scholarly journals Matrix metalloproteinases in patients with osteoarthritis of the hip

2000 ◽  
Vol 24 (2) ◽  
pp. 92-96 ◽  
Author(s):  
K. Masuhara ◽  
S. Bak Lee ◽  
T. Nakai ◽  
N. Sugano ◽  
T. Ochi ◽  
...  
Keyword(s):  
Matrix Metalloproteinases ◽  
Osteoarthritis Of The Hip

scholarly journals Significant increases in serum and plasma concentrations of matrix metalloproteinases 3 and 9 in patients with rapidly destructive osteoarthritis of the hip

2002 ◽  
Vol 46 (10) ◽  
pp. 2625-2631 ◽  
Author(s):  
Kensaku Masuhara ◽  
Tsuyoshi Nakai ◽  
Katsuyuki Yamaguchi ◽  
Satoshi Yamasaki ◽  
Yasuyuki Sasaguri
Keyword(s):  
Matrix Metalloproteinases ◽  
Plasma Concentrations ◽  
Osteoarthritis Of The Hip ◽  
Destructive Osteoarthritis

Cytokine synergy, collagenases and cartilage collagen breakdown

2003 ◽  
Vol 70 ◽  
pp. 125-133 ◽  
Author(s):  
Tim E. Cawston ◽  
Jenny M. Milner ◽  
Jon B. Catterall ◽  
Andrew D. Rowan
Keyword(s):  
Matrix Metalloproteinases ◽  
Inflammatory Cytokines ◽  
Activator Protein 1 ◽  
Activator Protein ◽  
And Cartilage ◽  
Pro Inflammatory Cytokines

We have investigated proteinases that degrade cartilage collagen. We show that pro-inflammatory cytokines act synergistically with oncastatin M to promote cartilage collagen resorption by the up-regulation and activation of matrix metalloproteinases (MMPs). The precise mechanisms are not known, but involve the up-regulation of c-fos, which binds to MMP promoters at a proximal activator protein-1 (AP-1) site. This markedly up-regulates transcription and leads to higher levels of active MMP proteins.

Sign in / Sign up

Export Citation Format

Share Document