Potentiation of doxorubicin efficacy in hepatocellular carcinoma by the DNA repair inhibitor DT01 in preclinical models

2017 ◽  
Vol 27 (10) ◽  
pp. 4435-4444 ◽  
Author(s):  
Nirmitha I. Herath ◽  
Flavien Devun ◽  
Aurélie Herbette ◽  
Marie-Christine Lienafa ◽  
Philippe Chouteau ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Dna Repair ◽  
Preclinical Models ◽  
Dna Repair Inhibitor

SCCA-IgM in hepatocellular carcinoma patients treated with transarterial chemoembolization: gender-related differences

2020 ◽  
Vol 14 (10) ◽  
pp. 855-867
Author(s):  
Filippo Pelizzaro ◽  
Federica Soldà ◽  
Romilda Cardin ◽  
Angela Imondi ◽  
Anna Sartori ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Transarterial Chemoembolization ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Immunoglobulin M ◽  
Care Hospital ◽  
Squamous Cell Carcinoma Antigen ◽  
Preclinical Models ◽  
Relevant Variable ◽  
Gender Specific

Aim: Squamous cell carcinoma antigen immune complexed with immunoglobulin M (SCCA-IgM) is a useful but not completely satisfactory biomarker of hepatocellular carcinoma (HCC). Considering its gender-specific behavior in preclinical models, we investigated gender-related differences of SCCA-IgM as a prognostic marker in HCC. Patients & methods: Two hundred and eight prospectively recruited patients treated with transarterial chemoembolization in a single tertiary care hospital were retrospectively evaluated. Correlations between SCCA-IgM levels, clinical characteristics and survival were assessed according to gender. Results: When the disease was advanced, SCCA-IgM was higher in males and lower in females. Levels below 130 AU/ml predicted a significantly longer survival in males (p = 0.007) and a shorter survival in females (p = 0.01). Conclusion: In predicting the prognosis of HCC patients, the interpretation of SCCA-IgM should consider gender as a relevant variable.

Genetic polymorphisms in DNA repair genes and hepatocellular carcinoma risk

DNA Repair ◽  
2021 ◽  
pp. 103196
Author(s):  
Hossein Ghaderi-Zefrehi ◽  
Maryam Rezaei ◽  
Farzin Sadeghi ◽  
Mohammad Heiat
Keyword(s):  
Hepatocellular Carcinoma ◽  
Dna Repair ◽  
Genetic Polymorphisms ◽  
Dna Repair Genes ◽  
Repair Genes ◽  
Carcinoma Risk

scholarly journals MicroRNA-146a-5p enhances radiosensitivity in hepatocellular carcinoma through replication protein A3-induced activation of the DNA repair pathway

2019 ◽  
Vol 316 (3) ◽  
pp. C299-C311 ◽  
Author(s):  
Jing Luo ◽  
Zhong-Zhou Si ◽  
Ting Li ◽  
Jie-Qun Li ◽  
Zhong-Qiang Zhang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Proliferation ◽  
Dna Damage ◽  
Dna Repair ◽  
Dna Damage Repair ◽  
Replication Protein ◽  
Repair Pathway ◽  
Related Factors ◽  
Damage Repair ◽  
Hcc Cells

Hepatocellular carcinoma (HCC) is known for its high mortality rate worldwide. Based on intensive studies, microRNA (miRNA) expression functions in tumor suppression. Therefore, we aimed to evaluate the contribution of miR-146a-5p to radiosensitivity in HCC through the activation of the DNA damage repair pathway by binding to replication protein A3 (RPA3). First, the limma package of R was performed to differentially analyze HCC expression chip, and regulative miRNA of RPA3 was predicted. Expression of miR-146a-5p, RPA3, and DNA damage repair pathway-related factors in tissues and cells was determined. The effects of radiotherapy on the expression of miR-146a-5p and RPA3 as well as on cell radiosensitivity, proliferation, cell cycle, and apoptosis were also assessed. The results showed that there exists a close correlation between miR-146a and the radiotherapy effect on HCC progression through regulation of RPA3 and the DNA repair pathway. The positive rate of ATM, pCHK2, and Rad51 in HCC tissues was higher when compared with that of the paracancerous tissues. SMMC-7721 and HepG2 cell proliferation were significantly inhibited following 8 Gy 6Mv dose. MiR-146a-5p restrained the expression of RPA3 and promoted the expression of relative genes associated with the DNA repair pathway. In addition, miR-146a-5p overexpression suppresses cell proliferation and enhances radiosensitivity and cell apoptosis in HCC cells. In conclusion, the present study revealed that miR-146a-5p could lead to the restriction of proliferation and the promotion of radiosensitivity and apoptosis in HCC cells through activation of DNA repair pathway and inhibition of RPA3.

Colorectal Cancer Metastasis: The DNA Repair Inhibitor Dbait Increases Sensitivity to Hyperthermia and Improves Efficacy of Radiofrequency Ablation

Radiology ◽  
2014 ◽  
Vol 270 (3) ◽  
pp. 736-746 ◽  
Author(s):  
Flavien Devun ◽  
Julian Biau ◽  
Michel Huerre ◽  
Amélie Croset ◽  
Jian-Sheng Sun ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dna Repair ◽  
Radiofrequency Ablation ◽  
Cancer Metastasis ◽  
Colorectal Cancer Metastasis ◽  
Dna Repair Inhibitor

scholarly journals The DNA Repair Inhibitor Dbait Is Specific for Malignant Hematologic Cells in Blood

2017 ◽  
Vol 16 (12) ◽  
pp. 2817-2827 ◽  
Author(s):  
Sylvain Thierry ◽  
Wael Jdey ◽  
Solana Alculumbre ◽  
Vassili Soumelis ◽  
Patricia Noguiez-Hellin ◽  
...  
Keyword(s):  
Dna Repair ◽  
Dna Repair Inhibitor

A new prognostic strategy based on four DNA repair-associated lncRNAs for hepatocellular carcinoma

2021 ◽  
Vol 24 ◽  
Author(s):  
Hanyi Zeng ◽  
Chengdong Liu ◽  
Xiaohan Zhou ◽  
Li Liu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Dna Repair ◽  
Clinical Utility ◽  
Prognostic Model ◽  
Cox Regression ◽  
Reduction Process ◽  
Roc Curves ◽  
Clinical Impact ◽  
Functional Enrichment ◽  
Prognostic Signature

Background: Hepatocellular carcinoma (HCC) is a malignant tumour with poor prognosis. The effect of DNA repair on prognosis cannot be ignored; and long non-coding RNA (lncRNA) can regulate the DNA repair process. Objective: : To obtain DNA repair-associated lncRNA (DR-lncRNA) prognostic signature for improved ability to prediction of HCC prognosis. Methods: Our study used the Cancer Genome Atlas database. Gene set variation analysis was performed to differentiate high and low levels of DNA repair to identify DR-lncRNAs. By performing univariate Cox regression, LASSO regression, and multivariate Cox regression analyses, we finally obtained a DR-lncRNA prognostic signature and constructed a nomogram prognostic model. Time-dependent receiver operating characteristic (ROC) curves, calibration plots, decision curve analysis (DCA), and clinical impact curves were used to assess predictive ability and clinical utility. Differentially expressed genes (DEGs) functional enrichment analysis was performed to further explore the underlying mechanisms that influence HCC prognosis. Results: We obtained a DR-lncRNA prognostic signature—AP002478.1, AC116351.1, LINC02580, and LINC00861. The ROC curves and calibration plots showed good discrimination and calibration properties. Combining the DR-lncRNA prognostic signature and tumour stages, we established a nomogram prognostic model. DCA and clinical impact curves showed the clinical utility of the nomogram prognostic model. DEGs of high-risk and low-risk groups predicted by the DR-lncRNA prognostic were significantly associated with cell cycle and various metabolic pathways and biological processes such as the oxidation-reduction process and cell division. Conclusion: We identified a DR-lncRNA prognostic signature and constructed a nomogram prognostic model, which could be a beneficial prognostic strategy for HCC.

Development of a Hypoxic Radiosensitizer‐Prodrug Liposome Delivery DNA Repair Inhibitor Dbait Combination with Radiotherapy for Glioma Therapy

2017 ◽  
Vol 6 (12) ◽  
pp. 1601377 ◽  
Author(s):  
Hongmei Liu ◽  
Yifan Cai ◽  
Yafei Zhang ◽  
Yandong Xie ◽  
Hui Qiu ◽  
...  
Keyword(s):  
Dna Repair ◽  
Dna Repair Inhibitor
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