christopher J. Lord ◽  
Sarah Howlett ◽  
Paul A. Lyons ◽  
Laurence B. Peterson ◽  
Linda S. Wicker ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Diabetic Mouse ◽  
Nonobese Diabetic Mouse ◽  
Nonobese Diabetic

scholarly journals Genetic Interactions among Idd3, Idd5.1, Idd5.2, and Idd5.3 Protective Loci in the Nonobese Diabetic Mouse Model of Type 1 Diabetes

2013 ◽  
Vol 190 (7) ◽  
pp. 3109-3120 ◽  
Author(s):  
Xiaotian Lin ◽  
Emma E. Hamilton-Williams ◽  
Daniel B. Rainbow ◽  
Kara M. Hunter ◽  
Yang D. Dai ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Mouse Model ◽  
Diabetic Mouse ◽  
Genetic Interactions ◽  
Nonobese Diabetic Mouse ◽  
Nonobese Diabetic

Prominently decreased hippocampal neurogenesis in a spontaneous model of type 1 diabetes, the nonobese diabetic mouse

2008 ◽  
Vol 210 (2) ◽  
pp. 359-367 ◽  
Author(s):  
J. Beauquis ◽  
F. Saravia ◽  
J. Coulaud ◽  
P. Roig ◽  
M. Dardenne ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Diabetic Mouse ◽  
Hippocampal Neurogenesis ◽  
Nonobese Diabetic Mouse ◽  
Nonobese Diabetic

scholarly journals Islet  -Cell Endoplasmic Reticulum Stress Precedes the Onset of Type 1 Diabetes in the Nonobese Diabetic Mouse Model

Diabetes ◽  
2012 ◽  
Vol 61 (4) ◽  
pp. 818-827 ◽  
Author(s):  
S. A. Tersey ◽  
Y. Nishiki ◽  
A. T. Templin ◽  
S. M. Cabrera ◽  
N. D. Stull ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Type 1 Diabetes ◽  
Endoplasmic Reticulum Stress ◽  
Mouse Model ◽  
Islet Cell ◽  
Diabetic Mouse ◽  
Nonobese Diabetic Mouse ◽  
Nonobese Diabetic

scholarly journals 2431

2017 ◽  
Vol 1 (S1) ◽  
pp. 37-37
Author(s):  
Andrea Lin ◽  
Clayton Mathews ◽  
Michael Haller ◽  
Todd Brusko ◽  
Mark Atkinson ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Type 1 Diabetes ◽  
T Regulatory Cells ◽  
Immune Cell ◽  
Diabetic Mouse ◽  
Regulatory Cells ◽  
Flow Cytometry Analysis ◽  
Nonobese Diabetic Mouse ◽  
Nonobese Diabetic

OBJECTIVES/SPECIFIC AIMS: Understand the immunomodulatory effects of anti-thymocyte globulin (ATG) and granulocyte colony stimulating factor (G-CSF) on type 1 diabetes patients using samples and in the preclinical model, the nonobese diabetic mouse. METHODS/STUDY POPULATION: Flow cytometry analysis of phase 1 peripheral blood samples treatment of nonobese diabetic mouse with ATG and GCSF and flow cytometry analysis of immune organs (spleen, lymph nodes, blood, bone marrow). RESULTS/ANTICIPATED RESULTS: Changes in both innate and adaptive immune cell subsets including plasmacytoid dendritic cells, naive, memory, effector CD4+ and CD8+ T-cells, and CD4+ T-regulatory cells and CD8+ T-regulatory cells DISCUSSION/SIGNIFICANCE OF IMPACT: Understanding of immune cell targets for immunotherapy in new-onset type 1 diabetes patients.

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