The X Chromosome harbors quantitative trait loci for backfat thickness and intramuscular fat content in pigs

2000 ◽  
Vol 11 (9) ◽  
pp. 800-802 ◽  
Author(s):  
Barbara Harlizius ◽  
Annemieke P. Rattink ◽  
Dirk J. de Koning ◽  
Marilyne Faivre ◽  
Ruth G. Joosten ◽  
...  
Keyword(s):  
Quantitative Trait Loci ◽  
X Chromosome ◽  
Quantitative Trait ◽  
Intramuscular Fat ◽  
Fat Content ◽  
Backfat Thickness ◽  
Trait Loci ◽  
Intramuscular Fat Content

Porcine intramuscular fat content and composition are regulated by quantitative trait loci with muscle-specific effects1

2011 ◽  
Vol 89 (10) ◽  
pp. 2963-2971 ◽  
Author(s):  
R. Quintanilla ◽  
R. N. Pena ◽  
D. Gallardo ◽  
A. Cánovas ◽  
O. Ramírez ◽  
...  
Keyword(s):  
Quantitative Trait Loci ◽  
Quantitative Trait ◽  
Intramuscular Fat ◽  
Fat Content ◽  
Trait Loci ◽  
Intramuscular Fat Content

scholarly journals Exploring Alternative Models for Sex-Linked Quantitative Trait Loci in Outbred Populations: Application to an Iberian × Landrace Pig Intercross

Genetics ◽  
2002 ◽  
Vol 161 (4) ◽  
pp. 1625-1632
Author(s):  
Miguel Pérez-Enciso ◽  
Alex Clop ◽  
Josep M Folch ◽  
Armand Sánchez ◽  
Maria A Oliver ◽  
...  
Keyword(s):  
Quantitative Trait Loci ◽  
Quantitative Trait ◽  
Mixed Models ◽  
Intramuscular Fat ◽  
Limited Evidence ◽  
Color Component ◽  
Trait Loci ◽  
Outbred Populations ◽  
Landrace Pig ◽  
Intramuscular Fat Content

Abstract We present a very flexible method that allows us to analyze X-linked quantitative trait loci (QTL) in crosses between outbred lines. The dosage compensation phenomenon is modeled explicitly in an identity-by-descent approach. A variety of models can be fitted, ranging from considering alternative fixed alleles within the founder breeds to a model where the only genetic variation is within breeds, as well as mixed models. Different genetic variances within each founder breed can be estimated. We illustrate the method with data from an F2 cross between Iberian × Landrace pigs for intramuscular fat content and meat color component a*. The Iberian allele exhibited a strong overdominant effect for intramuscular fat in females. There was also limited evidence of one or more regions affecting color component a*. The analysis suggested that the QTL alleles were fixed in the Iberian founders, whereas there was some evidence of segregation in Landrace for the QTL affecting a* color component.

scholarly journals Association of Twelve Candidate Gene Polymorphisms with the Intramuscular Fat Content and Average Backfat Thickness of Chinese Suhuai Pigs

Animals ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 858 ◽  
Author(s):  
Wang ◽  
Li ◽  
Zhou ◽  
Gao ◽  
Liu ◽  
...  
Keyword(s):  
Molecular Markers ◽  
Gene Polymorphisms ◽  
Genetic Correlations ◽  
Intramuscular Fat ◽  
Fat Content ◽  
Backfat Thickness ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Coefficients Of Variation ◽  
Intramuscular Fat Content

The present study aimed to identify the molecular markers for genes that influence intramuscular fat content (IFC), but not average backfat thickness (ABT). A total of 330 Suhuai pigs were slaughtered, and measurements of IFC and ABT were obtained. Phenotypic and genetic correlations between IFC and ABT were calculated. Thirteen single nucleotide polymorphisms (SNPs) among 12 candidate genes for IFC were analyzed, including FABP3, LIPE, IGF1, IGF2, LEP, LEPR, MC4R, PHKG1, RETN, RYR1, SCD, and UBE3C. Associations of the evaluated SNPs with IFCIFC and ABT were performed. Our results showed that the means of IFC and ABT were 1.99 ± 0.03 % and 26.68 ± 0.28 mm, respectively. The coefficients of variation (CVs) of IFC and ABT were 31.21% and 19.36%, respectively. The phenotypic and genetic correlations between IFC and ABT were moderate. Only the FABP3 (rs1110770079) was associated with IFC (p < 0.05) but not with ABT. Besides, there was a tendency for associations of RYR1 (rs344435545) and SCD (rs80912566) with IFC (p < 0.1). Our results indicated that the FABP3 (rs1110770079) SNP could be used as a marker to improve IFC without changing ABT in the Suhuai pig breeding system.

scholarly journals Mapping quantitative trait loci for body weight on the X chromosome in mice. I. Analysis of a reciprocal F2 population

1997 ◽  
Vol 70 (2) ◽  
pp. 117-124 ◽  
Author(s):  
KELLIE A. RANCE ◽  
WILLIAM G. HILL ◽  
PETER D. KEIGHTLEY
Keyword(s):  
Body Weight ◽  
Quantitative Trait Loci ◽  
X Chromosome ◽  
Quantitative Trait ◽  
Selection Line ◽  
Fat Percentage ◽  
Analytical Technique ◽  
F2 Population ◽  
Trait Loci ◽  
Males And Females

Evidence of a large sex-linked effect accounting for 25% of the divergence between mouse lines selected for body weight has been described previously. A marker-based study was undertaken to determine the number and map positions of the putative X-linked quantitative trait loci (QTLs). An F2 population was generated from a reciprocal F1 between an inbred low line derived from the low selection line and the high selection line. To enable inference of marker-associated QTL effects on the X chromosome, an analytical technique was developed based on the multiple regression method of Haley and Knott. The analysis of data on 10 week weight indicated a single QTL of large effect situated at about 23 cM from the proximal end of the chromosome, with a peak LOD score of 24·4. The likelihood curve showed a single well-defined peak, and gave a 95% confidence interval for the QTL location of 8 cM. The estimates for the additive genotypic effects in males and females (half the differences between hemizygous males and between homozygous females) were 2·6 g in both cases, or 17% and 20% of the 10 week body weight in males and females respectively. Dominance effects in the females were found to be non-significant. No significant X-linked effect on carcass fat percentage was detected, but a single X-linked QTL appears to explain almost the entire X-linked body weight effect.

scholarly journals Haplotype analysis within quantitative trait locus affecting intramuscular fat content on porcine chromosome

2011 ◽  
Vol 56 (No. 12) ◽  
pp. 521-528
Author(s):  
S. Sato ◽  
C. Ohnishi ◽  
Y. Uemoto ◽  
E. Kobayashi
Keyword(s):  
Quantitative Trait ◽  
Haplotype Analysis ◽  
Intramuscular Fat ◽  
Fat Content ◽  
Porcine Chromosome ◽  
Large White ◽  
Positional Candidate ◽  
Synonymous Substitutions ◽  
Trait Locus ◽  
Intramuscular Fat Content

Previous results of fine mapping for quantitative trait loci affecting intramuscular fat content identified a 3.0-Mb chromosome interval on porcine chromosome 7, which contains at least 9 genes, based on the pig genome assembly. Therefore, we proposed these nine genes (LOC100154481, LOC100155711, LOC100155276, SPATA7, PTPN21, ZCH14, EML5, TTC8, and FOXN3) as positional candidate genes. The coding exons of the nine genes were characterized, and 45 polymorphisms were detected in F<sub>2</sub> Duroc &times; Meishan population. Within the nine genes, 10 non-synonymous substitutions and 1 insertion were genotyped among three European breeds (Landrace, Large White, and Duroc) and 1 Chinese breed (Meishan). Genotyping data was used to perform the haplotype analysis. Polymorphisms were found in all the studied genes, except ZCH14. We surveyed the frequency of 33 haplotypes that formed non-synonymous substitutions in four breeds. One of them was distributed widely in the Landrace, Large White, and Meishan breeds, but not in Duroc. Each breed had different major haplotypes. &nbsp;

Two Powerful Tests for Parent-of-Origin Effects at Quantitative Trait Loci on the X Chromosome

2018 ◽  
Vol 83 (5) ◽  
pp. 250-273
Author(s):  
Pui Yin Lau ◽  
Kar Fu Yeung ◽  
Ji-Yuan Zhou ◽  
Wing Kam Fung
Keyword(s):  
Quantitative Trait Loci ◽  
X Chromosome ◽  
Quantitative Trait ◽  
Trait Loci ◽  
Parent Of Origin ◽  
Origin Effects

scholarly journals Quantitative Trait Loci Affecting Liver Fat Content in Mice

2012 ◽  
Vol 2 (9) ◽  
pp. 1019-1025 ◽  
Author(s):  
Olga Minkina ◽  
James M. Cheverud ◽  
Gloria Fawcett ◽  
Clay F. Semenkovich ◽  
Jane P. Kenney-Hunt
Keyword(s):  
Quantitative Trait Loci ◽  
Quantitative Trait ◽  
Fat Content ◽  
Liver Fat ◽  
Liver Fat Content ◽  
Trait Loci
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