Sensitization of resting T cells to autologous natural-killer-cell-mediated lysis by phytohemagglutinin

1999 ◽  
Vol 48 (9) ◽  
pp. 507-516
Author(s):  
Lea Baraz ◽  
Moshe Kotler ◽  
Reba Condiotti ◽  
Arnon Nagler
Keyword(s):  
T Cells ◽  
Natural Killer Cell ◽  
Natural Killer ◽  
Killer Cell

Comparing of pan-cancer tumor immune microenvironment.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e15100-e15100
Author(s):  
Jiaan Ye ◽  
Longgang Cui ◽  
Xiaochen Zhao ◽  
Guanghui Lan
Keyword(s):  
Colorectal Cancer ◽  
T Cells ◽  
Natural Killer Cell ◽  
Natural Killer ◽  
Cancer Patients ◽  
Killer Cell ◽  
Immune Microenvironment ◽  
Hepatobiliary Cancer ◽  
Tumor Immune Microenvironment ◽  
Pan Cancer

e15100 Background: Cancer treatment has entered the era of immune checkpoint inhibitors (ICI), but different tumors have different responses to ICI drugs. For example, non-small cell lung cancer and melanoma have higher response rates to ICIs than colorectal cancer and liver cancer patients. Previous studies have shown that tumor immune microenvironment have a great impact on the efficacy of ICI. Methods: This study retrospectively included pan-cancer patient specimens, using multiple fluorescent labeling immunohistochemistry to explore the differences in the immune microenvironment of different tumors. Shapiro-Wilk was used for normality test, and ANOVA or Kruskal Wallis test was used according to the results. Two-sided P < 0.05 was considered a significant difference. Results: The study included 308 patients, including 119 (38.6%) NSCLC patients, 72 (23.4%) Colorectal cancer patients, 51 (16.6%) Hepatobiliary cancer patients and 66 (21.4%) Others types of cancer patients. Among them, there was 192 (62.3%) Male, and 116 (37.7%) Female, and the median age was 57 (50-66). The proportion of CD8+ T cells and natural killer cell in tumor was statistically different. The proportion of CD8+ T cells in NSCLC, Colorectal cancer, Hepatobiliary cancer and others was 2.16%, 1%, 1.77% and 2.63%, p < 0.01; the proportion of natural killer cell was 16.44 %, 4.91%, 5.58% and 3.29%, p < 0.01. Conclusions: Different tumor types have different immune microenvironments. These results may provide valuable clues for future ICI trail design.

scholarly journals Suppression of natural killer cell-mediated bone marrow cell rejection by CD4+CD25+ regulatory T cells

2006 ◽  
Vol 103 (14) ◽  
pp. 5460-5465 ◽  
Author(s):  
I. Barao ◽  
A. M. Hanash ◽  
W. Hallett ◽  
L. A. Welniak ◽  
K. Sun ◽  
...  
Keyword(s):  
Bone Marrow ◽  
T Cells ◽  
Natural Killer Cell ◽  
Regulatory T Cells ◽  
Natural Killer ◽  
Bone Marrow Cell ◽  
Marrow Cell ◽  
Killer Cell

Combined Low Dose Cyclosporine and Prednisone Down-Regulate Natural Killer Cell-Like Effector Functions of CD8brightCD56+ T Cells in Patients with Active Behçet Uveitis

2006 ◽  
Vol 14 (5) ◽  
pp. 267-275 ◽  
Author(s):  
Jae Kyoun Ahn ◽  
Yeoung Geol Park ◽  
Sang Woo Park ◽  
Kyung-Chul Yoon ◽  
Hyeong Gon Yu ◽  
...  
Keyword(s):  
T Cells ◽  
Natural Killer Cell ◽  
Natural Killer ◽  
Low Dose ◽  
Killer Cell ◽  
Effector Functions
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