Protective Effects of Antithrombin III Supplementation on Warm Ischemia and Reperfusion Injury in Rat Liver

1996 ◽  
Vol 20 (8) ◽  
pp. 1069-1075 ◽  
Author(s):  
Keiichi Okano ◽  
Yasutaka Kokudo ◽  
Kenji Okajima ◽  
Mohammad Akram Hossain ◽  
Ken Ishimura ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Rat Liver ◽  
Antithrombin Iii ◽  
Warm Ischemia ◽  
Ischemia And Reperfusion ◽  
Protective Effects ◽  
Ischemia And Reperfusion Injury

The effect of FK506 on Warm Ischemia and reperfusion Injury in the Rat Liver

Surgery Today ◽  
1994 ◽  
Vol 24 (11) ◽  
pp. 994-1002 ◽  
Author(s):  
Hisao Wakabayashi ◽  
Yukihiko Karasawa ◽  
Satoshi Tanaka ◽  
Yasutaka Kokudo ◽  
Takashi Maeba
Keyword(s):  
Reperfusion Injury ◽  
Rat Liver ◽  
Warm Ischemia ◽  
Ischemia And Reperfusion ◽  
Ischemia And Reperfusion Injury

Verapamil and flunarizine protect the isolated perfused rat liver against warm ischemia and reperfusion injury

1995 ◽  
Vol 195 (1) ◽  
pp. 61-68 ◽  
Author(s):  
Thomas Konrad ◽  
Christian Bloechle ◽  
Garry Haller ◽  
Christoph E. Broelsch ◽  
Klaus Henning Usadel ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Rat Liver ◽  
Warm Ischemia ◽  
Isolated Perfused Rat Liver ◽  
Ischemia And Reperfusion ◽  
Perfused Rat Liver ◽  
Ischemia And Reperfusion Injury

WARM ISCHEMIA AND REPERFUSION INJURY IN DIET-INDUCED CANINE FATTY LIVERS

2000 ◽  
Vol 69 (10) ◽  
pp. 2028-2034 ◽  
Author(s):  
Katsuro Takahashi ◽  
Kenichi Hakamada ◽  
Eishi Totsuka ◽  
Yutaka Umehara ◽  
Mutsuo Sasaki
Keyword(s):  
Reperfusion Injury ◽  
Warm Ischemia ◽  
Ischemia And Reperfusion ◽  
Ischemia And Reperfusion Injury ◽  
Fatty Livers

Antioxidant and protective effects of silymarin on ischemia and reperfusion injury in the kidney tissues of rats

2008 ◽  
Vol 40 (2) ◽  
pp. 453-460 ◽  
Author(s):  
Faruk Turgut ◽  
Omer Bayrak ◽  
Ferhat Catal ◽  
Reyhan Bayrak ◽  
Ali Fuat Atmaca ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia And Reperfusion ◽  
Protective Effects ◽  
Ischemia And Reperfusion Injury

scholarly journals Protective Effects and Target Network Analysis of Ginsenoside Rg1 in Cerebral Ischemia and Reperfusion Injury: A Comprehensive Overview of Experimental Studies

Cells ◽  
2018 ◽  
Vol 7 (12) ◽  
pp. 270 ◽  
Author(s):  
Weijie Xie ◽  
Ping Zhou ◽  
Yifan Sun ◽  
Xiangbao Meng ◽  
Ziru Dai ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Cerebral Ischemia ◽  
Reperfusion Injury ◽  
Ischemia And Reperfusion ◽  
Protective Effects ◽  
Pharmacological Effects ◽  
Ginsenoside Rg1 ◽  
Ischemia And Reperfusion Injury ◽  
Neuroprotective Effects ◽  
Cerebral Ischemia And Reperfusion

Cerebral ischemia-reperfusion is a complicated pathological process. The injury and cascade reactions caused by cerebral ischemia and reperfusion are characterized by high mortality, high recurrence, and high disability. However, only a limited number of antithrombotic drugs, such as recombinant tissue plasminogen activator (r-TPA), aspirin, and heparin, are currently available for ischemic stroke, and its safety concerns is inevitable which associated with reperfusion injury and hemorrhage. Therefore, it is necessary to further explore and examine some potential neuroprotective agents with treatment for cerebral ischemia and reperfusion injury to reduce safety concerns caused by antithrombotic drugs in ischemic stroke. Ginseng Rg1 (G-Rg1) is a saponin composed of natural active ingredients and derived from the roots or stems of Panax notoginseng and ginseng in traditional Chinese medicine. Its pharmacological effects exert remarkable neurotrophic and neuroprotective effects in the central nervous system. To explore and summarize the protective effects and mechanisms of ginsenoside Rg1 against cerebral ischemia and reperfusion injury, we conducted this review, in which we searched the PubMed database to obtain and organize studies concerning the pharmacological effects and mechanisms of ginsenoside Rg1 against cerebral ischemia and reperfusion injury. This study provides a valuable reference and clues for the development of new agents to combat ischemic stroke. Our summarized review and analysis show that the pharmacological effects of and mechanisms underlying ginsenoside Rg1 activity against cerebral ischemia and reperfusion injury mainly involve 4 sets of mechanisms: anti-oxidant activity and associated apoptosis via the Akt, Nrf2/HO-1, PPARγ/HO-1, extracellular regulated protein kinases (ERK), p38, and c-Jun N-terminal kinase (JNK) pathways (or mitochondrial apoptosis pathway) and the caspase-3/ROCK1/MLC pathway; anti-inflammatory and immune stimulatory-related activities that involve apoptosis or necrosis via MAPK pathways (the JNK1/2 + ERK1/2 and PPARγ/HO-1 pathways), endoplasmic reticulum stress (ERS), high mobility group protein1 (HMGB1)-induced TLR2/4/9 and receptor for advanced glycation end products (RAGE) pathways, and the activation of NF-κB; neurological cell cycle, proliferation, differentiation, and regeneration via the MAPK pathways (JNK1/2 + ERK1/2, PI3K-Akt/mTOR, PKB/Akt and HIF-1α/VEGF pathways); and energy metabolism and the regulation of cellular ATP levels, the blood-brain barrier and other effects via N-methyl-D-aspartic acid (NMDA) receptors, ERS, and AMP/AMPK-GLUT pathways. Collectively, these mechanisms result in significant neuroprotective effects against cerebral ischemic injury. These findings will be valuable in that they should further promote the development of candidate drugs and provide more information to support the application of previous findings in stroke clinical trials.

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