Patients with oral squamous cell carcinoma are characterized by increased frequency of suppressive regulatory T cells in the blood and tumor microenvironment

2009 ◽  
Vol 59 (6) ◽  
pp. 819-828 ◽  
Author(s):  
Thaís Helena Gasparoto ◽  
Tatiana Salles de Souza Malaspina ◽  
Luciana Benevides ◽  
Edgard Jose Franco de Melo ◽  
Maria Renata Sales Nogueira Costa ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
T Cells ◽  
Tumor Microenvironment ◽  
Oral Squamous Cell Carcinoma ◽  
Regulatory T Cells ◽  
Cell Carcinoma ◽  
Squamous Cell

scholarly journals CD4+CD25hiCD127low Regulatory T Cells Are Increased in Oral Squamous Cell Carcinoma Patients

PLoS ONE ◽  
2014 ◽  
Vol 9 (8) ◽  
pp. e103975 ◽  
Author(s):  
Kue Peng Lim ◽  
Nicole Ai Leng Chun ◽  
Siti Mazlipah Ismail ◽  
Mannil Thomas Abraham ◽  
Mohd Nury Yusoff ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
T Cells ◽  
Oral Squamous Cell Carcinoma ◽  
Regulatory T Cells ◽  
Cell Carcinoma ◽  
Squamous Cell

scholarly journals CD4+ CD25+ regulatory T-cells role in tumor microenvironment of the squamous cell carcinoma

2021 ◽  
Vol 62 (1) ◽  
pp. 249-253
Author(s):  
Andrei Vasile Paşcalău ◽  
◽  
Cornel Dragoş Cheregi ◽  
Mihai Ştefan Mureşan ◽  
Mircea Ioan Şandor ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
T Cells ◽  
Tumor Microenvironment ◽  
Regulatory T Cells ◽  
Cell Carcinoma ◽  
Squamous Cell

scholarly journals FOXP3/CD8 ratio and CXCR4-positive regulatory T cells as indicators of tumor immunity in the conjunctival squamous cell carcinoma microenvironment

2021 ◽  
Author(s):  
Mizuki Tagami ◽  
Anna Kakehashi ◽  
Atsuko Katsuyama-Yoshikawa ◽  
Atsushi Sakai ◽  
Norihiko Misawa ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
T Cells ◽  
Tumor Microenvironment ◽  
Regulatory T Cells ◽  
Cell Carcinoma ◽  
Tumor Immunity ◽  
Squamous Cell ◽  
Ocular Surface ◽  
Conjunctival Squamous Cell Carcinoma ◽  
Significant Difference

Abstract Conjunctival squamous cell carcinoma (SCC) is the most common ocular surface neoplasia. The purpose of this retrospective study was to examine the role of regulatory T cells (Tregs) activity in tumor immunity and investigate the tumor microenvironment as a new treatment focus in conjunctival SCC. A cancer progression gene array analysis and Immunohistochemical analysis of FOXP3 as Treg marker, CD8 as Tumor-infiltrating lymphocyte marker, and CXCR4 expression on activate Treg was also examined in a series of 31 conjunctival SCC cases. To investigate the localization of FOXP3-positive Tregs in detail, the tumor surface, tumor central, and around vessels staining patterns of FOXP3, CD8, and CXCR4 were examined separately. A significant difference in FOXP3, CD8, and CXCR4 staining in tumor-infiltrating lymphocytes and FOXP3/CD8 ratio were in the carcinoma in situ group than advanced stage SCC group(each P < 0.01). In addition, FOXP3/CD8 ratio was correlation with progression-free survival. Double immunostaining of CXCR4/FOXP3 correlate with American Joint Committee on Cancer T-stage, independent of age or Ki67 index(P༜0.01). Our results show that FOXP3, the FOXP3/CD8 ratio, and the CXCR4 axis are important pathologic and prognostic factors of ocular surface neoplasia, including SCC. These tumor microenvironment of conjunctival SCC may be considered in the future development of treatment options.

scholarly journals Tumor Microenvironment, HLA Class I and APM Expression in HPV-Negative Oral Squamous Cell Carcinoma

Cancers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 620
Author(s):  
Claudia Wickenhauser ◽  
Daniel Bethmann ◽  
Matthias Kappler ◽  
Alexander Walter Eckert ◽  
André Steven ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
T Cells ◽  
Tumor Microenvironment ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cd8 T Cells ◽  
Immune Cell ◽  
Hla Class I ◽  
Ifn Γ

Progression of oral squamous cell carcinoma (OSCC) has been associated with an escape of tumor cells from the host immune surveillance due to an increased knowledge of its underlying molecular mechanisms and its modulation by the tumor microenvironment and immune cell repertoire. In this study, the expression of HLA class I (HLA-I) antigens and of components of the antigen processing machinery (APM) was analyzed in 160 pathologically classified human papilloma virus (HPV)-negative OSCC lesions and correlated to the intra-tumoral immune cell response, IFN-γ signaling and to the patient’s outcome. A heterogeneous but predominantly lower constitutive protein expression of HLA-I APM components was found in OSCC sections when compared to non-neoplastic cells. Tumoral HLA-I APM component expression was further categorized into the three major phenotypes HLA-Ihigh/APMhigh, HLA-Ilow/APMlow and HLA-Idiscordant high/low/APMhigh. In the HLA-Ihigh/APMhigh group, the highest frequency of intra-tumoral CD8+ T cells and lowest number of CD8+ T cells close to FoxP3+ cells were found. Patients within this group presented the most unfavorable survival, which was significantly evident in stage T2 tumors. Despite a correlation with the number of intra-tumoral CD8+ T cells, tumoral JAK1 expression as a surrogate marker for IFN-γ signaling was not associated with HLA-I/APM expression. Thus, the presented findings strongly indicate the presence of additional factors involved in the immunomodulatory process of HPV-negative OSCC with a possible tumor-burden-dependent complex network of immune escape mechanisms beyond HLA-I/APM components and T cell infiltration in this tumor entity.

Sign in / Sign up

Export Citation Format

Share Document