Sjögren's syndrome associated with multiple myeloma

2000 ◽  
Vol 79 (8) ◽  
pp. 449-451 ◽  
Author(s):  
E. Terpos ◽  
M. K. Angelopoulou ◽  
E. Variami ◽  
J. C. Meletis ◽  
G. Vaiopoulos
Keyword(s):  
Multiple Myeloma ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Sjögren‘S Syndrome

scholarly journals Detection of t(14;16)(q32;q22) and Monosomy 13 by FISH Analysis in a Patient with Multiple Myeloma Associated with Sjögren’s Syndrome: The First Case Report from India

2013 ◽  
Vol 2013 ◽  
pp. 1-3
Author(s):  
Rupesh R. Sanap ◽  
Arundhati S. Athalye ◽  
Prochi F. Madon ◽  
Boman N. Dhabhar ◽  
Mahendra B. Sute ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Bone Marrow ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Malignant Neoplasm ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Fish Analysis ◽  
First Case ◽  
Sjögren‘S Syndrome

Sjögren’s syndrome (SS) is a chronic slowly progressive autoimmune disorder characterized by symptoms of oral and ocular dryness, exocrine dysfunction, and lymphocytic infiltration of exocrine glands. Multiple myeloma (MM) is a bone-marrow-based malignant neoplasm of plasma cells associated with serum/urine monoclonal paraproteins and lytic skeletal lesions. There have been very few reported cases of MM, who had SS as the first presentation. We report a case of a woman diagnosed with Sjögren’s syndrome, who was later suspected to have multiple myeloma on serum protein electrophoresis. Fluorescencein situhybridization (FISH) was carried out to check for deletions of loci 13q14.3, ATM, p53, and IGH (14q32) rearrangements on a bone marrow aspirate. Monosomy 13 was observed in 49% of cells, and a rearrangement at the IGH locus was seen in 42% of cells. To determine the partner chromosome associated with the IGH rearrangement, further FISH tests were set up for t(4;14)(p16;q32) followed by t(14;16)(q32;q22) on fresh slides. The test was negative for t(4;14) but positive for t(14;16) in 27% of cells. This confirmed the diagnosis of MM. We report the first case from India, having an association of Sjögren’s syndrome with multiple myeloma, which showed t(14;16) and monosomy 13 by FISH analysis.

scholarly journals Multiple Myeloma and Primary Sjogren’s Syndrome Combined with Unexplained Elevation of CA-125 Levels

2019 ◽  
pp. 208-213
Author(s):  
Jun Du ◽  
ShuHui Deng ◽  
LuGui Qiu ◽  
Gang An
Keyword(s):  
Multiple Myeloma ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Primary Sjögren’S Syndrome ◽  
Ca 125 ◽  
Primary Sjogren’S Syndrome ◽  
Primary Sjögren's Syndrome ◽  
Sjögren‘S Syndrome

Background: Multiple myeloma (MM) and its precursor, monoclonal gammopathy of undetermined significance (MGUS), have been linked with several autoimmune conditions like primary Sjögren’s Syndrome (pSS). Several studies link MM with autoimmune disorders. However, the data has not yet been fully analyzed or systematized.Case presentation: We described a 60-year-old Chinese woman diagnosed as multiple myeloma who presented with ocular and oral sicca symptoms, unexplained elevation of CA-125. In this patient, there was an inner connection between MM and pSS remaining to be investigated further.Conclusions: Multiple myeloma and primary Sjögren’s Syndrome could be coexisting due to the similar physiopathologic mechanism, which might be the explanation of bortezomib’s effectiveness. Moreover, tumor marker like CA-125 might be elevated owing to the secretion of CD-138+ve plasma cells.

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