Pharmacokinetics and pharmacodynamics of a novel protein kinase inhibitor, UCN-01

Noriaki Kurata; Takashi Kuwabara; Hiromi Tanii; Eiichi Fuse; Tadakazu Akiyama; Shiro Akinaga; Hiroyuki Kobayashi; Ken Yamaguchi; Satoshi Kobayashi

doi:10.1007/s002800050939

Pharmacokinetics and pharmacodynamics of a novel protein kinase inhibitor, UCN-01

Cancer Chemotherapy and Pharmacology ◽

10.1007/s002800050939 ◽

1999 ◽

Vol 44 (1) ◽

pp. 12-18 ◽

Cited By ~ 13

Author(s):

Noriaki Kurata ◽

Takashi Kuwabara ◽

Hiromi Tanii ◽

Eiichi Fuse ◽

Tadakazu Akiyama ◽

...

Keyword(s):

Protein Kinase ◽

Kinase Inhibitor ◽

Protein Kinase Inhibitor ◽

Pharmacokinetics And Pharmacodynamics ◽

Novel Protein

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Single-Dose Pharmacokinetics and Pharmacodynamics of RWJ 67657, a Specific p38 Mitogen-Activated Protein Kinase Inhibitor: A First-in-Human Study

The Journal of Clinical Pharmacology ◽

10.1177/0091270002250615 ◽

2003 ◽

Vol 43 (4) ◽

pp. 406-413 ◽

Cited By ~ 33

Author(s):

Dolly A. Parasrampuria ◽

Peter de Boer ◽

Daksha Desai-Krieger ◽

Andrew T. Chow ◽

C. Richard Jones

Keyword(s):

Single Dose ◽

Protein Kinase ◽

Kinase Inhibitor ◽

Human Study ◽

Protein Kinase Inhibitor ◽

Mitogen Activated Protein Kinase ◽

Pharmacokinetics And Pharmacodynamics ◽

Mitogen Activated Protein

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Radiation sensitization of prostate carcinoma cells by ONC 01910, a novel protein kinase inhibitor and cell cycle modulator

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2004.07.167 ◽

2004 ◽

Vol 60 (1) ◽

pp. S341 ◽

Cited By ~ 1

Author(s):

A.K. Sharma ◽

S. Mohan ◽

A. Alfieri ◽

M. Garg ◽

B. Xi ◽

...

Keyword(s):

Cell Cycle ◽

Protein Kinase ◽

Prostate Carcinoma ◽

Kinase Inhibitor ◽

Protein Kinase Inhibitor ◽

Carcinoma Cells ◽

Radiation Sensitization ◽

Novel Protein

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Midostaurin, a Novel Protein Kinase Inhibitor for the Treatment of Acute Myelogenous Leukemia: Insights from Human Absorption, Metabolism, and Excretion Studies of a BDDCS II Drug

Drug Metabolism and Disposition ◽

10.1124/dmd.116.072744 ◽

2017 ◽

Vol 45 (5) ◽

pp. 540-555 ◽

Cited By ~ 16

Author(s):

Handan He ◽

Phi Tran ◽

Helen Gu ◽

Vivienne Tedesco ◽

Jin Zhang ◽

...

Keyword(s):

Protein Kinase ◽

Acute Myelogenous Leukemia ◽

Kinase Inhibitor ◽

Protein Kinase Inhibitor ◽

Myelogenous Leukemia ◽

Acute Myelogenous ◽

Novel Protein

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A novel protein kinase inhibitor IMB-YH-8 with anti-tuberculosis activity

Scientific Reports ◽

10.1038/s41598-017-04108-7 ◽

2017 ◽

Vol 7 (1) ◽

Cited By ~ 15

Author(s):

Jian Xu ◽

Ju-xian Wang ◽

Jin-ming Zhou ◽

Chang-liang Xu ◽

Bin Huang ◽

...

Keyword(s):

Protein Kinase ◽

Kinase Inhibitor ◽

Protein Kinase Inhibitor ◽

Tuberculosis Activity ◽

Novel Protein

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Apoptosis is induced in leishmanial cells by a novel protein kinase inhibitor withaferin A and is facilitated by apoptotic topoisomerase I–DNA complex

Cell Death and Differentiation ◽

10.1038/sj.cdd.4402002 ◽

2006 ◽

Vol 14 (2) ◽

pp. 358-367 ◽

Cited By ~ 71

Author(s):

N Sen ◽

B Banerjee ◽

B B Das ◽

A Ganguly ◽

T Sen ◽

...

Keyword(s):

Protein Kinase ◽

Topoisomerase I ◽

Kinase Inhibitor ◽

Protein Kinase Inhibitor ◽

Withaferin A ◽

Dna Complex ◽

Novel Protein

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Role of protein kinases in stimulation of human polymorphonuclear leukocyte oxidative metabolism by various agonists. Differential effects of a novel protein kinase inhibitor.

Journal of Clinical Investigation ◽

10.1172/jci112302 ◽

1986 ◽

Vol 77 (1) ◽

pp. 61-65 ◽

Cited By ~ 156

Author(s):

C Gerard ◽

L C McPhail ◽

A Marfat ◽

N P Stimler-Gerard ◽

D A Bass ◽

...

Keyword(s):

Protein Kinase ◽

Protein Kinases ◽

Oxidative Metabolism ◽

Polymorphonuclear Leukocyte ◽

Kinase Inhibitor ◽

Protein Kinase Inhibitor ◽

Human Polymorphonuclear Leukocyte ◽

Novel Protein ◽

Stimulation Of

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Elongation factor-2 kinase: effective inhibition by the novel protein kinase inhibitor rottlerin and relative insensitivity towards staurosporine

FEBS Letters ◽

10.1016/0014-5793(94)80121-5 ◽

1994 ◽

Vol 338 (1) ◽

pp. 85-88 ◽

Cited By ~ 60

Author(s):

Michael Gschwendt ◽

Walter Kittstein ◽

Friedrich Marks

Keyword(s):

Protein Kinase ◽

Kinase Inhibitor ◽

Elongation Factor ◽

Protein Kinase Inhibitor ◽

The Novel ◽

Elongation Factor 2 ◽

Effective Inhibition ◽

Novel Protein

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Radiation sensitization of prostate carcinoma cells by ONC 01910, a novel protein kinase inhibitor and cell cycle modulator

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/s0360-3016(04)01471-3 ◽

2004 ◽

Vol 60 ◽

pp. S341-S341

Author(s):

A SHARMA ◽

S MOHAN ◽

A ALFIERI ◽

M GARG ◽

B XI ◽

...

Keyword(s):

Cell Cycle ◽

Protein Kinase ◽

Prostate Carcinoma ◽

Kinase Inhibitor ◽

Protein Kinase Inhibitor ◽

Carcinoma Cells ◽

Radiation Sensitization ◽

Novel Protein

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Rottlerin, a Novel Protein Kinase Inhibitor

Biochemical and Biophysical Research Communications ◽

10.1006/bbrc.1994.1199 ◽

1994 ◽

Vol 199 (1) ◽

pp. 93-98 ◽

Cited By ~ 635

Author(s):

M. Gschwendt ◽

H.J. Muller ◽

K. Kielbassa ◽

R. Zang ◽

W. Kittstein ◽

...

Keyword(s):

Protein Kinase ◽

Kinase Inhibitor ◽

Protein Kinase Inhibitor ◽

Novel Protein

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Protein kinase inhibitor K-252a and fusicoccin induce similar initial changes in ion transport of parsley suspension cells

Physiologia Plantarum ◽

10.1034/j.1399-3054.1992.850311.x ◽

1992 ◽

Vol 85 (3) ◽

pp. 483-488

Author(s):

Heinrich Kauss ◽

Wolfgang Jeblick ◽

Uwe Conrath

Keyword(s):

Protein Kinase ◽

Ion Transport ◽

Kinase Inhibitor ◽

Protein Kinase Inhibitor ◽

Suspension Cells

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