Systemically available bone morphogenetic protein two and seven affect bone metabolism

2014 ◽  
Vol 38 (9) ◽  
pp. 1979-1985 ◽  
Author(s):  
Ivo Dumic-Cule ◽  
Jelena Brkljacic ◽  
Dunja Rogic ◽  
Tatjana Bordukalo Niksic ◽  
Ana Tikvica Luetic ◽  
...  
Keyword(s):  
Bone Metabolism ◽  
Bone Morphogenetic Protein ◽  
Morphogenetic Protein ◽  
Affect Bone Metabolism

scholarly journals Effects of Estrogen on Bone mRNA Levels of Sclerostin and Other Genes Relevant to Bone Metabolism in Postmenopausal Women

2014 ◽  
Vol 99 (1) ◽  
pp. E81-E88 ◽  
Author(s):  
Koji Fujita ◽  
Matthew M. Roforth ◽  
Susan Demaray ◽  
Ulrike McGregor ◽  
Salman Kirmani ◽  
...  
Keyword(s):  
Bone Metabolism ◽  
Postmenopausal Women ◽  
Bone Morphogenetic Protein ◽  
Estrogen Treatment ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Mrna Levels ◽  
Morphogenetic Protein ◽  
Genome Wide ◽  
Bone Biopsies

Context: Studies in postmenopausal women have shown that estrogen reduces circulating sclerostin levels, but effects of estrogen on skeletal sclerostin mRNA levels are unknown. Objective: The objective of the study was to evaluate the effects of short-term estrogen treatment on bone mRNA levels of sclerostin and other genes relevant to bone metabolism. Design, Setting, and Patients: Needle bone biopsies were obtained from 20 postmenopausal women treated with transdermal estrogen for 3 weeks and 20 untreated controls. Quantitative PCR analyses were used to examine the expression of sclerostin and other genes related to bone metabolism, including 71 additional genes linked to bone density/fracture from genome-wide association studies. Results: Estrogen treatment was associated with lower bone sclerostin mRNA levels (by 48%, P < .05) and with lower (by 54%, P < .01) mRNA levels of the sclerostin-related protein, sclerostin domain-containing protein 1 (SOSTDC1), which is also a Wnt/bone morphogenetic protein inhibitor. Consistent with studies in mice showing that ovariectomy increased nuclear factor-κB (NF-κB) activation, we found that estrogen treatment was associated with a significant reduction in inflammatory genes as a group (P = .028), with bone mRNA levels of NFKB2 and RELB (both encoding proteins in the NF-κB transcription factor complex) being significantly reduced individual genes. Eight of the 71 genome-wide association study-related genes examined were modulated by estrogen (P < .05, false discovery rate < 0.10). Conclusion: In humans, estrogen-induced decreases in two key inhibitors of Wnt/bone morphogenetic protein signaling, sclerostin and SOSTDC1, along with reductions in NF-κB signaling, may be responsible for at least part of the protective effects of estrogen on bone.

Targeting bone morphogenetic protein antagonists:in vitroandin vivoevidence of their role in bone metabolism

2008 ◽  
Vol 13 (1) ◽  
pp. 123-137 ◽  
Author(s):  
Evaggelos Tsialogiannis ◽  
Ioannis Polyzois ◽  
Quen Oak Tang ◽  
George Pavlou ◽  
Evgenios Tsiridis ◽  
...  
Keyword(s):  
Bone Metabolism ◽  
Bone Morphogenetic Protein ◽  
Morphogenetic Protein

Effect of Bone Morphogenetic Protein (BMP)-2 and BMP-7 on bone metabolism in Thyroid-Parathyroid Deprivated (TPTX) rats

Bone ◽  
2009 ◽  
Vol 44 ◽  
pp. S335-S336
Author(s):  
N. Draca ◽  
P. Simic ◽  
A. Tikvica ◽  
D. Rogic ◽  
I. Dumic ◽  
...  
Keyword(s):  
Bone Metabolism ◽  
Bone Morphogenetic Protein ◽  
Morphogenetic Protein

Expression, signalling and potential in vivo functions of Bone Morphogenetic Protein (BMP)-9 in the liver

2009 ◽  
Vol 47 (01) ◽  
Author(s):  
K Breitkopf ◽  
A Müller ◽  
L Ciuclan ◽  
E Wiercinska ◽  
P ten Dijke ◽  
...  
Keyword(s):  
Bone Morphogenetic Protein ◽  
Morphogenetic Protein
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