Intravoxel incoherent motion parameters in the evaluation of chronic hepatitis B virus-induced hepatic injury: fibrosis and capillarity changes

2020 ◽  
Vol 45 (8) ◽  
pp. 2345-2357 ◽  
Author(s):  
Mutlu Gulbay ◽  
Deniz Sozmen Ciliz ◽  
Aysel Kocagul Celikbas ◽  
Devrim Tuba Ocalan ◽  
Bige Sayin ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Hepatic Injury ◽  
Intravoxel Incoherent Motion ◽  
Chronic Hepatitis B Virus ◽  
B Virus ◽  
Motion Parameters

scholarly journals Clinical Feature of Intrahepatic B-Lymphocytes in Chronic Hepatitis B

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Ashraf Mohamadkhani ◽  
Elnaz Naderi ◽  
Masoud Sotoudeh ◽  
Aezam Katoonizadeh ◽  
Ghodratollah Montazeri ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B Virus ◽  
B Cells ◽  
Hepatitis B ◽  
Liver Biopsy ◽  
B Lymphocytes ◽  
Chronic Hepatitis B ◽  
Hepatic Injury ◽  
Chronic Hepatitis B Virus ◽  
B Virus

Humoral immunity constitutes major defense mechanism against viral infections. However, the association of hepatic injury and B-cells population in chronic hepatitis B virus (HBV) carriers has not been studied well. In this study, fifty seven hepatitis B surface antigen (HBsAg) positive and HBeAg negative patients were studied to determine the expression of CD20, a cell surface marker expressed on B-cells, in liver biopsy sections using immunohistochemistry. The patients’ clinical data at the time of liver biopsy were acquired from their medical records. There was a significant association between log HBV DNA and both ALT (r=0.36,P=0.006) and histologic activity index (HAI) total score (r=0.3,P=0.02), respectively. The CD20 was expressed in all 57 liver biopsy samples with a submembranous and membranous staining pattern and its expression was significantly associated with HAI total score (r=0.32,P=0.01) and stage of fibrosis (r=0.31,P=0.02). The susceptible B lymphocytes to hepatitis B virus might be implicated in the development of immune mediated inflammation of HBV-induced hepatic injury. The present data also support that the liver is potentially one of the secondary lymphoid organs.

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