Efficient tumor cell lysis mediated by a Bcl-X(L) specific T cell clone isolated from a breast cancer patient

2006 ◽  
Vol 56 (4) ◽  
pp. 527-533 ◽  
Author(s):  
Rikke Bæk Sørensen ◽  
Sine Reker Hadrup ◽  
Tania Køllgaard ◽  
Inge Marie Svane ◽  
Per thor Straten ◽  
...  
Keyword(s):  
Breast Cancer ◽  
T Cell ◽  
Cancer Patient ◽  
Tumor Cell ◽  
Breast Cancer Patient ◽  
Cell Clone ◽  
Cell Lysis ◽  
T Cell Clone ◽  
Tumor Cell Lysis

scholarly journals A survivin specific T-cell clone from a breast cancer patient displays universal tumor cell lysis

2008 ◽  
Vol 7 (12) ◽  
pp. 1885-1887 ◽  
Author(s):  
Rikke Bæk Sørensen ◽  
Inge Marie Svane ◽  
Per thor Straten ◽  
Mads Hald Andersen
Keyword(s):  
Breast Cancer ◽  
T Cell ◽  
Cancer Patient ◽  
Tumor Cell ◽  
Breast Cancer Patient ◽  
Cell Clone ◽  
Cell Lysis ◽  
T Cell Clone ◽  
Tumor Cell Lysis

scholarly journals Interplay of tRNA-Derived Fragments and T Cell Activation in Breast Cancer Patient Survival

Cancers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2230 ◽  
Author(s):  
Nayang Shan ◽  
Ningshan Li ◽  
Qile Dai ◽  
Lin Hou ◽  
Xiting Yan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Overall Survival ◽  
T Cell ◽  
Cancer Patient ◽  
Breast Cancer Patient ◽  
T Cell Activation ◽  
Cell Activation ◽  
Cox Regression ◽  
Patient Survival ◽  
Significant Difference

Effector CD8+ T cell activation and its cytotoxic function are positively correlated with improved survival in breast cancer. tRNA-derived fragments (tRFs) have recently been found to be involved in gene regulation in cancer progression. However, it is unclear how interactions between expression of tRFs and T cell activation affect breast cancer patient survival. We used Kaplan–Meier survival and multivariate Cox regression models to evaluate the effect of interactions between expression of tRFs and T cell activation on survival in 1081 breast cancer patients. Spearman correlation analysis and weighted gene co-expression network analysis were conducted to identify genes and pathways that were associated with tRFs. tRFdb-5024a, 5P_tRNA-Leu-CAA-4-1, and ts-49 were positively associated with overall survival, while ts-34 and ts-58 were negatively associated with overall survival. Significant interactions were detected between T cell activation and ts-34 and ts-49. In the T cell exhaustion group, patients with a low level of ts-34 or a high level of ts-49 showed improved survival. In contrast, there was no significant difference in the activation group. Breast cancer related pathways were identified for the five tRFs. In conclusion, the identified five tRFs associated with overall survival may serve as therapeutic targets and improve immunotherapy in breast cancer.

Establishment and characterization of a circulating tumor cell line from a breast cancer patient.

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. e13062-e13062
Author(s):  
Pan Zhao ◽  
Chang Zou ◽  
Hong Hu ◽  
Cai neng Zhong ◽  
Ya yuan Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patient ◽  
Tumor Cell ◽  
Breast Cancer Patient ◽  
Cell Line ◽  
Tumor Cell Line ◽  
Circulating Tumor Cell

Induction of tumor-cell lysis by bi-specific antibody recognizing ganglioside GD2 and T-cell antigen CD3

1993 ◽  
Vol 55 (3) ◽  
pp. 465-470 ◽  
Author(s):  
Helga Bernhard ◽  
Julia Karbach ◽  
Karl-Hermann Meyer Zum Büschenfelde ◽  
Wolfgang Strittmatter ◽  
Alexander Knuth
Keyword(s):  
T Cell ◽  
Tumor Cell ◽  
Specific Antibody ◽  
Cell Lysis ◽  
Ganglioside Gd2 ◽  
Cell Antigen ◽  
Tumor Cell Lysis

scholarly journals Chemotherapy and radiation therapy elicits tumor specific T cell responses in a breast cancer patient

BMC Cancer ◽  
2016 ◽  
Vol 16 (1) ◽  
Author(s):  
David Bernal-Estévez ◽  
Ramiro Sánchez ◽  
Rafael E. Tejada ◽  
Carlos Parra-López
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
T Cell ◽  
Cancer Patient ◽  
Breast Cancer Patient ◽  
T Cell Responses ◽  
Cell Responses

Dendritic Cells Pulsed with Tumor-Derived Lysate Augment T Cell Mediated Tumor Cell Lysis

2004 ◽  
Vol 131 (2) ◽  
pp. P176-P177 ◽  
Author(s):  
Silke Gronau ◽  
Michael Schmitt ◽  
Herbert Riechelmann
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Tumor Cell ◽  
Cell Lysis ◽  
Tumor Cell Lysis
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