Detection of lymph-node metastases in patients with gastric carcinoma: comparison of three MR imaging pulse sequences

2000 ◽  
Vol 25 (1) ◽  
pp. 25-29 ◽  
Author(s):  
M. Kato ◽  
S. Saji ◽  
M. Kanematsu ◽  
D. Fukada ◽  
K. Miya ◽  
...  
Keyword(s):  
Lymph Node ◽  
Gastric Carcinoma ◽  
Mr Imaging ◽  
Lymph Node Metastases ◽  
Pulse Sequences ◽  
Node Metastases

The prognostic value of P53 in the nodal metastization of gastric cancer.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e14673-e14673
Author(s):  
Luisa Quaresma ◽  
Antonio CALDEIRA Fradique ◽  
Fernanda Cabrita ◽  
Alexandra Pupo ◽  
Guedes DA Silva ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Prognostic Factor ◽  
Gastric Carcinoma ◽  
Lymph Node Metastases ◽  
P53 Protein ◽  
Mutant P53 ◽  
P53 Expression ◽  
Major Interest ◽  
Node Metastases

e14673 Background: Lymph node Metastases play a major role as an independent prognostic factor in gastric cancer. Presence of distal lymph node metastases assumes a pejorative prognostic significance, and represents a problem in terms of therapeutic approach. For this reason it’s of major interest to find predictive markers of distal lymph node chain involvement. The P53 tumor suppressor gene, a product of the TP53 gene works normally as a brake on DNA replication, as suppressor of angiogenesis and triggering of apoptosis. The gene most frequently mutated in gastric cancer is the TP53, that is responsible for the production of P53 mutant protein, which forms inactive complex with the native protein, and manifest by the overexpression of p53 in immunocytochemistry. The overexpression of P53 gene has been considered a bad prognostic factor associated mainly with lymph node metastases. Methods: This study seeks to determine the relation between the expression of P53 and the presence of distal lymph node metastases as an indicator for an extended lymphadenectomy. A total of 50 patients undergoing surgery with D2 lymphadenectomy for gastric carcinoma with curative intent were enrolled in this work. Therefore it was evaluated in 1,786 lymph nodes the correlation between the P53 expression with tumor location, size, histological type, depth , number of nodes involved, number of distal lymph node metastases and the TNM stage. Results: In all parameters, mutant P53 protein related with indicators of poor prognosis. In particular has demonstrated a statistical significant correlation (p=0.019) with the presence of distal lymph node metastases. The main objective of this study which was finding a prognostic predictor of distal nodal metastases has been reached. Conclusions: Mutant P53 protein is a good prognostic indicator, for the presence of distal lymph node involvement in gastric carcinoma.

Comparison of lymph node metastases assessment With the use of USPIO-enhanced MR imaging at 1.5 T versus 3.0 T in a rabbit model

2009 ◽  
Vol 31 (1) ◽  
pp. 134-141 ◽  
Author(s):  
Seung Hong Choi ◽  
Keon Ha Kim ◽  
Woo Kyung Moon ◽  
Hyo-Cheol Kim ◽  
Joo Hee Cha ◽  
...  
Keyword(s):  
Lymph Node ◽  
Mr Imaging ◽  
Lymph Node Metastases ◽  
Rabbit Model ◽  
3.0 T ◽  
Node Metastases

Mediastinal lymph node metastases from bronchogenic carcinoma: detection with MR imaging and CT.

Radiology ◽  
1987 ◽  
Vol 162 (3) ◽  
pp. 651-656 ◽  
Author(s):  
P Y Poon ◽  
M J Bronskill ◽  
R M Henkelman ◽  
D F Rideout ◽  
H S Shulman ◽  
...  
Keyword(s):  
Lymph Node ◽  
Mr Imaging ◽  
Lymph Node Metastases ◽  
Bronchogenic Carcinoma ◽  
Mediastinal Lymph Node ◽  
Node Metastases ◽  
Mediastinal Lymph Node Metastases

Detection of lymph node metastases in head and neck cancer: A meta-analysis comparing US, USgFNAC, CT and MR imaging

2007 ◽  
Vol 64 (2) ◽  
pp. 266-272 ◽  
Author(s):  
R.B.J. de Bondt ◽  
P.J. Nelemans ◽  
P.A.M. Hofman ◽  
J.W. Casselman ◽  
B. Kremer ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Lymph Node ◽  
Mr Imaging ◽  
Head And Neck ◽  
Neck Cancer ◽  
Lymph Node Metastases ◽  
Meta Analysis ◽  
Node Metastases
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