Synthesis of chitosan derivatives with quaternary ammonium salt and their antibacterial activity

1997 ◽  
Vol 38 (4) ◽  
pp. 387-393 ◽  
Author(s):  
Chun Ho Kim ◽  
Jang Won Choi ◽  
Heung Jae Chun ◽  
Kyu Suk Choi
Keyword(s):  
Antibacterial Activity ◽  
Ammonium Salt ◽  
Quaternary Ammonium ◽  
Quaternary Ammonium Salt ◽  
Chitosan Derivatives

Antibacterial activity of quaternary ammonium salt grafted cotton

2007 ◽  
Vol 98 (3) ◽  
pp. 209-218 ◽  
Author(s):  
N. Ladhari ◽  
M. H. V. Baouab ◽  
Abdelbasset Ben Dekhil ◽  
Amina Bakhrouf ◽  
P. Niquette
Keyword(s):  
Antibacterial Activity ◽  
Ammonium Salt ◽  
Quaternary Ammonium ◽  
Quaternary Ammonium Salt

scholarly journals Preparation of Cross-linked Chitosan Quaternary Ammonium Salt Hydrogel Films Loading Drug of Gentamicin Sulfate for Antibacterial Wound Dressing

Marine Drugs ◽  
2021 ◽  
Vol 19 (9) ◽  
pp. 479
Author(s):  
Jingjing Zhang ◽  
Wenqiang Tan ◽  
Qing Li ◽  
Xiaorui Liu ◽  
Zhanyong Guo
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Ammonium Salt ◽  
Quaternary Ammonium ◽  
Quaternary Ammonium Salt ◽  
Wound Dressing ◽  
Cross Linking ◽  
And Staphylococcus Aureus ◽  
Hydrogel Films

Hydrogels, possessing high biocompatibility and adaptability to biological tissue, show great usability in medical applications. In this research, a series of novel cross-linked chitosan quaternary ammonium salt loading with gentamicin sulfate (CTMCSG) hydrogel films with different cross-linking degrees were successfully obtained by the reaction of chitosan quaternary ammonium salt (TMCS) and epichlorohydrin. Fourier transform infrared spectroscopy (FTIR), thermal analysis, and scanning electron microscope (SEM) were used to characterize the chemical structure and surface morphology of CTMCSG hydrogel films. The physicochemical property, gentamicin sulphate release behavior, cytotoxicity, and antibacterial activity of the CTMCSG against Escherichia coli and Staphylococcus aureus were determined. Experimental results demonstrated that CTMCSG hydrogel films exhibited good water stability, thermal stability, drug release capacity, as well as antibacterial property. The inhibition zone of CTMCSG hydrogel films against Escherichia coli and Staphylococcus aureus could be up to about 30 mm. Specifically, the increases in maximum decomposition temperature, mechanical property, water content, swelling degree, and a reduction in water vapor permeability of the hydrogel films were observed as the amount of the cross-linking agent increased. The results indicated that the CTMCSG-4 hydrogel film with an interesting physicochemical property, admirable antibacterial activity, and slight cytotoxicity showed the potential value as excellent antibacterial wound dressing.

scholarly journals Antibacterial Activity of Quaternary Ammonium Salt from Diethylaminoethyl Methacrylate

2010 ◽  
Vol 7 (s1) ◽  
pp. S61-S66 ◽  
Author(s):  
Makhloufia Mohammed ◽  
BenaÏssa Tahar ◽  
Derdour AÏcha ◽  
Henni Djamel Eddine
Keyword(s):  
Antibacterial Activity ◽  
Klebsiella Pneumoniae ◽  
Ammonium Salt ◽  
Quaternary Ammonium ◽  
Quaternary Ammonium Salt ◽  
Inhibitory Concentration ◽  
Gram Negative Bacteria ◽  
Inhibitory Zone ◽  
Gram Negative ◽  
Gram Positive Bacteria

A quaternary ammonium salt was synthesized from diethylaminoethyl methacrylate (DEAEMA) by quaternization with hexadecyl bromide. The resultant compound (Am-h) was characterized by FTIR and NMR spectroscopy. Its bactericidal activity was evaluated by determining minimum inhibitory concentration (MIC) values and inhibitory zone diameter against gram positive bacteria (Streptococcus sp.) and gram negative bacteria such asAcenito baumannii, Klebsiella pneumoniaeandProteus sp. respectively. The results showed that the MIC values of the synthesised compound (Am-h) were 2 μg/mL againstAcenito baumannii, Klebsiella pneumoniae, Proteus sp. and Streptococcus sp.

Microstructure and antibacterial performance of functionalized polyurethane based on polysiloxane tethered cationic biocides

RSC Advances ◽  
2015 ◽  
Vol 5 (95) ◽  
pp. 77508-77517 ◽  
Author(s):  
Qinghua Zhang ◽  
Hailong Liu ◽  
Xiaoli Zhan ◽  
Fengqiu Chen ◽  
Jie Yan ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Free Energy ◽  
Antibacterial Activity ◽  
Surface Free Energy ◽  
Ammonium Salt ◽  
Quaternary Ammonium ◽  
Quaternary Ammonium Salt ◽  
Antibacterial Performance ◽  
Special Surface

The designed polyurethane containing polysiloxanes tethered quaternary ammonium salt groups exhibited special surface migrations, low surface free energy and excellent antibacterial activity towardsEscherichia coli.

Preparation and characterization of reactive chitosan quaternary ammonium salt and its application in antibacterial finishing of cotton fabric

2016 ◽  
Vol 87 (6) ◽  
pp. 759-765 ◽  
Author(s):  
W Zhang ◽  
JJ Zhou ◽  
XL Dai
Keyword(s):  
Antibacterial Activity ◽  
Ammonium Chloride ◽  
Cotton Fabric ◽  
Ammonium Salt ◽  
Chemical Reaction ◽  
Quaternary Ammonium ◽  
Quaternary Ammonium Salt ◽  
Antibacterial Activities ◽  
Water Soluble ◽  
Better Than

The water soluble and reactive O-methyl acrylamide quaternary ammonium salt of chitosan (NMA-HTCC) was prepared with a view to develop an antibacterial finishing on cotton fabric. 2-hydroxypropyltrimethyl ammonium chloride chitosan (HTCC) was synthesized by the chemical reaction of chitosan and 2,3-epoxypropyltrimethyl ammonium chloride. Then, NMA-HTCC with reactive groups was synthesized by the chemical reaction of HTCC and N-(hydroxymethyl) –acrylamide, and its chemical structure was characterized by the Fourier transform infrared spectroscopy and nuclear magnetic resonance (NMR). The antibacterial activities of chitosan and NMA-HTCC were tested and compared by the minimal inhibitory method. Cotton fabrics were finished by NMA-HTCC under the alkalinity condition using sodium bicarbonate as the catalyst. The antibacterial activity of cotton fabric before and after finishing was measured by the oscillation flask method. The results showed that both chitosan and NMA-HTCC had a significant antibacterial effect on staphylococcus and coli, and the antibacterial activity of NMA-HTCC was better than that of chitosan. The antibacterial activity of cotton fabric to staphylococcus and coli were significantly improved after finishing by chitosan and NMA-HTCC, and the antibacterial activity of the cotton fabric finished by NMA-HTCC was better than that finished by chitosan.

Preparation and Characterization of Two New Kinds of Soluble Quaternary Ammonium Salts of Chitosan

2011 ◽  
Vol 239-242 ◽  
pp. 496-500
Author(s):  
Li Ju Tan ◽  
He Dong Wang ◽  
Jiang Tao Wang
Keyword(s):  
Schiff Base ◽  
Ammonium Salt ◽  
Quaternary Ammonium ◽  
Quaternary Ammonium Salt ◽  
Quaternary Ammonium Salts ◽  
Ammonium Salts ◽  
Resonance Spectroscopy ◽  
Spectra Analysis ◽  
Chitosan Derivatives ◽  
H Nmr

Schiff base of chitosan was obtained by the reaction of chitosan and aromatic aldehyde, and then Schiff base of chitosan reacted with methyl iodide to get soluble quaternary ammonium salts of chitosan which were N-metoxybenzenemethyl quaternary ammonium salt of chitosan (NM- Chitosan) and N-hydroxybenzenemethyl quaternary ammonium salt of chitosan(NH-Chitosan). The obtained chitosan derivatives were characterized by Infrared Spectra Analysis(FT-IR), Nuclear Magnetic Resonance Spectroscopy(1H NMR) and elemental analysis. Quantitative analysis showed that there was small difference between degrees of quaternization(DQ) and degrees of substitution(DS), and the solubility of chitosan derivatives was demonstrated to be better in the organic solvents.

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