CD4 + T lymphocytes infiltrating human breast cancer recognise autologous tumor in an MHC-class-II restricted fashion

1995 ◽  
Vol 40 (1) ◽  
pp. 1-9 ◽  
Author(s):  
R. Dadmarz ◽  
Magdalene K. Sgagias ◽  
Steven A. Rosenberg ◽  
Douglas J. Schwartzentruber
Keyword(s):  
Breast Cancer ◽  
T Lymphocytes ◽  
Mhc Class Ii ◽  
Human Breast Cancer ◽  
Class Ii ◽  
Autologous Tumor ◽  
Human Breast

scholarly journals CD4+ T lymphocytes infiltrating human breast cancer recognise autologous tumor in an MHC-class-II restricted fashion

1995 ◽  
Vol 41 (3) ◽  
pp. 201-201
Author(s):  
Roya Dadmarz ◽  
Magdalena K. Sgagias ◽  
Steven A. Rosenberg ◽  
Doulas J. Schwartzentruber
Keyword(s):  
Breast Cancer ◽  
T Lymphocytes ◽  
Mhc Class Ii ◽  
Human Breast Cancer ◽  
Class Ii ◽  
Autologous Tumor ◽  
Human Breast

CD4+ T lymphocytes infiltrating human breast cancer recognise autologous tumor in an MHC-class-II restricted fashion

1995 ◽  
Vol 40 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Roya Dadmarz ◽  
Magdalene K. Sgagias ◽  
Steven A. Rosenberg ◽  
Douglas J. Schwartzentruber
Keyword(s):  
Breast Cancer ◽  
T Lymphocytes ◽  
Mhc Class Ii ◽  
Human Breast Cancer ◽  
Class Ii ◽  
Autologous Tumor ◽  
Human Breast

Activation of regulatory T cells instigates functional down-regulation of cytotoxic T lymphocytes in human breast cancer

2011 ◽  
Vol 51 (1) ◽  
pp. 71-79 ◽  
Author(s):  
Chao-Hsu Li ◽  
Wen-Hong Kuo ◽  
Wen-Chun Chang ◽  
Su-Cheng Huang ◽  
King-Jen Chang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
T Cells ◽  
T Lymphocytes ◽  
Regulatory T Cells ◽  
Cytotoxic T Lymphocytes ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Down Regulation

Induction of tumor-specific cytotoxic T lymphocytes from regional lymph node lymphocytes of human breast cancer

Breast Cancer ◽  
1998 ◽  
Vol 5 (4) ◽  
pp. 367-373 ◽  
Author(s):  
Ryozo Eifuku ◽  
Ichiro Yoshino ◽  
Satoru Imahayashi ◽  
Hiroshi Fujie ◽  
Mitsuhiro Takenoyama ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes ◽  
Human Breast Cancer ◽  
Regional Lymph Node ◽  
Human Breast

scholarly journals Tumor-Infiltrating γδ T Lymphocytes Predict Clinical Outcome in Human Breast Cancer

2012 ◽  
Vol 189 (10) ◽  
pp. 5029-5036 ◽  
Author(s):  
Chunling Ma ◽  
Qunyuan Zhang ◽  
Jian Ye ◽  
Fang Wang ◽  
Yanping Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
T Lymphocytes ◽  
Clinical Outcome ◽  
Human Breast Cancer ◽  
Human Breast

Cytotoxicity of Cord Blood Derived Her2/neu-specific Cytotoxic T Lymphocytes against Human Breast Cancer in vitro and in vivo

2004 ◽  
Vol 83 (1) ◽  
pp. 15-23 ◽  
Author(s):  
Peng Wang ◽  
Corey M. Munger ◽  
Avadhut D. Joshi ◽  
Samuel J. Pirruccello ◽  
Shantaram S. Joshi
Keyword(s):  
Breast Cancer ◽  
T Lymphocytes ◽  
Cord Blood ◽  
Cytotoxic T Lymphocytes ◽  
Human Breast Cancer ◽  
Human Breast

scholarly journals A Role for T-Lymphocytes in Human Breast Cancer and in Canine Mammary Tumors

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Maria Isabel Carvalho ◽  
Isabel Pires ◽  
Justina Prada ◽  
Felisbina L. Queiroga
Keyword(s):  
Breast Cancer ◽  
T Lymphocytes ◽  
Human Breast Cancer ◽  
Survival Rates ◽  
Mammary Tumors ◽  
Treg Cells ◽  
Th2 Cells ◽  
Human Breast ◽  
Canine Mammary Tumors ◽  
As Relationship

Chronic inflammation in the tumor microenvironment has a prominent role in carcinogenesis and benefits the proliferation and survival of malignant cells, promoting angiogenesis and metastasis. Mammary tumors are frequently infiltrated by a heterogeneous population of immune cells where T-lymphocytes have a great importance. Interestingly, similar inflammatory cell infiltrates, cytokine and chemokine expression in humans and canine mammary tumors were recently described. However, in both species, despite all the scientific evidences that appoint for a significant role of T-lymphocytes, a definitive conclusion concerning the effectiveness of T-cell dependent immune mechanisms has not been achieved yet. In the present review, we describe similarities between human breast cancer and canine mammary tumors regarding tumor T-lymphocyte infiltration, such as relationship of TILs and mammary tumors malignancy, association of ratio CD4+/ CD8+ T-cells with low survival rates, promotion of tumor progression by Th2 cells actions, and association of great amounts of Treg cells with poor prognostic factors. This apparent parallelism together with the fact that dogs develop spontaneous tumors in the context of a natural immune system highlight the dog as a possible useful biological model for studies in human breast cancer immunology.

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