A pilot study of melphalan, tumor necrosis factor-α and 41.8 °C whole-body hyperthermia

1999 ◽  
Vol 43 (5) ◽  
pp. 409-414 ◽  
Author(s):  
H. I. Robins ◽  
D. M. Katschinski ◽  
W. Longo ◽  
E. Grosen ◽  
G. Wilding ◽  
...  
Keyword(s):  
Pilot Study ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Whole Body ◽  
Whole Body Hyperthermia ◽  
Factor Α ◽  
Necrosis Factor

Rheumatoid Hand Joint Synovitis: Gray-Scale and Power Doppler US Quantifications Following Anti–Tumor Necrosis Factor–α Treatment: Pilot Study

Radiology ◽  
2003 ◽  
Vol 229 (2) ◽  
pp. 562-569 ◽  
Author(s):  
Clio Ribbens ◽  
Béatrice André ◽  
Stefaan Marcelis ◽  
Olivier Kaye ◽  
Luc Mathy ◽  
...  
Keyword(s):  
Pilot Study ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Power Doppler ◽  
Gray Scale ◽  
Doppler Us ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Augmentation of Cancer Cachexia Components With Targeted Acupuncture in Patients With Gastrointestinal Cancers: A Randomized Controlled Pilot Study

2019 ◽  
Vol 18 ◽  
pp. 153473541882326 ◽  
Author(s):  
Oliver Grundmann ◽  
Saunjoo L. Yoon ◽  
Joseph J. Williams ◽  
Lucio Gordan ◽  
Thomas J. George
Keyword(s):  
Pilot Study ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Cancer Cachexia ◽  
Fat Free Mass ◽  
High Morbidity ◽  
Gi Cancer ◽  
Factor Α ◽  
Necrosis Factor

Introduction: Patients with gastrointestinal (GI) cancer-associated cachexia are at risk of high morbidity and mortality. This randomized single-blind pilot study compared the complementary use of targeted acupuncture (TA) with nontargeted acupuncture (NTA) for halting cachexia symptoms. Methods: GI cancer patients with cachexia undergoing chemotherapy were assigned to receive 8 weekly sessions of either TA (n = 15) or NTA (n = 15) following a specific acupuncture protocol. Bioelectrical impedance analysis and weight were measured weekly. Biological markers, including C-reactive protein, prealbumin, tumor necrosis factor-α, lactate dehydrogenase (LDH), leptin, and ghrelin blood levels were determined at specific intervals. Results: Prealbumin levels and fat-free mass were significantly higher in the NTA group at the end of the study, but remained stable in TA group. TA group had significantly lower (230 IU/L vs 288 IU/L, P = .04) LDH at the end of the study, but elevated tumor necrosis factor-α levels (13.15 pg/mL vs 9.24 pg/mL, P = .04). The absolute blood leptin and ghrelin levels decreased in the TA but remained stable in the NTA group. Both groups maintained weight, but the TA group trended toward weight gain during the last 2 weeks of the study. No adverse events related to acupuncture were reported. Conclusions: TA using predetermined, reproducible points may provide benefits to some patients with GI cancer cachexia by normalizing metabolic dysregulation. Elevated ghrelin levels are indicative of insulin resistance, which can lead to increased muscle loss represented by increased LDH activity in the NTA group. The pilot study provided completion rate and effect size for the primary outcome measures for a larger study. A longer treatment duration may be required to further refine these findings.

scholarly journals Five-Day Whole-Body Cryostimulation, Blood Inflammatory Markers, and Performance in High-Ranking Professional Tennis Players

2012 ◽  
Vol 47 (6) ◽  
pp. 664-672 ◽  
Author(s):  
Ewa Ziemann ◽  
Robert Antoni Olek ◽  
Sylwester Kujach ◽  
Tomasz Grzywacz ◽  
Jędrzej Antosiewicz ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Resting Metabolic Rate ◽  
Whole Body ◽  
Moderate Intensity ◽  
Tennis Players ◽  
Professional Tennis ◽  
Factor Α ◽  
Necrosis Factor

Context Tournament season can provoke overreaching syndrome in professional tennis players, which may lead to deteriorated performance. Thus, appropriate recovery methods are crucial for athletes in order to sustain high-level performance and avoid injuries. We hypothesized that whole-body cryostimulation could be applied to support the recovery process. Objective To assess the effects of 5 days of whole-body cryostimulation combined with moderate-intensity training on immunologic, hormonal, and hematologic responses; resting metabolic rate; and tennis performance in a posttournament season. Design Controlled laboratory study. Setting National Olympic Sport Centre. Patients or Other Participants Twelve high-ranking professional tennis players. Intervention(s) Participants followed a moderate-intensity training program. A subgroup was treated with the 5-day whole-body cryostimulation (−120°C) applied twice a day. The control subgroup participated in the training only. Main Outcome Measure(s) Pretreatment and posttreatment blood samples were collected and analyzed for tumor necrosis factor α, interleukin 6, testosterone, cortisol, and creatine kinase. Resting metabolic rate and performance of a tennis drill were also assessed. Results Proinflammatory cytokine (tumor necrosis factor α) decreased and pleiotropic cytokine (interleukin 6) and cortisol increased in the group exposed to cryostimulation. In the same group, greater stroke effectiveness during the tennis drill and faster recovery were observed. Neither the training program nor cryostimulation affected resting metabolic rate. Conclusions Professional tennis players experienced an intensified inflammatory response after the completed tournament season, which may lead to overreaching. Applying whole-body cryostimulation in conjunction with moderate-intensity training was more effective for the recovery process than the training itself. The 5-day exposure to cryostimulation twice a day ameliorated the cytokine profile, resulting in a decrease in tumor necrosis factor α and an increase in interleukin 6.

Advancing age and insulin resistance: role of plasma tumor necrosis factor-α

1998 ◽  
Vol 275 (2) ◽  
pp. E294-E299 ◽  
Author(s):  
Giuseppe Paolisso ◽  
Maria Rosaria Rizzo ◽  
Gherardo Mazziotti ◽  
Maria Rosaria Tagliamonte ◽  
Antonio Gambardella ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Insulin Action ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Fat Free Mass ◽  
Whole Body ◽  
Tnf Α ◽  
Factor Α ◽  
Necrosis Factor

In 70 healthy subjects with a large age range, the relationships between plasma tumor necrosis factor-α (TNF-α) and body composition, insulin action, and substrate oxidation were investigated. In the cross-sectional study ( n = 70), advancing age correlated with plasma TNF-α concentration ( r = 0.64, P < 0.001) and whole body glucose disposal (WBGD; r= −0.38, P < 0.01). The correlation between plasma TNF-α and age was independent of sex and body fat (BF; r = 0.31, P < 0.01). Independent of age and sex, a significant relationship between plasma TNF-α and leptin concentration ( r = 0.29, P < 0.02) was also found. After control for age, sex, BF, and waist-to-hip ratio (WHR), plasma TNF-α was still correlated with WBGD ( r = −0.33, P < 0.007). Further correction for plasma free fatty acid (FFA) concentration made the latter correlation no more significant. In a multivariate analysis, a model made by age, sex, BF, fat- free mass, WHR, and plasma TNF-α concentrations explained 69% of WBGD variability with age ( P < 0.009), BF ( P < 0.006), fat-free mass ( P < 0.005), and plasma TNF-α ( P < 0.05) significantly and independently associated with WBGD. In the longitudinal study, made with subjects at the highest tertiles of plasma TNF-α concentration ( n = 50), plasma TNF-α concentration predicted a decline in WBGD independent of age, sex, BF, WHR [relative risk (RR) = 2.0; 95% confidence intervals (CI) = 1.2–2.4]. After further adjustment for plasma fasting FFA concentration, the predictive role of fasting plasma TNF-α concentration on WBGD (RR = 1.2; CI = 0.8–1.5) was no more significant. In conclusion, our study demonstrates that plasma TNF-α concentration is significantly associated with advancing age and that it predicts the impairment in insulin action with advancing age.

scholarly journals Therapeutic Whole-body Hypothermia Protects Remote Lung, Liver, and Kidney Injuries after Blast Limb Trauma in Rats

2016 ◽  
Vol 124 (6) ◽  
pp. 1360-1371 ◽  
Author(s):  
Jiaolin Ning ◽  
Liwen Mo ◽  
Bin Yi ◽  
Jianteng Gu ◽  
Kaizhi Lu ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Interleukin 6 ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Whole Body ◽  
Myeloperoxidase Activity ◽  
Limb Trauma ◽  
Liver And Kidney ◽  
Factor Α ◽  
Necrosis Factor

Abstract Background Severe blast limb trauma (BLT) induces distant multiple-organ injuries. In the current study, the authors determined whether whole-body hypothermia (WH) and its optimal duration (if any) afford protection to the local limb damage and distant lung, liver, and kidney injuries after BLT in rats. Methods Rats with BLT, created by using chartaceous electricity detonators, were randomly treated with WH for 30 min, 60 min, 3 h, and 6 h (n = 12/group). Rectal temperature and arterial blood pressure were monitored throughout. Blood and lung, liver, and kidney tissue samples were harvested for measuring tumor necrosis factor-α, interleukin-6 and interleukin-10, myeloperoxidase activity, hydrogen sulfide, and biomarkers of oxidative stress at 6 h after BLT. The pathologic lung injury and the water content of the lungs, liver, and kidneys and blast limb tissue were assessed. Results Unlike WH for 30 min, WH for 60 min reduced lung water content, lung myeloperoxidase activity, and kidney myeloperoxidase activity by 10, 39, and 28% (all P &lt; 0.05), respectively. WH for 3 h attenuated distant vital organs and local traumatic limb damage and reduced myeloperoxidase activity, hydrogen peroxide and malondialdehyde concentration, and tumor necrosis factor-α and interleukin-6 levels by up to 49% (all P &lt; 0.01). Likewise, WH for 6 h also provided protection to such injured organs but increased blood loss from traumatic limb. Conclusions Results of this study indicated that WH may provide protection for distant organs and local traumatic limb after blast trauma, which warrants further study.

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