Pancreatic cystic neoplasms: the role and sensitivity of needle aspiration and biopsy

1998 ◽  
Vol 23 (4) ◽  
pp. 387-393 ◽  
Author(s):  
S. K. Carlson ◽  
C. D. Johnson ◽  
K. R. Brandt ◽  
K. P. Batts ◽  
D. R. Salomao
Keyword(s):  
Needle Aspiration ◽  
Cystic Neoplasms ◽  
Pancreatic Cystic Neoplasms

The Outcome of Endoscopic Ultrasound-Guided Fine-Needle Aspiration in Patients with Pancreatic Cystic Neoplasms: A Systematic Review

2020 ◽  
pp. 1-6
Author(s):  
Viswanath YKS ◽  
Ahmed Mehanna ◽  
Viswanath YKS ◽  
Talvinder Gill ◽  
Anil Reddy ◽  
...  
Keyword(s):  
Systematic Review ◽  
Malignant Tumors ◽  
High Specificity ◽  
Needle Aspiration ◽  
Pancreatic Cysts ◽  
Cystic Neoplasms ◽  
Pancreatic Cystic Neoplasms ◽  
Low Sensitivity ◽  
The Uk

Introduction: Pancreatic cancer is the sixth most common cause of death from cancer in the UK. Cystic pancreatic neoplasms are being recognized more with the increase in the use of the CT scan. EUS has been increasingly used to asses and identify lesions in the pancreas, however, it can’t differentiate between benign and malignant tumors alone. The role of EUS guided FNA cytology (EUS FNAC) is still controversial in the management of pancreatic cysts where neoplastic process is questioned. Aim: This systematic review is aiming to explore the currently available evidence assessing the role of EUS guided FNA cytology (EUS FNAC) in the management of pancreatic cystic neoplasms. Methods: A total of five studies with 597 patient EUS FNAC episodes were included in this systematic review. Results: The sensitivity of the EUS FNAC in the papers was variable between 46.7% to 91.7% while the sensitivity of the test was 100% for all the papers except for 1 paper which was 82.1%. CEA level was assessed in 3 papers, however, the cut off level was different. Conclusion: The high specificity of EUS FNAC qualify it as a useful adjunct to ascertain or exclude malignancy in the pancreatic cystic lesions. EUS FNAC cannot be used alone as a method of screening, given low sensitivity. Measuring CEA in the cyst fluid can be a good aide to increase the sensitivity and an identifiable cut off level should be proposed. Well-conducted and powered studies are needed to further explore the role of EUS FNAC in patients with pancreatic cystic neoplastic lesions.

scholarly journals Evaluation of the 2015 AGA guidelines on pancreatic cystic neoplasms in a large surgically confirmed multicenter cohort

2017 ◽  
Vol 05 (03) ◽  
pp. E201-E208 ◽  
Author(s):  
Phillip Ge ◽  
V. Muthusamy ◽  
Srinivas Gaddam ◽  
Diana-Marie Jaiyeola ◽  
Stephen Kim ◽  
...  
Keyword(s):  
Surgical Resection ◽  
Predictive Value ◽  
Needle Aspiration ◽  
Surgical Pathology ◽  
Cystic Neoplasms ◽  
Digestive Diseases ◽  
Diagnostic Characteristics ◽  
Diagnosis Of Cancer ◽  
Pancreatic Cystic Neoplasms ◽  
Retrospective Multicenter Study

Absract Background and study aims The American Gastroenterological Association (AGA) recently published guidelines for the management of asymptomatic pancreatic cystic neoplasms (PCNs). We aimed to evaluate the diagnostic characteristics of the AGA guidelines in appropriately recommending surgery for malignant PCNs. Patients and methods A retrospective multicenter study was performed of patients who underwent endoscopic ultrasound (EUS) for evaluation of PCNs who ultimately underwent surgical resection from 2004 – 2014. Demographics, EUS characteristics, fine-needle aspiration (FNA) results, type of resection, and final pathologic diagnosis were recorded. Patients were categorized into 2 groups (surgery or surveillance) based on what the AGA guidelines would have recommended. Performance characteristics for the diagnosis of cancer or high-grade dysplasia (HGD) on surgical pathology were calculated. Results Three hundred patients underwent surgical resection for PCNs, of whom the AGA guidelines would have recommended surgery in 121 (40.3 %) and surveillance in 179 (59.7 %) patients. Among patients recommended for surgery, 45 (37.2 %) had cancer, whereas 76 (62.8 %) had no cancer/HGD. Among patients recommended for surveillance, 170 (95.0 %) had no cancer/HGD; however, 9 (5.0 %) patients had cancer that would have been missed. For the finding of cancer/HGD on surgical pathology, the AGA guidelines had 83.3 % sensitivity (95 % CI 70.7 – 92.1), 69.1 % specificity (95 % CI 62.9 – 74.8), 37.2 % positive predictive value (95 % CI 28.6 – 46.4), 95.0 % negative predictive value (95 % CI 90.7 – 97.7), and 71.7 % accuracy (95 % CI 67.4 – 74.6). Conclusions The 2015 AGA guidelines would have resulted in 60 % fewer patients being referred for surgical resection, and accurately recommended surveillance in 95 % of patients with asymptomatic PCNs. Future prospective studies are required to validate these guidelines.Meeting presentations: Presented in part at Digestive Diseases Week 2016

Fine Needle Aspiration Biopsy for Preoperative Workup of Pancreatic Cystic Neoplasms

2007 ◽  
Vol 51 (6) ◽  
pp. 925-933 ◽  
Author(s):  
Nicolas Roustan Delatour ◽  
Maria Luisa C. Policarpio-Nicolas ◽  
Hossein Yazdi ◽  
Shahidul Islam
Keyword(s):  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Biopsy ◽  
Needle Aspiration ◽  
Aspiration Biopsy ◽  
Cystic Neoplasms ◽  
Fine Needle ◽  
Preoperative Workup ◽  
Pancreatic Cystic Neoplasms ◽  
Needle Aspiration Biopsy

Endoscopic ultrasound guided fine needle aspiration for the diagnosis of pancreatic cystic neoplasms: A meta-analysis

Pancreatology ◽  
2013 ◽  
Vol 13 (1) ◽  
pp. 48-57 ◽  
Author(s):  
G.D. Thornton ◽  
M.J.W. McPhail ◽  
S. Nayagam ◽  
M.J. Hewitt ◽  
P. Vlavianos ◽  
...  
Keyword(s):  
Endoscopic Ultrasound ◽  
Fine Needle Aspiration ◽  
Meta Analysis ◽  
Needle Aspiration ◽  
Ultrasound Guided ◽  
Cystic Neoplasms ◽  
Fine Needle ◽  
Pancreatic Cystic Neoplasms

scholarly journals PTU-234 Endoscopic ultrasound guided fine needle aspiration for the diagnosis of pancreatic cystic neoplasms: a meta-analysis

Gut ◽  
2012 ◽  
Vol 61 (Suppl 2) ◽  
pp. A281.1-A281
Author(s):  
G D Thornton ◽  
M J McPhail ◽  
S Nayagam ◽  
M J Hewitt ◽  
P Vlavianos ◽  
...  
Keyword(s):  
Endoscopic Ultrasound ◽  
Fine Needle Aspiration ◽  
Meta Analysis ◽  
Needle Aspiration ◽  
Ultrasound Guided ◽  
Cystic Neoplasms ◽  
Fine Needle ◽  
Pancreatic Cystic Neoplasms
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