Cathepsin D antigenic epitopes identified by the humoral responses of ovarian cancer patients

1998 ◽  
Vol 46 (1) ◽  
pp. 48-54 ◽  
Author(s):  
Sreenavasa R. Chinni ◽  
C. Gerçel-Taylor ◽  
Gregory E. Conner ◽  
D. D. Taylor
Keyword(s):  
Ovarian Cancer ◽  
Cancer Patients ◽  
Cathepsin D ◽  
Humoral Responses ◽  
Antigenic Epitopes

Cellular and humoral responses after multiple injections of unconjugated chimeric monoclonal antibody MOv18 in ovarian cancer patients: a pilot study

2002 ◽  
Vol 128 (9) ◽  
pp. 484-492 ◽  
Author(s):  
Iwona van Zanten-Przybysz ◽  
Carla Molthoff ◽  
Jacqueline Gebbinck ◽  
Silvia von Mensdorff-Pouilly ◽  
Rob Verstraeten ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Monoclonal Antibody ◽  
Pilot Study ◽  
Cancer Patients ◽  
Multiple Injections ◽  
Chimeric Monoclonal Antibody ◽  
Humoral Responses

scholarly journals DETECTION OF OXIDATIVE STRESS, APOPTOSIS AND MOLECULAR LESIONS IN HUMAN OVARIAN CANCER CELLS

2016 ◽  
Author(s):  
H. I. Falfushynska
Keyword(s):  
Oxidative Stress ◽  
Ovarian Cancer ◽  
Cancer Patients ◽  
Cathepsin D ◽  
Control Level ◽  
Protein Carbonyls ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer ◽  
Key Words Ovarian Cancer ◽  
Choline Esterase

<p>Background. Ovarian cancer has the highest mortality rate of gynaecological cancers. This is partly due to<br />the lack of effective screening markers. Indices of oxidative stress are well-recognized prognostic criteria for<br />tumorous transformation of tissue, but their value depends on the type of tumor and the stage of its development.<br />Objective. The aim of this study is to clarify the relationship between antioxidant/pro-oxidant ratio and the<br />signs of molecular lesions and apoptosis rate in blood of ovarian cancer patients and non-cancer ones.<br />Results. The ovarian cancer group is marked by antioxidant/prooxidant balance shifting to oxidative damage<br />in blood as the consequence of overexpression of oxyradicals (by 300%). Higher level of glutathione (by 366%),<br />lower level of metallothioneins (by 65%) as well as higher level of lipid peroxidation (by 174%) and protein carbonyls<br />(by 186%) in blood of ovarian cancer patients compared to the normal ovarian group have been observed. The<br />signs of cytotoxicity are determined in blood of ovarian cancer patients: an increased (compared to control) level<br />of DNA fragmentation (by 160%), choline esterase (up to twice), higher rate of both caspase dependent and<br />caspase independent lysosomal mediated apoptosis.<br />Conclusions. Cathepsin D activity both total and free, choline esterase activity, TBA-reactive substance and<br />protein carbonyls level in blood could be used as the predictive markers of worse prognosis and the signs of<br />human ovarian cancer.<br />KEY WORDS: ovarian cancer, oxidative stress, apoptosis, caspase-3, cathepsin D, choline esterase,<br />metallothionein.</p>

Characterization of humoral responses of ovarian cancer patients: Antibody subclasses and antigenic components

2010 ◽  
Vol 116 (2) ◽  
pp. 213-221 ◽  
Author(s):  
Douglas D. Taylor ◽  
Safinur Atay ◽  
Daniel S. Metzinger ◽  
Cicek Gercel-Taylor
Keyword(s):  
Ovarian Cancer ◽  
Cancer Patients ◽  
Humoral Responses

Immunoreactive score of Ep-CAM might predict survival in early ovarian cancer patients

2011 ◽  
Vol 71 (08) ◽  
Author(s):  
MJ Battista ◽  
J Steetskamp ◽  
N Mantai ◽  
S Gebhard ◽  
C Cotarelo ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Patients ◽  
Early Ovarian Cancer

ROLE OF LIPID PROFILE IN OVARIAN CARCINOMA PATIENTS

2019 ◽  
Vol 3 (8) ◽  
Author(s):  
Dr. Manisha ◽  
Dr. Ruchi Jindal
Keyword(s):  
Ovarian Cancer ◽  
Lipid Profile ◽  
Cancer Patients ◽  
Ovarian Tumor ◽  
Ovarian Cancer Risk ◽  
Low Level ◽  
Medical College ◽  
Group I ◽  
History Of

Background: The term "ovarian cancer" includes several different types of cancer that  arise from cells of the ovary, most commonly, tumors arise from the epithelium or lining cells of the ovary.  Ovarian cancer risk is positively associated with higher consumption of dietary cholesterol and eggs, and inversely associated with a higher intake of vegetables. High consumption of fats may increase circulating estrogen levels, thus increasing the possibility of cell damage and proliferation that is responsible for cancerous growth. Material & Methods: The present study was conducted at Geetanjali Medical College and Hospital, Udaipur (Rajasthan). Total  100 cases (females) attending the obstetrics and gynecology department for some gynecological and other problem  were selected for this study between the age of 40-60 years, who were attending cancer centre at GEETANJALI MEDICAL COLLEGE AND  HOSPITAL, Udaipur (Rajasthan).                GROUP I: - It consisted of healthy females control subjects (n=50) .By routine examination and tests, we ensured that all the subjects were healthy and there were no signs and symptoms or history of ovarian tumor and diseases GROUP II: - It consisted of ovarian cancer females subjects (n=50) with a history of ovarian tumor. Results:   Higher level of cholesterol, LDL, VLDL and low level of HDL are found in ovarian cancer patients. Conclusion: The present study we highlights the importance and role of serum lipid profile in diagnosis, prognosis and recurrence of the disease. The study shows that serum level of cholesterol, LDL, VLDL was elevated in  patients of ovarian cancer while low level of HDL are found in ovarian cancer patients. Key words: lipid profile, ovarian cancer.

Frequency of blood transfusions for anemia due to chemotherapy in ovarian cancer patients. Thoughts to the guidelines modified in 2006 for the treatment of anemic cancer patients by the European Organisation for Research and Treatment of Cancer

2007 ◽  
Vol 148 (45) ◽  
pp. 2133-2137 ◽  
Author(s):  
Ottó Lehoczky ◽  
Tamás Pulay
Keyword(s):  
Ovarian Cancer ◽  
Cancer Patients ◽  
Blood Transfusions ◽  
European Organisation

2006-ban jelent meg az Európai Rákkutatási és Kezelési Szervezet korábbi megállapításokat korszerűsítő ajánlása, amelyben a rákos betegekben kialakuló anémia kezelésére adott vértranszfúziót, illetve az ezt követő erythropoetin-kezeléseket értékelik. Az ajánlásban a vértranszfúziót a 9 g% hemoglobinszintre csökkenő anémia esetén javasolják. Eddig a kemoterápia következtében kialakult anémia vértranszfúziós kezelésére egyértelműen meghatározott hemoglobin-határértékszint Magyarországon nem szerepelt. Cél: A szerzők az osztályukon 2005-ben kezelt petefészekrákos betegeknek adott vértranszfúziók gyakoriságát vizsgálták. Nemzetközi, illetve hazai egyértelmű ajánlás hiányában a vizsgálati időszakban a vértranszfúziókat – a beteg klinikai állapotát is figyelembe véve – a 10 g%-ot elérő anémia esetén alkalmazták. Anyag és módszer: Az Országos Onkológiai Intézet Nőgyógyászati Osztályán 190 hám eredetű, petefészekrákos betegben történt kemoterápia. Ha a hemoglobinszint 10 g% alá csökkent, választott vörösvértest-transzfúziót végeztek, majd a betegek többségében (51/64 = 79,6%), erythropoetin-kezelés történt. Eredmény: A 190 közül 64 betegnél (64/190 = 34%) történt vérátömlesztés a kemoterápia kapcsán kialakult anémia miatt, s az utóbbiaknak csaknem felében (34/64 = 53%) 1-nél több alkalommal végeztek vértranszfúziót. A betegek 86%-ában a vértranszfúzióra G2-súlyosságú anémia miatt került sor. Az ismételten szükséges vértranszfúziókat a leggyakrabban a carboplatin-gemcitabin- (16/16) kezelések után alkalmazták. Következtetés: A petefészekrákokban adott kemoterápiák a betegek harmadában okoznak 10 g%-nál súlyosabb fokú anémiát. A vérszegénység kezelésében a vértranszfúzión kívül gondolni kell az erythropoetin-készítmények alkalmazására.

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