Scintigraphic evaluation of myocardial ischaemia using a new fatty acid analogue: iodine-123-labelled 15-( p -iodophenyl)-9-( R , S )-methylpentadecanoic acid (9MPA)

1999 ◽  
Vol 26 (8) ◽  
pp. 887-893 ◽  
Author(s):  
Jun Hashimoto ◽  
Atsushi Kubo ◽  
Ryuichiro Iwasaki ◽  
Hirofumi Fujii ◽  
Etsuo Kunieda ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Myocardial Ischaemia ◽  
Acid Analogue ◽  
Fatty Acid Analogue ◽  
Iodine 123

Prognostic value of iodine-123 labelled BMIPP fatty acid analogue imaging in patients with myocardial infarction

1996 ◽  
Vol 23 (3) ◽  
pp. 272-279 ◽  
Author(s):  
Nagara Tamaki ◽  
Eiji Tadamura ◽  
Takashi Kudoh ◽  
Naoya Hattori ◽  
Yoshiharu Yonekura ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Fatty Acid ◽  
Prognostic Value ◽  
Acid Analogue ◽  
Fatty Acid Analogue ◽  
Iodine 123

scholarly journals Fatty acid analogue N-arachidonoyl taurine restores function of IKs channels with diverse long QT mutations

eLife ◽  
2016 ◽  
Vol 5 ◽  
Author(s):  
Sara I Liin ◽  
Johan E Larsson ◽  
Rene Barro-Soria ◽  
Bo Hjorth Bentzen ◽  
H Peter Larsson
Keyword(s):  
Fatty Acid ◽  
Long Qt Syndrome ◽  
Molecular Mechanisms ◽  
Loss Of Function ◽  
Long Qt ◽  
Acid Analogue ◽  
Fatty Acid Analogue ◽  
Qt Syndrome ◽  
Channel Currents ◽  
Iks Channel

About 300 loss-of-function mutations in the IKs channel have been identified in patients with Long QT syndrome and cardiac arrhythmia. How specific mutations cause arrhythmia is largely unknown and there are no approved IKs channel activators for treatment of these arrhythmias. We find that several Long QT syndrome-associated IKs channel mutations shift channel voltage dependence and accelerate channel closing. Voltage-clamp fluorometry experiments and kinetic modeling suggest that similar mutation-induced alterations in IKs channel currents may be caused by different molecular mechanisms. Finally, we find that the fatty acid analogue N-arachidonoyl taurine restores channel gating of many different mutant channels, even though the mutations are in different domains of the IKs channel and affect the channel by different molecular mechanisms. N-arachidonoyl taurine is therefore an interesting prototype compound that may inspire development of future IKs channel activators to treat Long QT syndrome caused by diverse IKs channel mutations.

scholarly journals Molecular modelling, synthesis, and biological evaluations of a 3,5-disubstituted isoxazole fatty acid analogue as a PPARα-selective agonist

2019 ◽  
Vol 27 (18) ◽  
pp. 4059-4068 ◽  
Author(s):  
Henriette Arnesen ◽  
Nadia Nabil Haj-Yasein ◽  
Jørn E. Tungen ◽  
Helen Soedling ◽  
Jason Matthews ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Molecular Modelling ◽  
Selective Agonist ◽  
Acid Analogue ◽  
Fatty Acid Analogue

scholarly journals Fatty acid analogue accumulation: a marker of myocyte viability in ischemic-reperfused myocardium.

1988 ◽  
Vol 63 (4) ◽  
pp. 681-692 ◽  
Author(s):  
D D Miller ◽  
J B Gill ◽  
E Livni ◽  
D R Elmaleh ◽  
T Aretz ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Acid Analogue ◽  
Fatty Acid Analogue ◽  
Reperfused Myocardium

scholarly journals Significance of reduced uptake of iodinated fatty acid analogue for the evaluation of patients with acute chest pain

2001 ◽  
Vol 38 (7) ◽  
pp. 1888-1894 ◽  
Author(s):  
Yuko Kawai ◽  
Eriko Tsukamoto ◽  
Yoichi Nozaki ◽  
Koichi Morita ◽  
Masayuki Sakurai ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Chest Pain ◽  
Acute Chest Pain ◽  
Acid Analogue ◽  
Fatty Acid Analogue
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