Combination immunotherapy with OK-432, recombinant granulocyte-colony-stimulating factor and recombinant interleukin-2 for human hepatocellular carcinoma

1996 ◽  
Vol 42 (2) ◽  
pp. 127-131 ◽  
Author(s):  
T. Himoto ◽  
Seishiro Watanabe ◽  
Mikio Nishioka ◽  
Takashi Maeba ◽  
Satoshi Tanaka ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Interleukin 2 ◽  
Human Hepatocellular Carcinoma ◽  
Combination Immunotherapy ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Recombinant Interleukin 2 ◽  
Stimulating Factor

DOWNREGULATION OF BOTH INTERLEUKIN-12 AND INTERLEUKIN-2 IN HEART ALLOGRAFTS BY PRETRANSPLANT HOST TREATMENT WITH GRANULOCYTE COLONY-STIMULATING FACTOR AND TACROLIMUS

Cytokine ◽  
2002 ◽  
Vol 18 (3) ◽  
pp. 164-167 ◽  
Author(s):  
Hiroyuki Egi ◽  
Keisuke Hayamizu ◽  
Teruhiko Kitayama ◽  
Ichiro Ohmori ◽  
Masazumi Okajima ◽  
...  
Keyword(s):  
Interleukin 2 ◽  
Interleukin 12 ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Stimulating Factor

A potential therapeutic role for small nonpeptidyl compounds that mimic human granulocyte colony-stimulating factor

Blood ◽  
2004 ◽  
Vol 103 (3) ◽  
pp. 836-842 ◽  
Author(s):  
Kouji Kusano ◽  
Shinji Ebara ◽  
Koichi Tachibana ◽  
Tadahiro Nishimura ◽  
Susumu Sato ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Interleukin 2 ◽  
Immune Defense ◽  
Mitogen Activated Protein Kinase ◽  
Human Neutrophils ◽  
Blood Neutrophil ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Stimulating Factor

AbstractGranulocyte colony-stimulating factor (G-CSF) stimulates the proliferation of bone marrow granulocytic progenitor cells and promotes their differentiation into granulocytes. G-CSF is therefore an important component of immune defense against pathogenic microorganisms: recombinant human G-CSF (rhG-CSF) is used to treat patients with a variety of neutropenias. In the present study, we screened approximately 10 000 small nonpeptidyl compounds and found 3 small compounds that mimic G-CSF in several in vitro and in vivo assays. These compounds induced G-CSF–dependent proliferation, but had no effect on interleukin-3–dependent, interleukin-2–dependent, interleukin-10–dependent, thrombopoietin (TPO)–dependent, or erythropoietin (EPO)–dependent proliferation. Each compound induced the phosphorylation of signal transducers and activators of transcription–3 (STAT3) and mitogen-activated protein kinase (MAPK) in a G-CSF–dependent cell line and in human neutrophils. In addition, these compounds induced hematopoietic colony formation from primary rat bone marrow cells in vitro. When subcutaneously injected into normal rats, they caused an increase in peripheral blood neutrophil counts. Furthermore, when they were administered to cyclophosphamide-induced neutropenic rats, blood neutrophil levels increased and remained elevated up to day 8. We therefore suggest that these small nonpeptidyl compounds mimic the activity of G-CSF and may be useful in the treatment of neutropenic patients.

scholarly journals A Case of Granulocyte-Colony Stimulating Factor-Producing Hepatocellular Carcinoma Confirmed by Immunohistochemistry

2010 ◽  
Vol 25 (3) ◽  
pp. 476 ◽  
Author(s):  
Satoru Joshita ◽  
Koh Nakazawa ◽  
Shoichiro Koike ◽  
Atsushi Kamijo ◽  
Kiyoshi Matsubayashi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Stimulating Factor

scholarly journals pH Dependence of structural stability of interleukin-2 and granulocyte colony-stimulating factor

2003 ◽  
Vol 12 (5) ◽  
pp. 1030-1038 ◽  
Author(s):  
Margaret Speed Ricci ◽  
Casim A. Sarkar ◽  
Eric M. Fallon ◽  
Douglas A. Lauffenburger ◽  
David N. Brems
Keyword(s):  
Structural Stability ◽  
Ph Dependence ◽  
Interleukin 2 ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Stimulating Factor

scholarly journals Granulocyte colony-stimulating factor-producing hepatocellular carcinoma with abrupt changes

2016 ◽  
Vol 7 (5) ◽  
pp. 380 ◽  
Author(s):  
Hiroaki Nagata ◽  
Shuhei Komatsu ◽  
Wataru Takaki ◽  
Tokunari Okayama ◽  
Yasunori Sawabe ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Abrupt Changes ◽  
Stimulating Factor

Granulocyte-colony-stimulating-factor-producing hepatocellular carcinoma

1999 ◽  
Vol 34 (5) ◽  
pp. 640-644 ◽  
Author(s):  
Sumie Yamamoto ◽  
Shuji Takashima ◽  
Hiroyuki Ogawa ◽  
Toshifumi Kuroda ◽  
Mitsunari Yamamoto ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Stimulating Factor
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