Cytogenetic findings in 175 patients indicate that items of the Kiel classification should not be disregarded in the REAL classification of lymphoid neoplasms

1996 ◽  
Vol 72 (5) ◽  
pp. 291-301 ◽  
Author(s):  
H. Nowotny ◽  
H. Karlic ◽  
H. Grüner ◽  
J. Hirsch ◽  
M. Vesely ◽  
...  
Keyword(s):  
The Real ◽  
Kiel Classification ◽  
Lymphoid Neoplasms

World Health Organization Classification of Neoplastic Diseases of the Hematopoietic and Lymphoid Tissues: Report of the Clinical Advisory Committee Meeting—Airlie House, Virginia, November 1997

1999 ◽  
Vol 17 (12) ◽  
pp. 3835-3849 ◽  
Author(s):  
Nancy Lee Harris ◽  
Elaine S. Jaffe ◽  
Jacques Diebold ◽  
Georges Flandrin ◽  
H. Konrad Muller-Hermelink ◽  
...  
Keyword(s):  
World Health Organization ◽  
Advisory Committee ◽  
Who Classification ◽  
Hematologic Malignancies ◽  
World Health ◽  
The Real ◽  
Lymphoid Neoplasms ◽  
Disease Entities ◽  
Health Organization

PURPOSE: The European Association of Hematopathologists and the Society for Hematopathology have developed a new World Health Organization (WHO) classification of hematologic malignancies, including lymphoid, myeloid, histiocytic, and mast cell neoplasms. DESIGN: Ten committees of pathologists developed lists and definitions of disease entities. A clinical advisory committee (CAC) of international hematologists and oncologists was formed to ensure that the classification would be useful to clinicians. The CAC met in November 1997 to discuss clinical issues related to the classification. RESULTS: The WHO uses the Revised European-American Lymphoma (REAL) classification, published in 1994 by the International Lymphoma Study Group, to categorize lymphoid neoplasms. The REAL classification is based on the principle that a classification is a list of “real” disease entities, which are defined by a combination of morphology, immunophenotype, genetic features, and clinical features. The relative importance of each of these features varies among diseases, and there is no one gold standard. The WHO classification applies the principles of the REAL classification to myeloid and histiocytic neoplasms. The classification of myeloid neoplasms recognizes distinct entities defined by a combination of morphology and cytogenetic abnormalities. At the CAC meeting, which was organized around a series of clinical questions, participants reached a consensus on most of the questions posed. They concluded that clinical groupings of lymphoid neoplasms were neither necessary nor desirable. Patient treatment is determined by the specific type of lymphoma, with the addition of grade within the tumor type, if applicable, and clinical prognostic factors, such as the International Prognostic Index. CONCLUSION: The WHO classification has produced a new and exciting degree of cooperation and communication between oncologists and pathologists from around the world, which should facilitate progress in the understanding and treatment of hematologic malignancies.

scholarly journals Proposed Modification of the "Real Working" Classification of Lymphoid Neoplasms

1997 ◽  
Vol 89 (20) ◽  
pp. 1546-1546 ◽  
Author(s):  
I. C. Haznedaroglu ◽  
Y. Buyukasik ◽  
M. Benekli ◽  
I. H. Gullu
Keyword(s):  
The Real ◽  
Lymphoid Neoplasms ◽  
Proposed Modification

scholarly journals Classification of lymphoid neoplasms: the microscope as a tool for disease discovery

Blood ◽  
2008 ◽  
Vol 112 (12) ◽  
pp. 4384-4399 ◽  
Author(s):  
Elaine S. Jaffe ◽  
Nancy Lee Harris ◽  
Harald Stein ◽  
Peter G. Isaacson
Keyword(s):  
Molecular Mechanisms ◽  
Nk Cell ◽  
Clinical Manifestations ◽  
Lymphoid Cells ◽  
World Health ◽  
International Studies ◽  
Lymphocyte Function ◽  
Lymphoid Neoplasms

AbstractIn the past 50 years, we have witnessed explosive growth in the understanding of normal and neoplastic lymphoid cells. B-cell, T-cell, and natural killer (NK)–cell neoplasms in many respects recapitulate normal stages of lymphoid cell differentiation and function, so that they can be to some extent classified according to the corresponding normal stage. Likewise, the molecular mechanisms involved the pathogenesis of lymphomas and lymphoid leukemias are often based on the physiology of the lymphoid cells, capitalizing on deregulated normal physiology by harnessing the promoters of genes essential for lymphocyte function. The clinical manifestations of lymphomas likewise reflect the normal function of lymphoid cells in vivo. The multiparameter approach to classification adopted by the World Health Organization (WHO) classification has been validated in international studies as being highly reproducible, and enhancing the interpretation of clinical and translational studies. In addition, accurate and precise classification of disease entities facilitates the discovery of the molecular basis of lymphoid neoplasms in the basic science laboratory.

scholarly journals Identification features of the minutes of interrogation and ways of authorship examination

2019 ◽  
Vol 17 (3) ◽  
pp. 97-108
Author(s):  
Elena E. Abramkina
Keyword(s):  
Current Paper ◽  
Authorship Attribution ◽  
Features Selection ◽  
New Classification ◽  
Semantic Type ◽  
The Real ◽  
Language Analysis ◽  
Authorship Analysis

Forensic authorship analysis is a frequently used technique to identify the real author of an arguable document. Often enough, under study are interrogation minutes. This kind of text is difficult for examination because of its stylistic and genre characteristics: formal phrases and structure as well as different author and compiler of the document. The above features restrict the use of some levels of language analysis. This issue, however, is poorly covered in specialist literature, with only a few articles related to it. The current paper describes the main discursive features of interrogation minutes used in authorship expertise. First we look at conventional techniques of authorship expertise and discuss their limitations. Special attention is given to the analysis of the interrogation minutes genre characteristics and their influence on the whole set of identifiers. The analysis of several conventional interrogation minutes techniques singled out two central tendencies in the authorship attribution: an identification features selection with new identifiers being added. The aim of the article is to propose a solution to the problem. Our technique is based on the methods of The Federal Ministry of the Interior, but it also takes into account genre charecteristics of the interrogation minutes. A new classification of identifiers has been developed. Additional features are offered to improve the attribution accuracy. These are clarifications, which are classified according to the semantic type of the object. In the article clarifications are divided into six types and a few subtypes and are also divided into low and high informative ones. The analysis of clarification is illustrated with the example of three different interrogation minutes. The concluding part of the article is concerned with the techniques of the interrogation minutes used in authorship expertise description, materials requirements and the steps of the analysis.

scholarly journals One Case of Forensic Clinical Identification of Ulnar Radius Fracture not Involving Epiphysis

2020 ◽  
Vol 1 (1) ◽  
Author(s):  
Dawei Jiang ◽  
Yujun Zhou
Keyword(s):  
Clinical Examination ◽  
Technical Specification ◽  
Epiphyseal Plate ◽  
Forensic Identification ◽  
The Real ◽  
Degree Of Disability ◽  
The Relationship ◽  
Case Data ◽  
Human Injury

In order to investigate the relationship between injury and injury of the identified person, to determine the real disability of the identified person, to determine whether the fracture of ulna and radius of the identified person is involved in the epiphysis, and to be commissioned by the court, the identified person is specially re-identified. According to the contents and methods of the Technical Specification for Forensic Identification (SF/ZJD0103003-2011) of the Ministry of Justice, the forensic clinical examination was conducted. After consulting the case data and conducting the forensic clinical examination of the identified person, this appraisal concluded that the left ulna and radius broken line of the patient disappeared, the epiphyseal plate was clear, and there was no deformity, and the disability grade was not constructed according to the provisions of the Classification of the degree of disability caused by human injury.

scholarly journals THE REAL ANATOMY OF COMPLEX LINEAR SUPERFIELDS

2012 ◽  
Vol 27 (24) ◽  
pp. 1250143 ◽  
Author(s):  
S. JAMES GATES ◽  
JARED HALLETT ◽  
TRISTAN HÜBSCH ◽  
KORY STIFFLER
Keyword(s):  
Recent Work ◽  
Vast Number ◽  
The Real ◽  
Explicit Analysis ◽  
Complex Linear

Recent work on classification of off-shell representations of N-extended worldline supersymmetry without central charges has uncovered an unexpectedly vast number — trillions of even just (chromo)topology types — of so-called adinkraic supermultiplets. Herein, we show by explicit analysis that a long-known but rarely used representation, the complex linear supermultiplet, is not adinkraic, cannot be decomposed locally, but may be reduced by means of a Wess–Zumino type gauge. This then indicates that the already unexpectedly vast number of adinkraic off-shell supersymmetry representations is but the proverbial tip of the iceberg.

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