Various pathogenetic factors revolving around the central role of protein kinase C activation in the occurrence of cerebral vasospasm

1998 ◽  
Vol 8 (3) ◽  
pp. 176-187 ◽  
Author(s):  
Takao Asano ◽  
Tohru Matsui
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Cerebral Vasospasm ◽  
Kinase C ◽  
Protein Kinase C Activation

scholarly journals Mechanisms of Cardiac Hypertrophy and Injury. Possible Role of Protein Kinase C Activation.

1991 ◽  
Vol 55 (11) ◽  
pp. 1149-1157 ◽  
Author(s):  
ISSEI KOMURO ◽  
YOUICHI KATOH ◽  
EITETSU HOH ◽  
FUMIMARO TAKAKU ◽  
YOSHIO YAZAKI
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Cardiac Hypertrophy ◽  
Kinase C ◽  
Protein Kinase C Activation

Modification of Na+/H+ Exchanger in Human Platelets by 1,2-Dioctanoylglycerol, a Protein Kinase C Activator

1990 ◽  
Vol 64 (01) ◽  
pp. 165-171 ◽  
Author(s):  
Yukio Ozaki ◽  
Yuki Mastsumoto ◽  
Yutaka Yatomi ◽  
Masaaki Higashihara
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Rate Constant ◽  
Human Platelets ◽  
Kinase C ◽  
Km Value ◽  
The Difference ◽  
The One ◽  
Protein Kinase C Activation

SummaryProtein kinase C activation in human platelets has a modulatory role in maintaining intracellular pH (pHi), by adjusting pHi at a particular value (7.22). Changes in pHi induced by protein kinase C appeared to be dependent upon the difference between H+ efflux catalyzed by the Na+/H+ exchanger and H+ production. The pHi recovery after acid loading was significantly facilitated by protein kinase C activation. Analysis of the rate constant for pHi recovery suggested that the turnover rate or the apparent affinity of the Na+/H+ exchanger for H+ was increased. Protein kinase C also decreased the Km value of the Na+/H+ exchanger for extracellular Na+. Thus, it is suggested that the role of protein kinase C in platelet pHi regulation is dual, adjusting the pHi value at a certain setpoint on the one hand, and increasing the rate constant of the Na+/H+ exchanger on the other.

The role of protein kinase C activation in signal transmission by interleukin 2

1988 ◽  
Vol 154 (1) ◽  
pp. 187-193 ◽  
Author(s):  
Naofumi Mukaida ◽  
Hitoshi Yagisawa ◽  
Tadashi Kawai ◽  
Tadashi Kasahara
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Signal Transmission ◽  
Interleukin 2 ◽  
Kinase C ◽  
Protein Kinase C Activation
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