A clinical pharmacokinetics study of carzelesin given by short-term intravenous infusion in a phase I study

1998 ◽  
Vol 41 (5) ◽  
pp. 377-384 ◽  
Author(s):  
O. van Tellingen ◽  
C. J. A. Punt ◽  
Y. Groot ◽  
R. E. C. Henrar ◽  
A. Awada ◽  
...  
Keyword(s):  
Phase I ◽  
Intravenous Infusion ◽  
Phase I Study ◽  
Short Term ◽  
Clinical Pharmacokinetics ◽  
Pharmacokinetics Study

scholarly journals A phase I study of thiotepa administered by short-term and protracted continuous intravenous infusion

Cancer ◽  
1989 ◽  
Vol 63 (1) ◽  
pp. 46-50 ◽  
Author(s):  
Jacob J. Lokich ◽  
Merrill J. Egorin ◽  
Brian E. Cohen ◽  
Murray M. Bern ◽  
Thomas E. Zipoli ◽  
...  
Keyword(s):  
Phase I ◽  
Intravenous Infusion ◽  
Phase I Study ◽  
Continuous Intravenous Infusion ◽  
Short Term

Phase I trial of concurrent intraperitoneal and continuous intravenous infusion of fluorouracil in patients with refractory cancer.

1988 ◽  
Vol 6 (1) ◽  
pp. 158-162 ◽  
Author(s):  
B Reichman ◽  
M Markman ◽  
T Hakes ◽  
N Kemeny ◽  
D Kelsen ◽  
...  
Keyword(s):  
Phase I ◽  
Intravenous Infusion ◽  
Phase I Study ◽  
Clinical Utility ◽  
Phase I Trial ◽  
Drug Exposure ◽  
Continuous Intravenous Infusion ◽  
Future Studies ◽  
Systemic Drug Exposure ◽  
Systemic Drug

In an effort to maximize both local-regional and systemic drug exposure to tumor in the peritoneal cavity, a phase I study was conducted that examined the simultaneous daily intraperitoneal (IP) and continuous intravenous infusion (CVI) of fluorouracil (5-FU) to 32 patients with refractory cancer. IP 5-FU administered at 1,000 mg/d with concurrent 5-FU by CVI at 1,000 mg/m2/d for four consecutive days was well tolerated. One patient with a primary gastrointestinal (GI) malignancy with minimal volume disease experienced a surgically defined complete remission. In theory, this regimen may demonstrate clinical utility as an adjuvant treatment of certain GI malignancies. Future studies are planned in this clinical setting.

Phase I Study of Adozelesin Administered by 24-Hour Continuous Intravenous Infusion

1994 ◽  
Vol 86 (5) ◽  
pp. 368-372 ◽  
Author(s):  
G. F. Fleming ◽  
M. J. Ratain ◽  
S. M. O'Brien ◽  
R. L. Schilsky ◽  
P. C. Hoffman ◽  
...  
Keyword(s):  
Phase I ◽  
Intravenous Infusion ◽  
Phase I Study ◽  
Continuous Intravenous Infusion

Phase I Study of Retelliptine Dihydrochloride (SR 95325 B) Using a Single Two-Hour Intravenous Infusion Schedule

1994 ◽  
Vol 17 (3) ◽  
pp. 242-245 ◽  
Author(s):  
Joseph Kattan ◽  
Michel Durand ◽  
Jean-Pierre Droz ◽  
Monder Mahjoubi ◽  
Jean-Pierre Marino ◽  
...  
Keyword(s):  
Phase I ◽  
Intravenous Infusion ◽  
Phase I Study ◽  
Infusion Schedule

scholarly journals A Phase I Study of Cantuzumab Mertansine Administered as a Single Intravenous Infusion Once Weekly in Patients with Advanced Solid Tumors

2004 ◽  
Vol 10 (13) ◽  
pp. 4363-4368 ◽  
Author(s):  
Paul R. Helft ◽  
Richard L. Schilsky ◽  
Frank J. Hoke ◽  
Daphne Williams ◽  
Hedy L. Kindler ◽  
...  
Keyword(s):  
Phase I ◽  
Solid Tumors ◽  
Intravenous Infusion ◽  
Phase I Study ◽  
Advanced Solid Tumors ◽  
Single Intravenous Infusion

scholarly journals A phase I study of rhizoxin (NSC 332598) by 72-hour continuous intravenous infusion in patients with advanced solid tumors

2000 ◽  
Vol 11 (3) ◽  
pp. 333-338 ◽  
Author(s):  
A.W. Tolcher ◽  
C. Aylesworth ◽  
J. Rizzo ◽  
E. Izbicka ◽  
E. Campbell ◽  
...  
Keyword(s):  
Phase I ◽  
Solid Tumors ◽  
Intravenous Infusion ◽  
Phase I Study ◽  
Advanced Solid Tumors ◽  
Continuous Intravenous Infusion

A phase I study of human lymphoblastoid interferon administered by continuous intravenous infusion

1982 ◽  
Vol 9 (2) ◽  
pp. 97-102 ◽  
Author(s):  
A. Z. S. Rohatiner ◽  
F. R. Balkwill ◽  
D. B. Griffin ◽  
J. S. Malpas ◽  
T. A. Lister
Keyword(s):  
Phase I ◽  
Intravenous Infusion ◽  
Phase I Study ◽  
Continuous Intravenous Infusion ◽  
Lymphoblastoid Interferon
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