Synergistic effect of inhibitors of topoisomerase I and II on chromosome damage and cell killing in cultured Chinese hamster ovary cells

1994 ◽  
Vol 34 (5) ◽  
pp. 411-415
Author(s):  
Felipe Cort�s ◽  
Joaquin Pi�ero
Keyword(s):  
Synergistic Effect ◽  
Chinese Hamster Ovary ◽  
Topoisomerase I ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Cell Killing ◽  
Chromosome Damage ◽  
Ovary Cells ◽  
Effect Of Inhibitors

The role of O6-alkylguanine in cell killing and mutagenesis in Chinese hamster ovary cells

1991 ◽  
Vol 12 (1) ◽  
pp. 83-89 ◽  
Author(s):  
William C. Dunn ◽  
Keizo Tano ◽  
Gregory J. Horesovsky ◽  
R.Julian Preston ◽  
Sankar Mitra
Keyword(s):  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Cell Killing ◽  
Ovary Cells

Integrin αIIbβ3-Dependent ERK Signaling Is Regulated by Src and Rho Kinases in Both Leu33 and Pro33 Polymorphic Isoforms

2016 ◽  
Vol 137 (1) ◽  
pp. 44-50 ◽  
Author(s):  
Khon C. Huynh ◽  
Thi-Hiep Nguyen ◽  
Dinh Chuong Pham ◽  
Huong T.T. Nguyen ◽  
Toi Van Vo ◽  
...  
Keyword(s):  
Synergistic Effect ◽  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Erk Signaling ◽  
Signaling Cascades ◽  
Ovary Cells ◽  
Integrin Αiibβ3 ◽  
Erk2 Activation ◽  
Rho Kinases

Platelet integrin αIIbβ3 possesses a Leu/Pro polymorphism at residue 33 (Leu33/HPA-1a or Pro33/HPA-1b). The Pro33 isoform has been suggested to exhibit prothrombotic features. αIIbβ3-expressing CHO (Chinese hamster ovary) cells on immobilized fibrinogen show activation of the MAP kinase family member ERK2, with an enhanced ERK2 activity in Pro33 cells compared to Leu33 cells. In our present work, we examined how the Leu/Pro polymorphism modulates the ERK2 activation stimulated by 2 differently triggered outside-in signalings. We either treated the CHO cells with Mn2+ or allowed them to adhere to fibrinogen. Moreover, we studied which signaling cascades are involved in ERK2 activation. In contrast to immobilized fibrinogen, Mn2+ did not significantly increase ERK2 activation. However, Mn2+ had a synergistic effect on ERK2 phosphorylation when combined with immobilized fibrinogen. Pro33 cells adherent to fibrinogen exhibited a significantly greater ERK2 activity than Leu33 cells in the presence of Mn2+, which peaked after 10 min of adhesion. Our data showed that Src family and rho kinases play a crucial role in the integrin αIIbβ3-dependent outside-in signaling to ERK2.

Chromium(III) picolinate produces chromosome damage in Chinese hamster ovary cells.

1995 ◽  
Vol 9 (15) ◽  
pp. 1643-1648 ◽  
Author(s):  
D M Stearns ◽  
J P Wise ◽  
S R Patierno ◽  
K E Wetterhahn
Keyword(s):  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Chromosome Damage ◽  
Ovary Cells

scholarly journals XRCC1 Protects against Particulate Chromate–Induced Chromosome Damage and Cytotoxicity in Chinese Hamster Ovary Cells

2006 ◽  
Vol 92 (1) ◽  
pp. 96-102 ◽  
Author(s):  
Eliza Grlickova-Duzevik ◽  
Sandra S. Wise ◽  
Ray C. Munroe ◽  
W. Douglas Thompson ◽  
John Pierce Wise
Keyword(s):  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Chromosome Damage ◽  
Ovary Cells

Induction by H 2 O 2 of DNA and Interphase Chromosome Damage in Plateau-Phase Chinese Hamster Ovary Cells

1992 ◽  
Vol 131 (2) ◽  
pp. 192 ◽  
Author(s):  
George E. Iliakis ◽  
Gabriel E. Pantelias ◽  
Ryuichi Okayasu ◽  
William F. Blakely
Keyword(s):  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Chromosome Damage ◽  
Plateau Phase ◽  
Interphase Chromosome ◽  
Ovary Cells

scholarly journals XRCC1 Protects against Particulate Chromate–Induced Chromosome Damage and Cytotoxicity in Chinese Hamster Ovary Cells

2006 ◽  
Vol 92 (2) ◽  
pp. 409-415 ◽  
Author(s):  
Eliza Grlickova-Duzevik ◽  
Sandra S. Wise ◽  
Ray C. Munroe ◽  
W. Douglas Thompson ◽  
John Pierce Wise
Keyword(s):  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Chromosome Damage ◽  
Ovary Cells
Sign in / Sign up

Export Citation Format

Share Document