Fat detection in granular-cell renal cell carcinoma using chemical-shift gradient-echo MR imaging: another renal tumor that contains fat

2000 ◽  
Vol 25 (1) ◽  
pp. 100-102 ◽  
Author(s):  
K. Yoshimitsu ◽  
H. Honda ◽  
T. Kuroiwa ◽  
H. Irie ◽  
T. Tajima ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Chemical Shift ◽  
Mr Imaging ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Renal Tumor ◽  
Granular Cell ◽  
Gradient Echo ◽  
Cell Renal Cell Carcinoma

Metastatic adrenal tumor from clear-cell renal cell carcinoma: a pitfall of chemical shift MR imaging

2001 ◽  
Vol 26 (4) ◽  
pp. 439-442 ◽  
Author(s):  
K. Shinozaki ◽  
K. Yoshimitsu ◽  
H. Honda ◽  
T. Kuroiwa ◽  
H. Irie ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Chemical Shift ◽  
Mr Imaging ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Adrenal Tumor ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma

Differentiation between papillary renal cell carcinoma and fat-poor angiomyolipoma: a preliminary study assessing detection of intratumoral hemorrhage with chemical shift MRI and T2*-weighted gradient echo

2017 ◽  
Vol 59 (5) ◽  
pp. 627-634 ◽  
Author(s):  
Sungmin Woo ◽  
Sang Youn Kim ◽  
Jeong Yeon Cho ◽  
Seung Hyup Kim
Keyword(s):  
Renal Cell Carcinoma ◽  
Chemical Shift ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Papillary Renal Cell Carcinoma ◽  
Observer Agreement ◽  
Gradient Echo ◽  
Intratumoral Hemorrhage ◽  
Chemical Shift Mri ◽  
Consensus Reading

Background Recent literature suggests that intratumoral hemorrhage detection may be helpful in differentiating papillary renal cell carcinoma (pRCC) from fat-poor angiomyolipoma (fpAML). Purpose To determine whether intratumoral hemorrhage detected using chemical shift magnetic resonance imaging (MRI) and T2*-weighted (T2*W) gradient echo (GRE) can be used to differentiate pRCC from fpAML. Material and Methods This retrospective study included 42 patients with pRCC (n = 28) and fpAML (n = 14) who underwent MRI followed by surgery. Two blinded radiologists independently assessed the presence of intratumoral hemorrhage using chemical shift MRI (decrease in signal intensity from opposed- to in-phase) and T2*W GRE (“blooming”). Consensus reading was determined for discrepant cases. MRI findings were compared using Chi-square test. Inter-observer agreement was assessed using kappa statistics. Results Inter-observer agreement was substantial for both sequences ( k = 0.622 and 0.793, P < 0.001). For chemical shift MRI, the prevalence of intratumoral hemorrhage was significantly greater in pRCC than in fpAML (71.4% versus 28.6%, P = 0.019 for reader 1; 64.3% versus 14.3%, P = 0.003 for reader 2; and 75% versus 21.4%, P = 0.002 for the consensus). T2*W GRE showed a similar tendency (46.4% versus 14.3%, P = 0.049 for both readers; and 50% versus 14.3%, P = 0.042 for the consensus). Using the consensus reading, sensitivity and specificity of determining pRCC were 75% and 78.6% for chemical shift MRI and 50% and 85.7% for T2*W GRE. Conclusion The prevalence of intratumoral hemorrhage identified from chemical shift MRI or T2*W GRE was significantly different between pRCC and fpAML. These hemorrhage-sensitive MRI sequences may be used as an adjunctive tool for discriminating between the two entities.

scholarly journals Differential Diagnosis of Renal Tumors With Clear Cytoplasm: Clinical Relevance of Renal Tumor Subclassification in the Era of Targeted Therapies and Personalized Medicine

2013 ◽  
Vol 137 (4) ◽  
pp. 467-480 ◽  
Author(s):  
Rajen Goyal ◽  
Elizabeth Gersbach ◽  
Ximing J. Yang ◽  
Stephen M. Rohan
Keyword(s):  
Renal Cell Carcinoma ◽  
Differential Diagnosis ◽  
Cell Carcinoma ◽  
Targeted Therapies ◽  
Renal Cell ◽  
Clear Cell ◽  
Renal Tumor ◽  
Renal Tumors ◽  
Cell Renal Cell Carcinoma ◽  
Immunohistochemical Stains

Context.—The World Health Organization classification of renal tumors synthesizes morphologic, immunohistochemical, and molecular findings to define more than 40 tumor types. Of these, clear cell (conventional) renal cell carcinoma is the most common malignant tumor in adults and—with the exception of some rare tumors—the most deadly. The diagnosis of clear cell renal cell carcinoma on morphologic grounds alone is generally straightforward, but challenging cases are not infrequent. A misdiagnosis of clear cell renal cell carcinoma has clinical consequences, particularly in the current era of targeted therapies. Objective.—To highlight morphologic mimics of clear cell renal cell carcinoma and provide strategies to help differentiate clear cell renal cell carcinoma from other renal tumors and lesions. The role of the pathologist in guiding treatment for renal malignancies will be emphasized to stress the importance of proper tumor classification in patient management. Data Sources.—Published literature and personal experience. Conclusions.—In challenging cases, submission of additional tissue is often an inexpensive and effective way to facilitate a correct diagnosis. If immunohistochemical stains are to be used, it is best to use a panel of markers, as no one marker is specific for a given renal tumor subtype. Selection of limited markers, based on a specific differential diagnosis, can be as useful as a large panel in reaching a definitive diagnosis. For renal tumors, both the presence and absence of immunoreactivity and the pattern of labeling (membranous, cytoplasmic, diffuse, focal) are important when interpreting the results of immunohistochemical stains.

scholarly journals Detection of Intratumoral Susceptibility Signals Using T2*-Weighted Gradient Echo MRI in Patients with Clear Cell Renal Cell Carcinoma

PLoS ONE ◽  
2013 ◽  
Vol 8 (11) ◽  
pp. e79597 ◽  
Author(s):  
Shengnan Yu ◽  
Jianguo Qiu ◽  
Jinggang Zhang ◽  
Liang Pan ◽  
Shijun Xing ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Gradient Echo ◽  
Cell Renal Cell Carcinoma
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