Induction of oocyte maturation by jun -N-terminal kinase (JNK) on the oncogenic ras -p21 pathway is dependent on the raf -MEK-MAP kinase signal transduction pathway

2000 ◽  
Vol 45 (6) ◽  
pp. 441-449 ◽  
Author(s):  
L. Chie ◽  
S. Amar ◽  
H.-F. Kung ◽  
M. C. M. Lin ◽  
H. Chen ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Map Kinase ◽  
Oocyte Maturation ◽  
Signal Transduction Pathway ◽  
Transduction Pathway ◽  
Oncogenic Ras ◽  
Ras P21

scholarly journals Mating in Saccharomyces cerevisiae: The Role of the Pheromone Signal Transduction Pathway in the Chemotropic Response to Pheromone

Genetics ◽  
1997 ◽  
Vol 147 (1) ◽  
pp. 19-32 ◽  
Author(s):  
Kathrin Schrick ◽  
Barbara Garvik ◽  
Leland H Hartwell
Keyword(s):  
Signal Transduction ◽  
Map Kinase ◽  
Transcriptional Activation ◽  
Signal Transduction Pathway ◽  
Transduction Pathway ◽  
Wild Type ◽  
Mating Partner ◽  
Map Kinase Cascade ◽  
Kinase Cascade ◽  
Wild Type Control

Abstract The mating process in yeast has two distinct aspects. One is the induction and activation of proteins required for cell fusion in response to a pheromone signal; the other is chemotropism, i.e., detection of a pheromone gradient and construction of a fusion site available to the signaling cell. To determine whether components of the signal transduction pathway necessary for transcriptional activation also play a role in chemotropism, we examined strains with null mutations in components of the signal transduction pathway for diploid formation, prezygote formation and the chemotropic process of mating partner discrimination when transcription was induced downstream of the mutation. Cells mutant for components of the mitogen-activated protein (MAP) kinase cascade (ste5, ste20, ste11, ste7 or fus3 kss1) formed diploids at a frequency 1% that of the wild-type control, but formed prezygotes as efficiently as the wild-type control and showed good mating partner discrimination, suggesting that the MAP kinase cascade is not essential for chemotropism. In contrast, cells mutant for the receptor (ste2) or the β or γ subunit (ste4 and stel8) of the G protein were extremely defective in both diploid and prezygote formation and discriminated poorly between signaling and nonsignaling mating partners, implying that these components are important for chemotropism.

The Mak2 MAP kinase signal transduction pathway is required for pathogenicity in Stagonospora nodorum

2005 ◽  
Vol 48 (1) ◽  
pp. 60-68 ◽  
Author(s):  
Peter S. Solomon ◽  
Ormonde D. C. Waters ◽  
Joanne Simmonds ◽  
Richard M. Cooper ◽  
Richard P. Oliver
Keyword(s):  
Signal Transduction ◽  
Map Kinase ◽  
Signal Transduction Pathway ◽  
Stagonospora Nodorum ◽  
Transduction Pathway

scholarly journals Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway

2004 ◽  
Vol 23 (24) ◽  
pp. 4780-4791 ◽  
Author(s):  
Ole-Morten Seternes ◽  
Theresa Mikalsen ◽  
Bjarne Johansen ◽  
Espen Michaelsen ◽  
Chris G Armstrong ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Map Kinase ◽  
Signal Transduction Pathway ◽  
Transduction Pathway

scholarly journals The Drosophila rolled locus encodes a MAP kinase required in the sevenless signal transduction pathway.

1994 ◽  
Vol 13 (7) ◽  
pp. 1628-1635 ◽  
Author(s):  
W.H. Biggs ◽  
K.H. Zavitz ◽  
B. Dickson ◽  
A. van der Straten ◽  
D. Brunner ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Map Kinase ◽  
Signal Transduction Pathway ◽  
Transduction Pathway

The MAP kinase signal transduction pathway is activated by the endogenous cannabinoid anandamide

FEBS Letters ◽  
1995 ◽  
Vol 359 (2-3) ◽  
pp. 133-136 ◽  
Author(s):  
Markus Wartmann ◽  
Debra Campbell ◽  
Asha Subramanian ◽  
Sumner H. Burstein ◽  
Roger J. Davis
Keyword(s):  
Signal Transduction ◽  
Map Kinase ◽  
Signal Transduction Pathway ◽  
Transduction Pathway ◽  
Endogenous Cannabinoid

scholarly journals A role for autophosphorylation revealed by activated alleles of FUS3, the yeast MAP kinase homolog.

1994 ◽  
Vol 5 (3) ◽  
pp. 297-312 ◽  
Author(s):  
J A Brill ◽  
E A Elion ◽  
G R Fink
Keyword(s):  
Escherichia Coli ◽  
Signal Transduction ◽  
Map Kinase ◽  
Signal Transduction Pathway ◽  
Transduction Pathway ◽  
Phosphorylated Form ◽  
Protein Map ◽  
Mitogen Activated Protein ◽  
Mating Signal

We have isolated dominant gain-of-function (gf) mutations in FUS3, a Saccharomyces cerevisiae mitogen-activated protein (MAP) kinase homolog, that constitutively activate the yeast mating signal transduction pathway and confer hypersensitivity to mating pheromone. Surprisingly, the phenotypes of dominant FUS3gf mutations require the two protein kinases, STE7 and STE11. FUS3gf kinases are hyperphosphorylated in yeast independently of STE7. Consistent with this, FUS3gf kinases expressed in Escherichia coli exhibit an increased ability to autophosphorylate on tyrosine in vivo. FUS3gf mutations suppress the signal transduction defect of a severely catalytically impaired allele of STE7. This finding suggests that the tyrosine-phosphorylated form of FUS3 is a better substrate for activation by STE7. Furthermore, these results imply that the degree of autophosphorylation of a MAP kinase determines its threshold of sensitivity to upstream signals.

The ETS domain protein Pointed-P2 is a target of MAP kinase in the Sevenless signal transduction pathway

Nature ◽  
1994 ◽  
Vol 370 (6488) ◽  
pp. 386-389 ◽  
Author(s):  
Damian Brunner ◽  
Klaus Dücker ◽  
Nadja Oellers ◽  
Ernst Hafen ◽  
Henrike Scholzi ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Map Kinase ◽  
Signal Transduction Pathway ◽  
Transduction Pathway ◽  
Ets Domain ◽  
Domain Protein
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