Mitochondrial DNA rearrangements associated with mF plasmid integration and plasmodial longevity in Physarum polycephalum

1998 ◽  
Vol 33 (3) ◽  
pp. 178-187 ◽  
Author(s):  
Catherine Curtis Nakagawa ◽  
Elsy Perez Jones ◽  
D. L. Miller
Keyword(s):  
Mitochondrial Dna ◽  
Physarum Polycephalum ◽  
Dna Rearrangements ◽  
Plasmid Integration

Spectrum of mitochondrial DNA rearrangements in the Pearson marrow-pancreas syndrome

1995 ◽  
Vol 4 (8) ◽  
pp. 1327-1330 ◽  
Author(s):  
Agnès Rötig ◽  
Thomas Bourgeron ◽  
Dominique Chretien ◽  
Pierre Rustin ◽  
Arnold Munnich
Keyword(s):  
Mitochondrial Dna ◽  
Dna Rearrangements

scholarly journals Marked increase in the number and variety of mitochondrial DNA rearrangements in aging human skeletal muscle

1995 ◽  
Vol 23 (20) ◽  
pp. 4122-4126 ◽  
Author(s):  
S. Melov ◽  
J. M. Shoffner ◽  
A. Kaufman ◽  
D. C. Wallace
Keyword(s):  
Skeletal Muscle ◽  
Mitochondrial Dna ◽  
Human Skeletal Muscle ◽  
Dna Rearrangements

scholarly journals Non-DNA-Templated Addition of Nucleotides to the 3′ End of RNAs by the Mitochondrial RNA Polymerase of Physarum polycephalum

2008 ◽  
Vol 28 (18) ◽  
pp. 5795-5802 ◽  
Author(s):  
Mara L. Miller ◽  
Dennis L. Miller
Keyword(s):  
Mitochondrial Dna ◽  
Rna Polymerase ◽  
Rna Editing ◽  
Physarum Polycephalum ◽  
Mitochondrial Gene ◽  
In Vitro Transcription ◽  
Open Reading Frames ◽  
Mitochondrial Rna ◽  
Mitochondrial Rna Polymerase

ABSTRACT Mitochondrial gene expression is necessary for proper mitochondrial biogenesis. Genes on the mitochondrial DNA are transcribed by a dedicated mitochondrial RNA polymerase (mtRNAP) that is encoded in the nucleus and imported into mitochondria. In the myxomycete Physarum polycephalum, nucleotides that are not specified by the mitochondrial DNA templates are inserted into some RNAs, a process called RNA editing. This is an essential step in the expression of these RNAs, as the insertion of the nontemplated nucleotides creates open reading frames for the production of proteins from mRNAs or produces required secondary structure in rRNAs and tRNAs. The nontemplated nucleotide is added to the 3′ end of the RNA as the RNA is being synthesized during mitochondrial transcription. Because RNA editing is cotranscriptional, the mtRNAP is implicated in RNA editing as well as transcription. We have cloned the cDNA for the mtRNAP of Physarum and have expressed the mtRNAP in Escherichia coli. We have used in vitro transcription assays based on the Physarum mtRNAP to identify a novel activity associated with the mtRNAP in which non-DNA-templated nucleotides are added to the 3′ end of RNAs. Any of the four ribonucleoside triphosphates (rNTPs) can act as precursors for this process, and this novel activity is observed when only one rNTP is supplied, a condition under which transcription does not occur. The implications of this activity for the mechanism of RNA editing are discussed.

Tissue-specific Distribution of Multiple Mitochondrial DNA Rearrangements during Human Aginga

1998 ◽  
Vol 854 (1 TOWARDS PROLO) ◽  
pp. 171-181 ◽  
Author(s):  
SERGEY A. KOVALENKO ◽  
GEORGE KOPSIDAS ◽  
JOANNE KELSO ◽  
FRANKLIN ROSENFELDT ◽  
ANTHONY W. LINNANE
Keyword(s):  
Mitochondrial Dna ◽  
Dna Rearrangements ◽  
Tissue Specific ◽  
Specific Distribution

scholarly journals Polymorphism and Uniparental Inheritance of Mitochondrial DNA in Physarum polycephalum

Microbiology ◽  
1987 ◽  
Vol 133 (11) ◽  
pp. 3175-3182 ◽  
Author(s):  
S. Kawano ◽  
R. W. Anderson ◽  
T. Nanba ◽  
T. Kuroiwa
Keyword(s):  
Mitochondrial Dna ◽  
Physarum Polycephalum ◽  
Uniparental Inheritance
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