Pulmonary fungal infections in patients with hematological malignancies ? diagnostic approaches

1995 ◽  
Vol 70 (3) ◽  
pp. 135-141 ◽  
Author(s):  
M. Z�hlsdorf ◽  
M. Hesse ◽  
R. Schulten ◽  
J. van de Loo ◽  
M. von Eiff ◽  
...  
Keyword(s):  
Hematological Malignancies ◽  
Fungal Infections ◽  
Diagnostic Approaches ◽  
Pulmonary Fungal Infections

Pulmonary fungal infections in patients with hematological malignancies — Diagnostic approaches

1995 ◽  
Vol 70 (3) ◽  
pp. 135-141 ◽  
Author(s):  
M. von Eiff ◽  
M. Zühlsdorf ◽  
N. Roos ◽  
M. Hesse ◽  
R. Schulten ◽  
...  
Keyword(s):  
Hematological Malignancies ◽  
Fungal Infections ◽  
Diagnostic Approaches ◽  
Pulmonary Fungal Infections

scholarly journals Surgery for Pulmonary Fungal Infections Complicating Hematological Malignancies

2018 ◽  
Vol 51 (5) ◽  
pp. 350-355 ◽  
Author(s):  
Takashi Yamamichi ◽  
Hirotoshi Horio ◽  
Ayaka Asakawa ◽  
Masayuki Okui ◽  
Masahiko Harada
Keyword(s):  
Hematological Malignancies ◽  
Fungal Infections ◽  
Pulmonary Fungal Infections

scholarly journals Trends of pulmonary fungal infections from 2013 to 2019: an AI-based real-world observational study in Guangzhou, China

2021 ◽  
Vol 10 (1) ◽  
pp. 450-460
Author(s):  
Zhengtu Li ◽  
Yongming Li ◽  
Yijun Chen ◽  
Jing Li ◽  
Shaoqiang Li ◽  
...  
Keyword(s):  
Observational Study ◽  
Real World ◽  
Fungal Infections ◽  
Pulmonary Fungal Infections

scholarly journals Risk of infection associated with targeted therapies for solid organ and hematological malignancies

2021 ◽  
Vol 8 ◽  
pp. 204993612198954
Author(s):  
Isabel Ruiz-Camps ◽  
Juan Aguilar-Company
Keyword(s):  
Hematological Malignancies ◽  
Opportunistic Infections ◽  
Respiratory Infections ◽  
Fungal Infections ◽  
Checkpoint Inhibitors ◽  
Janus Kinase ◽  
Prolonged Treatment ◽  
Solid Organ ◽  
Risk Of Infection ◽  
Increased Risk

Higher risks of infection are associated with some targeted drugs used to treat solid organ and hematological malignancies, and an individual patient’s risk of infection is strongly influenced by underlying diseases and concomitant or prior treatments. This review focuses on risk levels and specific suggestions for management, analyzing groups of agents associated with a significant effect on the risk of infection. Due to limited clinical experience and ongoing advances in these therapies, recommendations may be revised in the near future. Bruton tyrosine kinase (BTK) inhibitors are associated with a higher rate of infections, including invasive fungal infection, especially in the first months of treatment and in patients with advanced, pretreated disease. Phosphatidylinositol 3-kinase (PI3K) inhibitors are associated with an increased risk of Pneumocystis pneumonia and cytomegalovirus (CMV) reactivation. Venetoclax is associated with cytopenias, respiratory infections, and fever and neutropenia. Janus kinase (JAK) inhibitors may predispose patients to opportunistic and fungal infections; need for prophylaxis should be assessed on an individual basis. Mammalian target of rapamycin (mTOR) inhibitors have been linked to a higher risk of general and opportunistic infections. Breakpoint cluster region-Abelson (BCR-ABL) inhibitors are associated with neutropenia, especially over the first months of treatment. Anti-CD20 agents may cause defects in the adaptative immune response, hypogammaglobulinemia, neutropenia, and hepatitis B reactivation. Alemtuzumab is associated with profound and long-lasting immunosuppression; screening is recommended for latent infections and prevention strategies against CMV, herpesvirus, and Pneumocystis infections. Checkpoint inhibitors (CIs) may cause immune-related adverse events for which prolonged treatment with corticosteroids is needed: prophylaxis against Pneumocystis is recommended.

scholarly journals Pulmonary Fungal Infections Affect Patients With COVID-19

JAMA ◽  
2020 ◽  
Vol 324 (22) ◽  
pp. 2248
Author(s):  
Bridget M. Kuehn
Keyword(s):  
Fungal Infections ◽  
Pulmonary Fungal Infections

scholarly journals (1, 3)-β-D-glucan assay for diagnosing invasive fungal infections in critically ill patients with hematological malignancies

Oncotarget ◽  
2016 ◽  
Vol 7 (16) ◽  
pp. 21484-21495 ◽  
Author(s):  
Elie Azoulay ◽  
Nicolas Guigue ◽  
Michael Darmon ◽  
Djamel Mokart ◽  
Virginie Lemiale ◽  
...  
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Hematological Malignancies ◽  
Fungal Infections ◽  
Invasive Fungal Infections

scholarly journals Tuberculosis Status and Coinfection of Pulmonary Fungal Infections in Patients Referred to Reference Laboratory of Health Centers Ghaemshahr City during 2007-2017

1970 ◽  
Vol 28 (6) ◽  
Author(s):  
Mohammad Reza Jabbari Amiri ◽  
Rora Siami ◽  
Azad Khaledi
Keyword(s):  
Pulmonary Tuberculosis ◽  
Fungal Infections ◽  
Cross Sectional Study ◽  
Health Centers ◽  
Sputum Smear ◽  
P Value ◽  
Reference Laboratory ◽  
Cross Sectional ◽  
Pulmonary Fungal Infections ◽  
Student’S T

BACKGROUND: Pulmonary tuberculosis is one of the most important health concerns. Pulmonary fungal infections have clinical and radiological characteristics similar to tuberculosis which may be easily misdiagnosed as tuberculosis. This study aimed to evaluate tuberculosis (TB) status and coinfection of TB with pulmonary fungal infections in patients referred to reference laboratory of health centers Ghaemshahr city during 2007-2017.METHODS: This cross-sectional study was conducted during eleven years, between 2007 2017, on 3577 patients with suspected TB referred to health centers of Ghaemshahr City. For isolation, sputum smear preparation and Ziehl-Neelson staining in companying with microscopy direct observation and KOH 10% + white Calcofluor staining was used. The culture of fungi was performed on Sabouraud Dextrose agar, Czapek and chrome agar media. Then, data were analyzed using SPSS software (version 16) through Student's t-test, Fisher test, and Odds Ratio. P values <0.05 were considered statistically significant.RESULTS: Of 3577 patients, 10731 smears were prepared, 3.6% (n=130) of patients were identified as smear-positive pulmonary tuberculosis, 86.4% (n=3090) were smear negative and 10% (n=357) drug-resistant TB. The mean age of patients was 48±1.8 years. With increasing age, the prevalence of TB has increased which was statistically significant (P value <0.05). Prevalence of tuberculosis in the age group over than 57 years in males and females had an ascending trend. Amongst the positive tuberculosis patients, 16/130 cases (12.3%) had the coinfection of TB with fungi microorganisms.CONCLUSION: Our findings showed the coinfection of fungi agents in patients with tuberculosis that should be considered. 

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